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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23404

FusionGeneSummary for NAPA_PPP5D1

check button Fusion gene summary
Fusion gene informationFusion gene name: NAPA_PPP5D1
Fusion gene ID: 23404
HgeneTgene
Gene symbol

NAPA

PPP5D1

Gene ID

9476

100506012

Gene namenapsin A aspartic peptidasePPP5 tetratricopeptide repeat domain containing 1
SynonymsKAP|Kdap|NAP1|NAPA|SNAPA-
Cytomap

19q13.33

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionnapsin-AASP4TA01/TA02asp 4aspartyl protease 4kidney-derived aspartic protease-like proteinnapsin-1pronapsin Aprotein PPP5D1PPP5 TPR repeat domain-containing protein 1
Modification date2018052320180519
UniProtAcc

P54920

E7EU14

Ensembl transtripts involved in fusion geneENST00000263354, ENST00000595227, 
ENST00000593785, 
ENST00000414155, 
ENST00000595691, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: NAPA [Title/Abstract] AND PPP5D1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAPA

GO:0033619

membrane protein proteolysis

14766755

HgeneNAPA

GO:0043129

surfactant homeostasis

18216060


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A9RU-01ANAPAchr19

48018100

-PPP5D1chr19

46984697

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263354ENST00000414155NAPAchr19

48018100

-PPP5D1chr19

46984697

-
5CDS-5UTRENST00000263354ENST00000595691NAPAchr19

48018100

-PPP5D1chr19

46984697

-
5CDS-intronENST00000595227ENST00000414155NAPAchr19

48018100

-PPP5D1chr19

46984697

-
5CDS-5UTRENST00000595227ENST00000595691NAPAchr19

48018100

-PPP5D1chr19

46984697

-
5UTR-intronENST00000593785ENST00000414155NAPAchr19

48018100

-PPP5D1chr19

46984697

-
5UTR-5UTRENST00000593785ENST00000595691NAPAchr19

48018100

-PPP5D1chr19

46984697

-

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FusionProtFeatures for NAPA_PPP5D1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAPA

P54920

PPP5D1

E7EU14

Required for vesicular transport between the endoplasmicreticulum and the Golgi apparatus (Probable). Together with GNA12promotes CDH5 localization to plasma membrane (PubMed:15980433).{ECO:0000269|PubMed:15980433, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAPA_PPP5D1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAPA_PPP5D1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAPARTN4, STX5, SNAP23, STX4, VAMP8, STX12, STX7, STX1A, STX8, NSF, SNAP25, VAMP2, APP, DHX40, THUMPD3, STAM2, DHX29, VCP, FN1, VCAM1, ITGA4, ATP4A, RPA3, RPA2, RPA1, RNF2, VTI1B, STX6, USE1, NAPG, TMEM171, SLC30A4, HSPB1, AP2A2, ATP6V1B2, BET1, HSPA4L, HYOU1, CAPZB, SNAP29, UNC45A, STX16, TRMT6, KRAS, VAMP4, SEC22B, STXBP6, RINT1PPP5D1DUSP8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAPA_PPP5D1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAPA_PPP5D1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource