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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 23436

FusionGeneSummary for NARS2_TOP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NARS2_TOP1
Fusion gene ID: 23436
HgeneTgene
Gene symbol

NARS2

TOP1

Gene ID

79731

7150

Gene nameasparaginyl-tRNA synthetase 2, mitochondrialDNA topoisomerase I
SynonymsDFNB94|SLM5|asnRSTOPI
Cytomap

11q14.1

20q12

Type of geneprotein-codingprotein-coding
Descriptionprobable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrialDNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerase
Modification date2018051920180523
UniProtAcc

Q96I59

P11387

Ensembl transtripts involved in fusion geneENST00000281038, ENST00000528850, 
ENST00000361337, 
Fusion gene scores* DoF score12 X 8 X 5=4806 X 5 X 3=90
# samples 136
** MAII scorelog2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NARS2 [Title/Abstract] AND TOP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTOP1

GO:0006265

DNA topological change

14594810


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0HL-01ANARS2chr11

78239888

-TOP1chr20

39721112

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000281038ENST00000361337NARS2chr11

78239888

-TOP1chr20

39721112

+
In-frameENST00000528850ENST00000361337NARS2chr11

78239888

-TOP1chr20

39721112

+

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FusionProtFeatures for NARS2_TOP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NARS2

Q96I59

TOP1

P11387


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTOP1chr11:78239888chr20:39721112ENST00000361337+72123_204204766Compositional biasNote=Lys-rich


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FusionGeneSequence for NARS2_TOP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NARS2_ENST00000281038_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_791aa
MLGVRCLLRSVRFCSSAPFPKHKPSAKLSVRDALGAQNASGERIKIQGWIRSVRSQKEVLFLHVNDGSSLESLQVVADSGLDSRELNFGS
SVEVQGQLIKSPSKRQNVELKAEKIKVIGNCDAKDFPIKYKERHPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHT
PIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAFLTVSGQLHLEVMSGWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGK
VMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLL
KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIK
YIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLH
PELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKEL
TAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLE

>In-frame_NARS2_ENST00000528850_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_564aa
MSGWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKN
IITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDI
IINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKV
RQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPED
DLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKID
AKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NARS2_ENST00000281038_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_2373nt
ATGCTGGGGGTCCGCTGCCTGCTGCGGTCCGTGCGCTTCTGTTCCTCCGCCCCCTTCCCCAAGCACAAACCTTCAGCCAAACTGAGCGTG
CGGGACGCTCTCGGGGCTCAGAACGCGAGTGGGGAGCGCATTAAGATCCAGGGATGGATTCGTTCTGTCCGATCCCAGAAGGAAGTCTTG
TTCCTGCATGTAAATGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGAATTAAATTTTGGGAGT
TCTGTGGAAGTACAAGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAATTAAAGTTATTGGAAAT
TGTGATGCCAAGGATTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTTTAGGTGTAGGACTAAC
GTTCTGGGTTCTATATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTTTGTACATATTCATACT
CCAATAATCACATCCAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGTACCTGAGGAGAATTTC
TTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGGTGGGAAGAAGAGCGCTATCCTGAAGGCATC
AAGTGGAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAA
GTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTACCAAGGAAATATTTAGG
AAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATG
AGCCAGTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTG
AAAGAATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGC
AACCACCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCT
CCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAA
TACATCATGCTTAACCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAGAAATACGAGACTGCTCGGCGGCTGAAAAAATGTGTGGAC
AAGATCCGGAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCCCTGTACTTCATCGACAAGCTT
GCTCTGAGAGCAGGCAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTGGGCTGCTGCTCACTTCGTGTGGAGCACATCAATCTACAC
CCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAGGACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAA
CGAGTTTTTAAGAACCTACAACTATTTATGGAGAACAAGCAGCCCGAGGATGATCTTTTTGATAGACTCAATACTGGTATTCTGAATAAG
CATCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGCTACAGCAGCAGCTAAAAGAACTG
ACAGCCCCGGATGAGAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCCAATCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCA
CCACCAAAAACTTTTGAGAAGTCTATGATGAACTTGCAAACTAAGATTGATGCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTG
AAAAGTGCTAAGGCTGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAGGTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAG
GAACAGTTGATGAAGCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAACAGATTGCCCTGGGAACCTCCAAACTCAATTATCTGGAC
CCTAGGATCACAGTGGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAGATTTACAACAAAACCCAGCGGGAGAAGTTTGCCTGGGCC

>In-frame_NARS2_ENST00000528850_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_1692nt
ATGTCAGGGTGGGAAGAAGAGCGCTATCCTGAAGGCATCAAGTGGAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAG
CCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAA
ATGCTCGACCATGAATATACTACCAAGGAAATATTTAGGAAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAAT
ATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATGAGCCAGTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAA
GAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTGAAAGAATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAAC
TTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGCAACCACCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATA
ATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGG
CTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAATACATCATGCTTAACCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAG
AAATACGAGACTGCTCGGCGGCTGAAAAAATGTGTGGACAAGATCCGGAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTC
CGGCAGAGAGCTGTAGCCCTGTACTTCATCGACAAGCTTGCTCTGAGAGCAGGCAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTG
GGCTGCTGCTCACTTCGTGTGGAGCACATCAATCTACACCCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAG
GACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAACGAGTTTTTAAGAACCTACAACTATTTATGGAGAACAAGCAGCCCGAGGAT
GATCTTTTTGATAGACTCAATACTGGTATTCTGAATAAGCATCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTATTCCGTACATAC
AATGCCTCCATCACGCTACAGCAGCAGCTAAAAGAACTGACAGCCCCGGATGAGAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCC
AATCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTTTTGAGAAGTCTATGATGAACTTGCAAACTAAGATTGAT
GCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTGAAAAGTGCTAAGGCTGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAG
GTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAGGAACAGTTGATGAAGCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAA
CAGATTGCCCTGGGAACCTCCAAACTCAATTATCTGGACCCTAGGATCACAGTGGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NARS2_ENST00000281038_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_3939nt
GTAGCGTGATGACGTAAGCGGCGTTGGCGTGGTGTGGTAGGAGTGGTTGCGCGTGTTGCGGCCCGGGTTCTGTTCGTAGGTTTACAATTG
TCGCGGGTAGTGGGGCGCCCCAGCTGCCAACTGCACGTGGTTTCTTTCTGGCGTTTGCCTAGTGTCCTGTCCATTCCGCCCCGTTGGGAA
GTGGGAAGCGGAGAGGTTCTGTGGGGACAGAGCTGGGAGTCCTGAAGGAGAAAGCGCGCAGCCGAGGGGCTCTGGAGTGCCTTAGAGCAG
AGCTGCGGCCGCGGAAGGGGAGCAGCTGAGAAAGGAGGGCCGCTGCAGGCGGGGTTCGAACCGTGGGGTCTGGGCTGCTCCCGCGGAGGG
CCTGGGCGGACGCGGGATGCTGGGGGTCCGCTGCCTGCTGCGGTCCGTGCGCTTCTGTTCCTCCGCCCCCTTCCCCAAGCACAAACCTTC
AGCCAAACTGAGCGTGCGGGACGCTCTCGGGGCTCAGAACGCGAGTGGGGAGCGCATTAAGATCCAGGGATGGATTCGTTCTGTCCGATC
CCAGAAGGAAGTCTTGTTCCTGCATGTAAATGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGA
ATTAAATTTTGGGAGTTCTGTGGAAGTACAAGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAAT
TAAAGTTATTGGAAATTGTGATGCCAAGGATTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTT
TAGGTGTAGGACTAACGTTCTGGGTTCTATATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTT
TGTACATATTCATACTCCAATAATCACATCCAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGT
ACCTGAGGAGAATTTCTTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGGTGGGAAGAAGAGCG
CTATCCTGAAGGCATCAAGTGGAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTT
TTATTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTAC
CAAGGAAATATTTAGGAAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATG
TGATTTTACCCAGATGAGCCAGTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGA
GAATGAAAAATTACTGAAAGAATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACT
TTTCCGTGGCCGCGGCAACCACCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGC
CAAGGTTCCTTCTCCTCCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACAT
CCAAGGTTCCATTAAATACATCATGCTTAACCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAGAAATACGAGACTGCTCGGCGGCT
GAAAAAATGTGTGGACAAGATCCGGAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCCCTGTA
CTTCATCGACAAGCTTGCTCTGAGAGCAGGCAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTGGGCTGCTGCTCACTTCGTGTGGA
GCACATCAATCTACACCCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAGGACTCCATCAGATACTATAACAA
GGTCCCTGTTGAGAAACGAGTTTTTAAGAACCTACAACTATTTATGGAGAACAAGCAGCCCGAGGATGATCTTTTTGATAGACTCAATAC
TGGTATTCTGAATAAGCATCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGCTACAGCA
GCAGCTAAAAGAACTGACAGCCCCGGATGAGAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCCAATCGAGCTGTTGCAATTCTTTG
TAACCATCAGAGGGCACCACCAAAAACTTTTGAGAAGTCTATGATGAACTTGCAAACTAAGATTGATGCCAAGAAGGAACAGCTAGCAGA
TGCCCGGAGAGACCTGAAAAGTGCTAAGGCTGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAGGTAGTAGAGTCAAAGAAGAAGGC
TGTTCAGAGACTGGAGGAACAGTTGATGAAGCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAACAGATTGCCCTGGGAACCTCCAA
ACTCAATTATCTGGACCCTAGGATCACAGTGGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAGATTTACAACAAAACCCAGCGGGA
GAAGTTTGCCTGGGCCATTGACATGGCTGATGAAGACTATGAGTTTTAGCCAGTCTCAAGAGGCAGAGTTCTGTGAAGAGGAACAGTGTG
GTTTGGGAAAGATGGATAAACTGAGCCTCACTTGCCCTCGTGCCTGGGGGAGAGAGGCAGCAAGTCTTAACAAACCAACATCTTTGCGAA
AAGATAAACCTGGAGATATTATAAGGGAGAGCTGAGCCAGTTGTCCTATGGACAACTTATTTAAAAATATTTCAGATATCAAAATTCTAG
CTGTATGATTTGTTTTGAATTTTGTTTTTATTTTCAAGAGGGCAAGTGGATGGGAATTTGTCAGCGTTCTACCAGGCAAATTCACTGTTT
CACTGAAATGTTTGGATTCTCTTAGCTACTGTATGCAAAGTCCGATTATATTGGTGCGTTTTTACAGTTAGGGTTTTGCAATAACTTCTA
TATTTTAATAGAAATAAATTCCTAAACTCCCTTCCCTCTCTCCCATTTCAGGAATTTAAAATTAAGTAGAACAAAAAACCCAGCGCACCT
GTTAGAGTCGTCACTCTCTATTGTCATGGGGATCAATTTTCATTAAACTTGAAGCAGTCGTGGCTTTGGCAGTGTTTTGGTTCAGACACC
TGTTCACAGAAAAAGCATGATGGGAAAATATTTCCTGACTTGAGTGTTCCTTTTTAAATGTGAATTTTTATTTCTTTTTAATTATTTTAA
AATATTTAAACCTTTTTCTTGATCTTAAAGATCGTGTAGATTGGGGTTGGGGAGGGATGAAGGGCGAGTGAATCTAAGGATAATGAAATA
ATCAGTGACTGAAACCATTTTCCCATCATCCTTTGTTCTGAGCATTCGCTGTACCCTTTAAGATATCCATCTTTTTCTTTTTAACCCTAA
TCTTTCACTTGAAAGATTTTATTGTATAAAAAGTTTCACAGGTCAATAAACTTAGAGGAAAATGAGTATTTGGTCCAAAAAAAGGAAAAA
TAATCAAGATTTTAGGGCTTTTATTTTTTCTTTTGTAATTGTGTAAAAAATGGAAAAAAACATAAAAAGCAGAATTTTAATGTGAAGACA
TTTTTTGCTATAATCATTAGTTTTAGAGGCATTGTTAGTTTAGTGTGTGTGCAGAGTCCATTTCCCACATCTTTCCTCAAGTATCTTCTA

>In-frame_NARS2_ENST00000528850_chr11_78239888_-_TOP1_ENST00000361337_chr20_39721112_+_3819nt
AGGGTCTAGCTCTGTCACCCAGACTGGAGCGCAGTGATGTGATCTCAGATGACTACAACCTCCATCTCCCAGGCTCAAGCAATCCTCCTG
CCTCGGCCTCCAGAGTAGCTGAAACTATAGGCATGCACCACCACACTCTATAATTTTTTAAGTTTTTTGTGAAGATGAGTCTCACTGTAT
TGCCCAGGCTGGTCTCAAACTCCTGGACTCAAGCAGTCCTCCTCCTTCGGCATCCCAAAATGCTGGGATTACAGGCATAAGCCTGGTAGA
TGTTGTTATAATAAATACTTATTTTTTGAGTAGGTTCTTGCTTTGTCACCCATGATTGTACTGACACAGTCATGGCTTGCCGTTGCAGTG
ATTTCTGTTGTCCTCACATATCCTTTACTTTTTAGCGGGATGGATTCGTTCTGTCCGATCCCAGAAGGAAGTCTTGTTCCTGCATGTAAA
TGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGAATTAAATTTTGGGAGTTCTGTGGAAGTACA
AGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAATTAAAGTTATTGGAAATTGTGATGCCAAGGA
TTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTTTAGGTGTAGGACTAACGTTCTGGGTTCTAT
ATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTTTGTACATATTCATACTCCAATAATCACATC
CAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGTACCTGAGGAGAATTTCTTCAATGTTCCTGC
TTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGGTGGGAAGAAGAGCGCTATCCTGAAGGCATCAAGTGGAAATTCCT
AGAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAAGTCATGAAGCTGAG
CCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTACCAAGGAAATATTTAGGAAAAATTTCTTTAA
AGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATGAGCCAGTATTTCAA
AGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTGAAAGAATATGGATT
CTGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGCAACCACCCCAAGAT
GGGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCCAGGACATAA
GTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAATACATCATGCTTAA
CCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAGAAATACGAGACTGCTCGGCGGCTGAAAAAATGTGTGGACAAGATCCGGAACCA
GTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCCCTGTACTTCATCGACAAGCTTGCTCTGAGAGCAGG
CAATGAAAAGGAGGAAGGAGAAACAGCGGACACTGTGGGCTGCTGCTCACTTCGTGTGGAGCACATCAATCTACACCCAGAGTTGGATGG
TCAGGAATATGTGGTAGAGTTTGACTTCCTCGGGAAGGACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAACGAGTTTTTAAGAA
CCTACAACTATTTATGGAGAACAAGCAGCCCGAGGATGATCTTTTTGATAGACTCAATACTGGTATTCTGAATAAGCATCTTCAGGATCT
CATGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGCTACAGCAGCAGCTAAAAGAACTGACAGCCCCGGATGA
GAACATCCCAGCGAAGATCCTTTCTTATAACCGTGCCAATCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTTT
TGAGAAGTCTATGATGAACTTGCAAACTAAGATTGATGCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTGAAAAGTGCTAAGGC
TGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAAGGTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAGGAACAGTTGATGAA
GCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAACAGATTGCCCTGGGAACCTCCAAACTCAATTATCTGGACCCTAGGATCACAGT
GGCTTGGTGCAAGAAGTGGGGTGTCCCAATTGAGAAGATTTACAACAAAACCCAGCGGGAGAAGTTTGCCTGGGCCATTGACATGGCTGA
TGAAGACTATGAGTTTTAGCCAGTCTCAAGAGGCAGAGTTCTGTGAAGAGGAACAGTGTGGTTTGGGAAAGATGGATAAACTGAGCCTCA
CTTGCCCTCGTGCCTGGGGGAGAGAGGCAGCAAGTCTTAACAAACCAACATCTTTGCGAAAAGATAAACCTGGAGATATTATAAGGGAGA
GCTGAGCCAGTTGTCCTATGGACAACTTATTTAAAAATATTTCAGATATCAAAATTCTAGCTGTATGATTTGTTTTGAATTTTGTTTTTA
TTTTCAAGAGGGCAAGTGGATGGGAATTTGTCAGCGTTCTACCAGGCAAATTCACTGTTTCACTGAAATGTTTGGATTCTCTTAGCTACT
GTATGCAAAGTCCGATTATATTGGTGCGTTTTTACAGTTAGGGTTTTGCAATAACTTCTATATTTTAATAGAAATAAATTCCTAAACTCC
CTTCCCTCTCTCCCATTTCAGGAATTTAAAATTAAGTAGAACAAAAAACCCAGCGCACCTGTTAGAGTCGTCACTCTCTATTGTCATGGG
GATCAATTTTCATTAAACTTGAAGCAGTCGTGGCTTTGGCAGTGTTTTGGTTCAGACACCTGTTCACAGAAAAAGCATGATGGGAAAATA
TTTCCTGACTTGAGTGTTCCTTTTTAAATGTGAATTTTTATTTCTTTTTAATTATTTTAAAATATTTAAACCTTTTTCTTGATCTTAAAG
ATCGTGTAGATTGGGGTTGGGGAGGGATGAAGGGCGAGTGAATCTAAGGATAATGAAATAATCAGTGACTGAAACCATTTTCCCATCATC
CTTTGTTCTGAGCATTCGCTGTACCCTTTAAGATATCCATCTTTTTCTTTTTAACCCTAATCTTTCACTTGAAAGATTTTATTGTATAAA
AAGTTTCACAGGTCAATAAACTTAGAGGAAAATGAGTATTTGGTCCAAAAAAAGGAAAAATAATCAAGATTTTAGGGCTTTTATTTTTTC
TTTTGTAATTGTGTAAAAAATGGAAAAAAACATAAAAAGCAGAATTTTAATGTGAAGACATTTTTTGCTATAATCATTAGTTTTAGAGGC
ATTGTTAGTTTAGTGTGTGTGCAGAGTCCATTTCCCACATCTTTCCTCAAGTATCTTCTATTTTTATCATGAATTCCCTTTTAATCAACT


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FusionGenePPI for NARS2_TOP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NARS2SLC25A41, OXLD1, DARS2, ADRBK1, CHCHD2, RAB8B, PDK4, LAMP3, NDUFS7, HSPD1, ACSM5, TRNT1, CD70, YBEY, TMEM70, NIT1, GATC, CLEC2D, FOXRED1, OTC, BPNT1, CHRM3TOP1CSNK2A1, CSNK2A2, TP53, TAL1, NCL, SRSF1, BTBD1, BTBD2, TOPORS, SRSF11, SFPQ, UBE2I, CDT1, CDKN2A, RRP1B, H2AFY, PMS1, MGMT, HIST1H3E, H3F3A, MYC, ICT1, HDAC5, NOP56, NPM1, FBL, HIST1H1C, H1FX, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, HNRNPR, ELAVL1, MKI67, NAT10, DHX9, NOP2, NONO, PARP1, DDX21, DDX17, SF3B3, SF3B1, TCOF1, SNRPA1, DDX23, EFTUD2, SNRNP200, PRPF8, OAS3, EIF2AK2, PCNA, HDGF, SIRT7, GTF3C1, XRCC5, CUL3, CDK2, CUL1, COPS5, CAND1, DDB2, ERCC8, ATM, IRF4, BARD1, ELK3, TARBP2, KMT2A, IRF8, IRF9, SNW1, PRB1, SNRNP70, U2AF2, LSM4, GEMIN4, CDK8, BUB3, RBL1, RBL2, GRWD1, SYMPK, JAK1, LIG4, PPP2R2B, TRIM32, RCVRN, PYGM, APAF1, CKAP5, TUBD1, PDE10A, APP, HNRNPM, RPS14, SNRPD1, IK, RBM39, SF3B6, SUPT16H, UTP20, S100A9, NCSTN, RBM14, TPR, ESR1, NKX3-1, VCP, PA2G4, VCAM1, IL7R, ITGA4, HDAC9, CDK14, TARDBP, SHFM1, ERG, MDM2, CUL7, OBSL1, EED, RNF2, EAF1, ZRANB2, APLF, NTRK1, RBM25, PWP1, RBM28, TOP2A, TOP2B, SCARNA22, FSHR, SRPK2, LAMB3, TRIM26, NLRP3, MCM5, NF2, CDC5L, PES1, POU5F1, EGFR, FNTA, ARID1A, PDGFRA, ROR1, PBRM1, TSC1, ERBB2, MTOR, BRCA1, CDK4, ESAM, CIDEC, SNRPG, PRICKLE3, DUS4L, GTF2E2, NR3C1, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, PDHA1, VDAC1, TRIM25, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTOP1chr11:78239888chr20:39721112ENST00000361337+721425_426204766DNA
TgeneTOP1chr11:78239888chr20:39721112ENST00000361337+721488_493204766DNA
TgeneTOP1chr11:78239888chr20:39721112ENST00000361337+721585_587204766DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NARS2_TOP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTOP1P11387DB00762IrinotecanDNA topoisomerase 1small moleculeapproved|investigational
TgeneTOP1P11387DB01030TopotecanDNA topoisomerase 1small moleculeapproved|investigational
TgeneTOP1P11387DB05630Sodium stibogluconateDNA topoisomerase 1small moleculeapproved|investigational

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RelatedDiseases for NARS2_TOP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNARS2C0023264Leigh Disease1UNIPROT
HgeneNARS2C4015643COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 241ORPHANET;UNIPROT
TgeneTOP1C0041755Adverse reaction to drug1CTD_human