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Fusion gene ID: 23436 |
FusionGeneSummary for NARS2_TOP1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NARS2_TOP1 | Fusion gene ID: 23436 | Hgene | Tgene | Gene symbol | NARS2 | TOP1 | Gene ID | 79731 | 7150 |
Gene name | asparaginyl-tRNA synthetase 2, mitochondrial | DNA topoisomerase I | |
Synonyms | DFNB94|SLM5|asnRS | TOPI | |
Cytomap | 11q14.1 | 20q12 | |
Type of gene | protein-coding | protein-coding | |
Description | probable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrial | DNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerase | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96I59 | P11387 | |
Ensembl transtripts involved in fusion gene | ENST00000281038, ENST00000528850, | ENST00000361337, | |
Fusion gene scores | * DoF score | 12 X 8 X 5=480 | 6 X 5 X 3=90 |
# samples | 13 | 6 | |
** MAII score | log2(13/480*10)=-1.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NARS2 [Title/Abstract] AND TOP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TOP1 | GO:0006265 | DNA topological change | 14594810 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-BH-A0HL-01A | NARS2 | chr11 | 78239888 | - | TOP1 | chr20 | 39721112 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000281038 | ENST00000361337 | NARS2 | chr11 | 78239888 | - | TOP1 | chr20 | 39721112 | + |
In-frame | ENST00000528850 | ENST00000361337 | NARS2 | chr11 | 78239888 | - | TOP1 | chr20 | 39721112 | + |
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FusionProtFeatures for NARS2_TOP1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NARS2 | TOP1 |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | TOP1 | chr11:78239888 | chr20:39721112 | ENST00000361337 | + | 7 | 21 | 23_204 | 204 | 766 | Compositional bias | Note=Lys-rich |
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FusionGeneSequence for NARS2_TOP1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_NARS2_ENST00000281038_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_791aa MLGVRCLLRSVRFCSSAPFPKHKPSAKLSVRDALGAQNASGERIKIQGWIRSVRSQKEVLFLHVNDGSSLESLQVVADSGLDSRELNFGS SVEVQGQLIKSPSKRQNVELKAEKIKVIGNCDAKDFPIKYKERHPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHT PIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAFLTVSGQLHLEVMSGWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGK VMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLL KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIK YIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLH PELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKEL TAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLE >In-frame_NARS2_ENST00000528850_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_564aa MSGWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKN IITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDI IINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKV RQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPED DLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKID AKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEK |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_NARS2_ENST00000281038_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_2373nt ATGCTGGGGGTCCGCTGCCTGCTGCGGTCCGTGCGCTTCTGTTCCTCCGCCCCCTTCCCCAAGCACAAACCTTCAGCCAAACTGAGCGTG CGGGACGCTCTCGGGGCTCAGAACGCGAGTGGGGAGCGCATTAAGATCCAGGGATGGATTCGTTCTGTCCGATCCCAGAAGGAAGTCTTG TTCCTGCATGTAAATGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGAATTAAATTTTGGGAGT TCTGTGGAAGTACAAGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAATTAAAGTTATTGGAAAT TGTGATGCCAAGGATTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTTTAGGTGTAGGACTAAC GTTCTGGGTTCTATATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTTTGTACATATTCATACT CCAATAATCACATCCAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGTACCTGAGGAGAATTTC TTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGGTGGGAAGAAGAGCGCTATCCTGAAGGCATC AAGTGGAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAA GTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTACCAAGGAAATATTTAGG AAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATG AGCCAGTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTG AAAGAATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGC AACCACCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCT CCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAA TACATCATGCTTAACCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAGAAATACGAGACTGCTCGGCGGCTGAAAAAATGTGTGGAC AAGATCCGGAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCCCTGTACTTCATCGACAAGCTT GCTCTGAGAGCAGGCAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTGGGCTGCTGCTCACTTCGTGTGGAGCACATCAATCTACAC CCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAGGACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAA CGAGTTTTTAAGAACCTACAACTATTTATGGAGAACAAGCAGCCCGAGGATGATCTTTTTGATAGACTCAATACTGGTATTCTGAATAAG CATCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGCTACAGCAGCAGCTAAAAGAACTG ACAGCCCCGGATGAGAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCCAATCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCA CCACCAAAAACTTTTGAGAAGTCTATGATGAACTTGCAAACTAAGATTGATGCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTG AAAAGTGCTAAGGCTGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAGGTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAG GAACAGTTGATGAAGCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAACAGATTGCCCTGGGAACCTCCAAACTCAATTATCTGGAC CCTAGGATCACAGTGGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAGATTTACAACAAAACCCAGCGGGAGAAGTTTGCCTGGGCC >In-frame_NARS2_ENST00000528850_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_1692nt ATGTCAGGGTGGGAAGAAGAGCGCTATCCTGAAGGCATCAAGTGGAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAG CCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAA ATGCTCGACCATGAATATACTACCAAGGAAATATTTAGGAAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAAT ATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATGAGCCAGTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAA GAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTGAAAGAATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAAC TTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGCAACCACCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATA ATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGG CTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAATACATCATGCTTAACCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAG AAATACGAGACTGCTCGGCGGCTGAAAAAATGTGTGGACAAGATCCGGAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTC CGGCAGAGAGCTGTAGCCCTGTACTTCATCGACAAGCTTGCTCTGAGAGCAGGCAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTG GGCTGCTGCTCACTTCGTGTGGAGCACATCAATCTACACCCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAG GACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAACGAGTTTTTAAGAACCTACAACTATTTATGGAGAACAAGCAGCCCGAGGAT GATCTTTTTGATAGACTCAATACTGGTATTCTGAATAAGCATCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTATTCCGTACATAC AATGCCTCCATCACGCTACAGCAGCAGCTAAAAGAACTGACAGCCCCGGATGAGAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCC AATCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTTTTGAGAAGTCTATGATGAACTTGCAAACTAAGATTGAT GCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTGAAAAGTGCTAAGGCTGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAG GTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAGGAACAGTTGATGAAGCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAA CAGATTGCCCTGGGAACCTCCAAACTCAATTATCTGGACCCTAGGATCACAGTGGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_NARS2_ENST00000281038_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_3939nt GTAGCGTGATGACGTAAGCGGCGTTGGCGTGGTGTGGTAGGAGTGGTTGCGCGTGTTGCGGCCCGGGTTCTGTTCGTAGGTTTACAATTG TCGCGGGTAGTGGGGCGCCCCAGCTGCCAACTGCACGTGGTTTCTTTCTGGCGTTTGCCTAGTGTCCTGTCCATTCCGCCCCGTTGGGAA GTGGGAAGCGGAGAGGTTCTGTGGGGACAGAGCTGGGAGTCCTGAAGGAGAAAGCGCGCAGCCGAGGGGCTCTGGAGTGCCTTAGAGCAG AGCTGCGGCCGCGGAAGGGGAGCAGCTGAGAAAGGAGGGCCGCTGCAGGCGGGGTTCGAACCGTGGGGTCTGGGCTGCTCCCGCGGAGGG CCTGGGCGGACGCGGGATGCTGGGGGTCCGCTGCCTGCTGCGGTCCGTGCGCTTCTGTTCCTCCGCCCCCTTCCCCAAGCACAAACCTTC AGCCAAACTGAGCGTGCGGGACGCTCTCGGGGCTCAGAACGCGAGTGGGGAGCGCATTAAGATCCAGGGATGGATTCGTTCTGTCCGATC CCAGAAGGAAGTCTTGTTCCTGCATGTAAATGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGA ATTAAATTTTGGGAGTTCTGTGGAAGTACAAGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAAT TAAAGTTATTGGAAATTGTGATGCCAAGGATTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTT TAGGTGTAGGACTAACGTTCTGGGTTCTATATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTT TGTACATATTCATACTCCAATAATCACATCCAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGT ACCTGAGGAGAATTTCTTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGGTGGGAAGAAGAGCG CTATCCTGAAGGCATCAAGTGGAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTT TTATTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTAC CAAGGAAATATTTAGGAAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATG TGATTTTACCCAGATGAGCCAGTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGA GAATGAAAAATTACTGAAAGAATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACT TTTCCGTGGCCGCGGCAACCACCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGC CAAGGTTCCTTCTCCTCCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACAT CCAAGGTTCCATTAAATACATCATGCTTAACCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAGAAATACGAGACTGCTCGGCGGCT GAAAAAATGTGTGGACAAGATCCGGAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCCCTGTA CTTCATCGACAAGCTTGCTCTGAGAGCAGGCAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTGGGCTGCTGCTCACTTCGTGTGGA GCACATCAATCTACACCCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAGGACTCCATCAGATACTATAACAA GGTCCCTGTTGAGAAACGAGTTTTTAAGAACCTACAACTATTTATGGAGAACAAGCAGCCCGAGGATGATCTTTTTGATAGACTCAATAC TGGTATTCTGAATAAGCATCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGCTACAGCA GCAGCTAAAAGAACTGACAGCCCCGGATGAGAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCCAATCGAGCTGTTGCAATTCTTTG TAACCATCAGAGGGCACCACCAAAAACTTTTGAGAAGTCTATGATGAACTTGCAAACTAAGATTGATGCCAAGAAGGAACAGCTAGCAGA TGCCCGGAGAGACCTGAAAAGTGCTAAGGCTGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAGGTAGTAGAGTCAAAGAAGAAGGC TGTTCAGAGACTGGAGGAACAGTTGATGAAGCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAACAGATTGCCCTGGGAACCTCCAA ACTCAATTATCTGGACCCTAGGATCACAGTGGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAGATTTACAACAAAACCCAGCGGGA GAAGTTTGCCTGGGCCATTGACATGGCTGATGAAGACTATGAGTTTTAGCCAGTCTCAAGAGGCAGAGTTCTGTGAAGAGGAACAGTGTG GTTTGGGAAAGATGGATAAACTGAGCCTCACTTGCCCTCGTGCCTGGGGGAGAGAGGCAGCAAGTCTTAACAAACCAACATCTTTGCGAA AAGATAAACCTGGAGATATTATAAGGGAGAGCTGAGCCAGTTGTCCTATGGACAACTTATTTAAAAATATTTCAGATATCAAAATTCTAG CTGTATGATTTGTTTTGAATTTTGTTTTTATTTTCAAGAGGGCAAGTGGATGGGAATTTGTCAGCGTTCTACCAGGCAAATTCACTGTTT CACTGAAATGTTTGGATTCTCTTAGCTACTGTATGCAAAGTCCGATTATATTGGTGCGTTTTTACAGTTAGGGTTTTGCAATAACTTCTA TATTTTAATAGAAATAAATTCCTAAACTCCCTTCCCTCTCTCCCATTTCAGGAATTTAAAATTAAGTAGAACAAAAAACCCAGCGCACCT GTTAGAGTCGTCACTCTCTATTGTCATGGGGATCAATTTTCATTAAACTTGAAGCAGTCGTGGCTTTGGCAGTGTTTTGGTTCAGACACC TGTTCACAGAAAAAGCATGATGGGAAAATATTTCCTGACTTGAGTGTTCCTTTTTAAATGTGAATTTTTATTTCTTTTTAATTATTTTAA AATATTTAAACCTTTTTCTTGATCTTAAAGATCGTGTAGATTGGGGTTGGGGAGGGATGAAGGGCGAGTGAATCTAAGGATAATGAAATA ATCAGTGACTGAAACCATTTTCCCATCATCCTTTGTTCTGAGCATTCGCTGTACCCTTTAAGATATCCATCTTTTTCTTTTTAACCCTAA TCTTTCACTTGAAAGATTTTATTGTATAAAAAGTTTCACAGGTCAATAAACTTAGAGGAAAATGAGTATTTGGTCCAAAAAAAGGAAAAA TAATCAAGATTTTAGGGCTTTTATTTTTTCTTTTGTAATTGTGTAAAAAATGGAAAAAAACATAAAAAGCAGAATTTTAATGTGAAGACA TTTTTTGCTATAATCATTAGTTTTAGAGGCATTGTTAGTTTAGTGTGTGTGCAGAGTCCATTTCCCACATCTTTCCTCAAGTATCTTCTA >In-frame_NARS2_ENST00000528850_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_3819nt AGGGTCTAGCTCTGTCACCCAGACTGGAGCGCAGTGATGTGATCTCAGATGACTACAACCTCCATCTCCCAGGCTCAAGCAATCCTCCTG CCTCGGCCTCCAGAGTAGCTGAAACTATAGGCATGCACCACCACACTCTATAATTTTTTAAGTTTTTTGTGAAGATGAGTCTCACTGTAT TGCCCAGGCTGGTCTCAAACTCCTGGACTCAAGCAGTCCTCCTCCTTCGGCATCCCAAAATGCTGGGATTACAGGCATAAGCCTGGTAGA TGTTGTTATAATAAATACTTATTTTTTGAGTAGGTTCTTGCTTTGTCACCCATGATTGTACTGACACAGTCATGGCTTGCCGTTGCAGTG ATTTCTGTTGTCCTCACATATCCTTTACTTTTTAGCGGGATGGATTCGTTCTGTCCGATCCCAGAAGGAAGTCTTGTTCCTGCATGTAAA TGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGAATTAAATTTTGGGAGTTCTGTGGAAGTACA AGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAATTAAAGTTATTGGAAATTGTGATGCCAAGGA TTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTTTAGGTGTAGGACTAACGTTCTGGGTTCTAT ATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTTTGTACATATTCATACTCCAATAATCACATC CAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGTACCTGAGGAGAATTTCTTCAATGTTCCTGC TTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGGTGGGAAGAAGAGCGCTATCCTGAAGGCATCAAGTGGAAATTCCT AGAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAAGTCATGAAGCTGAG CCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTACCAAGGAAATATTTAGGAAAAATTTCTTTAA AGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATGAGCCAGTATTTCAA AGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTGAAAGAATATGGATT CTGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGCAACCACCCCAAGAT GGGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCCAGGACATAA GTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAATACATCATGCTTAA CCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAGAAATACGAGACTGCTCGGCGGCTGAAAAAATGTGTGGACAAGATCCGGAACCA GTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCCCTGTACTTCATCGACAAGCTTGCTCTGAGAGCAGG CAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTGGGCTGCTGCTCACTTCGTGTGGAGCACATCAATCTACACCCAGAGTTGGATGG TCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAGGACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAACGAGTTTTTAAGAA CCTACAACTATTTATGGAGAACAAGCAGCCCGAGGATGATCTTTTTGATAGACTCAATACTGGTATTCTGAATAAGCATCTTCAGGATCT CATGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGCTACAGCAGCAGCTAAAAGAACTGACAGCCCCGGATGA GAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCCAATCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTTT TGAGAAGTCTATGATGAACTTGCAAACTAAGATTGATGCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTGAAAAGTGCTAAGGC TGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAGGTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAGGAACAGTTGATGAA GCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAACAGATTGCCCTGGGAACCTCCAAACTCAATTATCTGGACCCTAGGATCACAGT GGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAGATTTACAACAAAACCCAGCGGGAGAAGTTTGCCTGGGCCATTGACATGGCTGA TGAAGACTATGAGTTTTAGCCAGTCTCAAGAGGCAGAGTTCTGTGAAGAGGAACAGTGTGGTTTGGGAAAGATGGATAAACTGAGCCTCA CTTGCCCTCGTGCCTGGGGGAGAGAGGCAGCAAGTCTTAACAAACCAACATCTTTGCGAAAAGATAAACCTGGAGATATTATAAGGGAGA GCTGAGCCAGTTGTCCTATGGACAACTTATTTAAAAATATTTCAGATATCAAAATTCTAGCTGTATGATTTGTTTTGAATTTTGTTTTTA TTTTCAAGAGGGCAAGTGGATGGGAATTTGTCAGCGTTCTACCAGGCAAATTCACTGTTTCACTGAAATGTTTGGATTCTCTTAGCTACT GTATGCAAAGTCCGATTATATTGGTGCGTTTTTACAGTTAGGGTTTTGCAATAACTTCTATATTTTAATAGAAATAAATTCCTAAACTCC CTTCCCTCTCTCCCATTTCAGGAATTTAAAATTAAGTAGAACAAAAAACCCAGCGCACCTGTTAGAGTCGTCACTCTCTATTGTCATGGG GATCAATTTTCATTAAACTTGAAGCAGTCGTGGCTTTGGCAGTGTTTTGGTTCAGACACCTGTTCACAGAAAAAGCATGATGGGAAAATA TTTCCTGACTTGAGTGTTCCTTTTTAAATGTGAATTTTTATTTCTTTTTAATTATTTTAAAATATTTAAACCTTTTTCTTGATCTTAAAG ATCGTGTAGATTGGGGTTGGGGAGGGATGAAGGGCGAGTGAATCTAAGGATAATGAAATAATCAGTGACTGAAACCATTTTCCCATCATC CTTTGTTCTGAGCATTCGCTGTACCCTTTAAGATATCCATCTTTTTCTTTTTAACCCTAATCTTTCACTTGAAAGATTTTATTGTATAAA AAGTTTCACAGGTCAATAAACTTAGAGGAAAATGAGTATTTGGTCCAAAAAAAGGAAAAATAATCAAGATTTTAGGGCTTTTATTTTTTC TTTTGTAATTGTGTAAAAAATGGAAAAAAACATAAAAAGCAGAATTTTAATGTGAAGACATTTTTTGCTATAATCATTAGTTTTAGAGGC ATTGTTAGTTTAGTGTGTGTGCAGAGTCCATTTCCCACATCTTTCCTCAAGTATCTTCTATTTTTATCATGAATTCCCTTTTAATCAACT |
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FusionGenePPI for NARS2_TOP1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NARS2 | SLC25A41, OXLD1, DARS2, ADRBK1, CHCHD2, RAB8B, PDK4, LAMP3, NDUFS7, HSPD1, ACSM5, TRNT1, CD70, YBEY, TMEM70, NIT1, GATC, CLEC2D, FOXRED1, OTC, BPNT1, CHRM3 | TOP1 | CSNK2A1, CSNK2A2, TP53, TAL1, NCL, SRSF1, BTBD1, BTBD2, TOPORS, SRSF11, SFPQ, UBE2I, CDT1, CDKN2A, RRP1B, H2AFY, PMS1, MGMT, HIST1H3E, H3F3A, MYC, ICT1, HDAC5, NOP56, NPM1, FBL, HIST1H1C, H1FX, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, HNRNPR, ELAVL1, MKI67, NAT10, DHX9, NOP2, NONO, PARP1, DDX21, DDX17, SF3B3, SF3B1, TCOF1, SNRPA1, DDX23, EFTUD2, SNRNP200, PRPF8, OAS3, EIF2AK2, PCNA, HDGF, SIRT7, GTF3C1, XRCC5, CUL3, CDK2, CUL1, COPS5, CAND1, DDB2, ERCC8, ATM, IRF4, BARD1, ELK3, TARBP2, KMT2A, IRF8, IRF9, SNW1, PRB1, SNRNP70, U2AF2, LSM4, GEMIN4, CDK8, BUB3, RBL1, RBL2, GRWD1, SYMPK, JAK1, LIG4, PPP2R2B, TRIM32, RCVRN, PYGM, APAF1, CKAP5, TUBD1, PDE10A, APP, HNRNPM, RPS14, SNRPD1, IK, RBM39, SF3B6, SUPT16H, UTP20, S100A9, NCSTN, RBM14, TPR, ESR1, NKX3-1, VCP, PA2G4, VCAM1, IL7R, ITGA4, HDAC9, CDK14, TARDBP, SHFM1, ERG, MDM2, CUL7, OBSL1, EED, RNF2, EAF1, ZRANB2, APLF, NTRK1, RBM25, PWP1, RBM28, TOP2A, TOP2B, SCARNA22, FSHR, SRPK2, LAMB3, TRIM26, NLRP3, MCM5, NF2, CDC5L, PES1, POU5F1, EGFR, FNTA, ARID1A, PDGFRA, ROR1, PBRM1, TSC1, ERBB2, MTOR, BRCA1, CDK4, ESAM, CIDEC, SNRPG, PRICKLE3, DUS4L, GTF2E2, NR3C1, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, PDHA1, VDAC1, TRIM25, LMNA |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | TOP1 | chr11:78239888 | chr20:39721112 | ENST00000361337 | + | 7 | 21 | 425_426 | 204 | 766 | DNA |
Tgene | TOP1 | chr11:78239888 | chr20:39721112 | ENST00000361337 | + | 7 | 21 | 488_493 | 204 | 766 | DNA |
Tgene | TOP1 | chr11:78239888 | chr20:39721112 | ENST00000361337 | + | 7 | 21 | 585_587 | 204 | 766 | DNA |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NARS2_TOP1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TOP1 | P11387 | DB00762 | Irinotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
Tgene | TOP1 | P11387 | DB01030 | Topotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
Tgene | TOP1 | P11387 | DB05630 | Sodium stibogluconate | DNA topoisomerase 1 | small molecule | approved|investigational |
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RelatedDiseases for NARS2_TOP1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NARS2 | C0023264 | Leigh Disease | 1 | UNIPROT |
Hgene | NARS2 | C4015643 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 24 | 1 | ORPHANET;UNIPROT |
Tgene | TOP1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |