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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23403

FusionGeneSummary for NAPA_PLAC1

check button Fusion gene summary
Fusion gene informationFusion gene name: NAPA_PLAC1
Fusion gene ID: 23403
HgeneTgene
Gene symbol

NAPA

PLAC1

Gene ID

9476

10761

Gene namenapsin A aspartic peptidaseplacenta specific 1
SynonymsKAP|Kdap|NAP1|NAPA|SNAPACT92|OOSP2L
Cytomap

19q13.33

Xq26.3

Type of geneprotein-codingprotein-coding
Descriptionnapsin-AASP4TA01/TA02asp 4aspartyl protease 4kidney-derived aspartic protease-like proteinnapsin-1pronapsin Aplacenta-specific protein 1cancer/testis antigen 92
Modification date2018052320180519
UniProtAcc

P54920

Q9HBJ0

Ensembl transtripts involved in fusion geneENST00000263354, ENST00000595227, 
ENST00000593785, 
ENST00000476971, 
ENST00000359237, 
Fusion gene scores* DoF score3 X 2 X 3=183 X 2 X 2=12
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NAPA [Title/Abstract] AND PLAC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAPA

GO:0033619

membrane protein proteolysis

14766755

HgeneNAPA

GO:0043129

surfactant homeostasis

18216060


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-IE-A4EH-01ANAPAchr19

48018100

-PLAC1chrX

133700770

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263354ENST00000476971NAPAchr19

48018100

-PLAC1chrX

133700770

-
5CDS-5UTRENST00000263354ENST00000359237NAPAchr19

48018100

-PLAC1chrX

133700770

-
5CDS-5UTRENST00000595227ENST00000476971NAPAchr19

48018100

-PLAC1chrX

133700770

-
5CDS-5UTRENST00000595227ENST00000359237NAPAchr19

48018100

-PLAC1chrX

133700770

-
5UTR-5UTRENST00000593785ENST00000476971NAPAchr19

48018100

-PLAC1chrX

133700770

-
5UTR-5UTRENST00000593785ENST00000359237NAPAchr19

48018100

-PLAC1chrX

133700770

-

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FusionProtFeatures for NAPA_PLAC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAPA

P54920

PLAC1

Q9HBJ0

Required for vesicular transport between the endoplasmicreticulum and the Golgi apparatus (Probable). Together with GNA12promotes CDH5 localization to plasma membrane (PubMed:15980433).{ECO:0000269|PubMed:15980433, ECO:0000305}. May play a role in placental development.{ECO:0000269|PubMed:10995572}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAPA_PLAC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAPA_PLAC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAPARTN4, STX5, SNAP23, STX4, VAMP8, STX12, STX7, STX1A, STX8, NSF, SNAP25, VAMP2, APP, DHX40, THUMPD3, STAM2, DHX29, VCP, FN1, VCAM1, ITGA4, ATP4A, RPA3, RPA2, RPA1, RNF2, VTI1B, STX6, USE1, NAPG, TMEM171, SLC30A4, HSPB1, AP2A2, ATP6V1B2, BET1, HSPA4L, HYOU1, CAPZB, SNAP29, UNC45A, STX16, TRMT6, KRAS, VAMP4, SEC22B, STXBP6, RINT1PLAC1EP400, MEAF6, EPC2, TRRAP, BRD8, VPS72, ING3, DMAP1, OBSL1, EPC1, TADA1, MBTD1, MRGBP, KAT5, YEATS4, SUPT7L, MORF4L1, TAF5L, SUPT20H, KAT2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAPA_PLAC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAPA_PLAC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource