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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23447

FusionGeneSummary for NAT10_METTL15

check button Fusion gene summary
Fusion gene informationFusion gene name: NAT10_METTL15
Fusion gene ID: 23447
HgeneTgene
Gene symbol

NAT10

METTL15

Gene ID

55226

196074

Gene nameN-acetyltransferase 10methyltransferase like 15
SynonymsALP|Kre33|NET43METT5D1
Cytomap

11p13

11p14.1

Type of geneprotein-codingprotein-coding
DescriptionRNA cytidine acetyltransferase18S rRNA cytosine acetyltransferaseN-acetyltransferase 10 (GCN5-related)N-acetyltransferase-like proteinprobable methyltransferase-like protein 15methyltransferase 5 domain containing 1methyltransferase 5 domain-containing protein 1probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1putative S-adenosyl-L-methionine-dependent methyltransf
Modification date2018052320180523
UniProtAcc

Q9H0A0

A6NJ78

Ensembl transtripts involved in fusion geneENST00000257829, ENST00000531159, 
ENST00000527971, ENST00000532555, 
ENST00000406787, ENST00000342303, 
ENST00000407364, ENST00000303459, 
ENST00000403099, ENST00000379199, 
Fusion gene scores* DoF score2 X 3 X 3=183 X 3 X 3=27
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NAT10 [Title/Abstract] AND METTL15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-SI-A71Q-01ANAT10chr11

34145402

+METTL15chr11

28420335

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257829ENST00000406787NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000257829ENST00000342303NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000257829ENST00000407364NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000257829ENST00000303459NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000257829ENST00000403099NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000257829ENST00000379199NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000531159ENST00000406787NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000531159ENST00000342303NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000531159ENST00000407364NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000531159ENST00000303459NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000531159ENST00000403099NAT10chr11

34145402

+METTL15chr11

28420335

+
5CDS-intronENST00000531159ENST00000379199NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000527971ENST00000406787NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000527971ENST00000342303NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000527971ENST00000407364NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000527971ENST00000303459NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000527971ENST00000403099NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000527971ENST00000379199NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000532555ENST00000406787NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000532555ENST00000342303NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000532555ENST00000407364NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000532555ENST00000303459NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000532555ENST00000403099NAT10chr11

34145402

+METTL15chr11

28420335

+
intron-intronENST00000532555ENST00000379199NAT10chr11

34145402

+METTL15chr11

28420335

+

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FusionProtFeatures for NAT10_METTL15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAT10

Q9H0A0

METTL15

A6NJ78

RNA cytidine acetyltransferase with specificity towardboth 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167).Catalyzes the formation of N(4)-acetylcytidine (ac4C) at position1842 in 18S rRNA (PubMed:25411247). May also catalyze theformation of ac4C at position 1337 in 18S rRNA (By similarity).Required for early nucleolar cleavages of precursor rRNA at sitesA0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247,PubMed:25653167). Catalyzes the formation of ac4C in serine andleucine tRNAs (By similarity). Requires the tRNA-binding adapterprotein THUMBD1 for full tRNA acetyltransferase activity but notfor 18S rRNA acetylation (PubMed:25653167). Can acetylate bothhistones and microtubules (PubMed:14592445, PubMed:17631499,PubMed:19303003). Histone acetylation may regulate transcriptionand mitotic chromosome de-condensation (PubMed:17631499).Activates telomerase activity by stimulating the transcription ofTERT, and may also regulate telomerase function by affecting thebalance of telomerase subunit assembly, disassembly, andlocalization (PubMed:14592445, PubMed:18082603). Acetylates alpha-tubulin, which may affect microtubule stability and cell division(PubMed:19303003). {ECO:0000250|UniProtKB:P53914,ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000269|PubMed:14592445,ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603,ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247,ECO:0000269|PubMed:25653167}. Probable S-adenosyl-L-methionine-dependentmethyltransferase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAT10_METTL15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAT10_METTL15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAT10LYAR, OTUB1, TERT, TOP1, SIRT1, SIRT7, CUL3, CUL1, CAND1, GRK5, UTP20, DGCR8, DHX37, ESR1, FN1, ITGA4, BRCA1, CUL7, OBSL1, UBE2I, SUZ12, EED, RNF2, BMI1, ABCE1, FBXW11, NOL12, RPS2, RPS8, THUMPD1, NTRK1, ABCF2, EIF4G1, DDX18, IMP4, NOP58, RPS5, SRPK1, SSB, NOP2, RPL5, TSR1, IFI16, HNRNPU, NPM1, RPL10, VIM, TFG, SYNCRIP, NOP56, IBTK, MCM5, CDC5L, TP53, MDM2, UBE2D2, UBC, C1orf131, CDC14B, NOL10, HIST1H1T, RPS14, ZNF512, MECP2, RPL18A, ZNF169, GPATCH4, FGF8, RRP8, RPS11, LASP1, TRIM25, MTF1METTL15CUL3, TRIP13, MVB12B, BSG, LIPT1, UBR2, KLHL22, RBFA, EMILIN1, CD70, IL13RA2, LAMP3, KBTBD7, GYPB, CD79A, SLC2A12, MAS1, SLC15A1, KIR3DL2, APLNR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAT10_METTL15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAT10_METTL15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource