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Fusion gene ID: 23446 |
FusionGeneSummary for NAT10_CAPRIN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NAT10_CAPRIN1 | Fusion gene ID: 23446 | Hgene | Tgene | Gene symbol | NAT10 | CAPRIN1 | Gene ID | 55226 | 4076 |
| Gene name | N-acetyltransferase 10 | cell cycle associated protein 1 | |
| Synonyms | ALP|Kre33|NET43 | GPIAP1|GPIP137|GRIP137|M11S1|RNG105|p137GPI | |
| Cytomap | 11p13 | 11p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA cytidine acetyltransferase18S rRNA cytosine acetyltransferaseN-acetyltransferase 10 (GCN5-related)N-acetyltransferase-like protein | caprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation- | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H0A0 | Q14444 | |
| Ensembl transtripts involved in fusion gene | ENST00000257829, ENST00000531159, ENST00000527971, ENST00000532555, | ENST00000341394, ENST00000389645, ENST00000532820, ENST00000530820, ENST00000529307, ENST00000533657, | |
| Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 6 X 5 X 4=120 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NAT10 [Title/Abstract] AND CAPRIN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AN-A0XU-01A | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| TCGA | RV | OV | TCGA-13-1501-01A | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000257829 | ENST00000341394 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000257829 | ENST00000389645 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000257829 | ENST00000532820 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000257829 | ENST00000530820 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000257829 | ENST00000529307 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5CDS-3UTR | ENST00000257829 | ENST00000533657 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000531159 | ENST00000341394 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000531159 | ENST00000389645 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000531159 | ENST00000532820 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000531159 | ENST00000530820 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000531159 | ENST00000529307 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3UTR | ENST00000531159 | ENST00000533657 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000527971 | ENST00000341394 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000527971 | ENST00000389645 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000527971 | ENST00000532820 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000527971 | ENST00000530820 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| Frame-shift | ENST00000527971 | ENST00000529307 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5CDS-3UTR | ENST00000527971 | ENST00000533657 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000341394 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000389645 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000532820 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000530820 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000529307 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3UTR | ENST00000532555 | ENST00000533657 | NAT10 | chr11 | 34130380 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000257829 | ENST00000341394 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000257829 | ENST00000389645 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000257829 | ENST00000532820 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000257829 | ENST00000530820 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000257829 | ENST00000529307 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3UTR | ENST00000257829 | ENST00000533657 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000531159 | ENST00000341394 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000531159 | ENST00000389645 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000531159 | ENST00000532820 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000531159 | ENST00000530820 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3CDS | ENST00000531159 | ENST00000529307 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| 5UTR-3UTR | ENST00000531159 | ENST00000533657 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000527971 | ENST00000341394 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000527971 | ENST00000389645 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000527971 | ENST00000532820 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000527971 | ENST00000530820 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000527971 | ENST00000529307 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3UTR | ENST00000527971 | ENST00000533657 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000341394 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000389645 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000532820 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000530820 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3CDS | ENST00000532555 | ENST00000529307 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
| intron-3UTR | ENST00000532555 | ENST00000533657 | NAT10 | chr11 | 34127339 | + | CAPRIN1 | chr11 | 34118026 | + |
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FusionProtFeatures for NAT10_CAPRIN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NAT10 | CAPRIN1 |
| RNA cytidine acetyltransferase with specificity towardboth 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167).Catalyzes the formation of N(4)-acetylcytidine (ac4C) at position1842 in 18S rRNA (PubMed:25411247). May also catalyze theformation of ac4C at position 1337 in 18S rRNA (By similarity).Required for early nucleolar cleavages of precursor rRNA at sitesA0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247,PubMed:25653167). Catalyzes the formation of ac4C in serine andleucine tRNAs (By similarity). Requires the tRNA-binding adapterprotein THUMBD1 for full tRNA acetyltransferase activity but notfor 18S rRNA acetylation (PubMed:25653167). Can acetylate bothhistones and microtubules (PubMed:14592445, PubMed:17631499,PubMed:19303003). Histone acetylation may regulate transcriptionand mitotic chromosome de-condensation (PubMed:17631499).Activates telomerase activity by stimulating the transcription ofTERT, and may also regulate telomerase function by affecting thebalance of telomerase subunit assembly, disassembly, andlocalization (PubMed:14592445, PubMed:18082603). Acetylates alpha-tubulin, which may affect microtubule stability and cell division(PubMed:19303003). {ECO:0000250|UniProtKB:P53914,ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000269|PubMed:14592445,ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603,ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247,ECO:0000269|PubMed:25653167}. | May regulate the transport and translation of mRNAs ofproteins involved in synaptic plasticity in neurons and cellproliferation and migration in multiple cell types. Binds directlyand selectively to MYC and CCND2 RNAs. In neuronal cells, directlybinds to several mRNAs associated with RNA granules, includingBDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 andKPNB1 mRNAs, but not to rRNAs. {ECO:0000269|PubMed:17210633}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NAT10_CAPRIN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NAT10_CAPRIN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NAT10 | LYAR, OTUB1, TERT, TOP1, SIRT1, SIRT7, CUL3, CUL1, CAND1, GRK5, UTP20, DGCR8, DHX37, ESR1, FN1, ITGA4, BRCA1, CUL7, OBSL1, UBE2I, SUZ12, EED, RNF2, BMI1, ABCE1, FBXW11, NOL12, RPS2, RPS8, THUMPD1, NTRK1, ABCF2, EIF4G1, DDX18, IMP4, NOP58, RPS5, SRPK1, SSB, NOP2, RPL5, TSR1, IFI16, HNRNPU, NPM1, RPL10, VIM, TFG, SYNCRIP, NOP56, IBTK, MCM5, CDC5L, TP53, MDM2, UBE2D2, UBC, C1orf131, CDC14B, NOL10, HIST1H1T, RPS14, ZNF512, MECP2, RPL18A, ZNF169, GPATCH4, FGF8, RRP8, RPS11, LASP1, TRIM25, MTF1 | CAPRIN1 | PINX1, PRMT1, G3BP1, GIGYF2, SIRT7, TSG101, CUL3, CUL1, COPS5, CAND1, APP, CIRBP, ESR1, IGSF8, FBXO6, TARDBP, WBP4, PIN1, RPA3, RPA2, RPA1, FXR1, FXR2, STAU1, RNF2, BMI1, SIRT6, CDK2, ILK, RPS6KB2, HNRNPA1, NTRK1, RPL7, YBX1, NF2, EGFR, CYLD, DNM1L, BRCA1, RPS6, G3BP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NAT10_CAPRIN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NAT10_CAPRIN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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