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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23402

FusionGeneSummary for NAPA_CTSB

check button Fusion gene summary
Fusion gene informationFusion gene name: NAPA_CTSB
Fusion gene ID: 23402
HgeneTgene
Gene symbol

NAPA

CTSB

Gene ID

9476

1508

Gene namenapsin A aspartic peptidasecathepsin B
SynonymsKAP|Kdap|NAP1|NAPA|SNAPAAPPS|CPSB
Cytomap

19q13.33

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionnapsin-AASP4TA01/TA02asp 4aspartyl protease 4kidney-derived aspartic protease-like proteinnapsin-1pronapsin Acathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine protease
Modification date2018052320180523
UniProtAcc

P54920

P07858

Ensembl transtripts involved in fusion geneENST00000263354, ENST00000595227, 
ENST00000593785, 
ENST00000434271, 
ENST00000353047, ENST00000530640, 
ENST00000531089, ENST00000453527, 
ENST00000415599, ENST00000345125, 
ENST00000533455, ENST00000534510, 
ENST00000525076, 
Fusion gene scores* DoF score3 X 2 X 3=188 X 8 X 2=128
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/128*10)=-0.508146903670325
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAPA [Title/Abstract] AND CTSB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAPA

GO:0033619

membrane protein proteolysis

14766755

HgeneNAPA

GO:0043129

surfactant homeostasis

18216060

TgeneCTSB

GO:0006508

proteolysis

7890620|8811434

TgeneCTSB

GO:0030574

collagen catabolic process

22952693

TgeneCTSB

GO:0051603

proteolysis involved in cellular protein catabolic process

22952693


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTHCATCGA-DJ-A13S-01ANAPAchr19

47990894

-CTSBchr8

11702567

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263354ENST00000434271NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-3UTRENST00000263354ENST00000353047NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-intronENST00000263354ENST00000530640NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-intronENST00000263354ENST00000531089NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-3UTRENST00000263354ENST00000453527NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-3UTRENST00000263354ENST00000415599NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-3UTRENST00000263354ENST00000345125NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-3UTRENST00000263354ENST00000533455NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-3UTRENST00000263354ENST00000534510NAPAchr19

47990894

-CTSBchr8

11702567

-
5CDS-intronENST00000263354ENST00000525076NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000595227ENST00000434271NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000595227ENST00000353047NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-intronENST00000595227ENST00000530640NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-intronENST00000595227ENST00000531089NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000595227ENST00000453527NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000595227ENST00000415599NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000595227ENST00000345125NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000595227ENST00000533455NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000595227ENST00000534510NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-intronENST00000595227ENST00000525076NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000593785ENST00000434271NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000593785ENST00000353047NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-intronENST00000593785ENST00000530640NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-intronENST00000593785ENST00000531089NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000593785ENST00000453527NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000593785ENST00000415599NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000593785ENST00000345125NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000593785ENST00000533455NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-3UTRENST00000593785ENST00000534510NAPAchr19

47990894

-CTSBchr8

11702567

-
intron-intronENST00000593785ENST00000525076NAPAchr19

47990894

-CTSBchr8

11702567

-

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FusionProtFeatures for NAPA_CTSB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAPA

P54920

CTSB

P07858

Required for vesicular transport between the endoplasmicreticulum and the Golgi apparatus (Probable). Together with GNA12promotes CDH5 localization to plasma membrane (PubMed:15980433).{ECO:0000269|PubMed:15980433, ECO:0000305}. Thiol protease which is believed to participate inintracellular degradation and turnover of proteins. Has also beenimplicated in tumor invasion and metastasis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAPA_CTSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAPA_CTSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAPARTN4, STX5, SNAP23, STX4, VAMP8, STX12, STX7, STX1A, STX8, NSF, SNAP25, VAMP2, APP, DHX40, THUMPD3, STAM2, DHX29, VCP, FN1, VCAM1, ITGA4, ATP4A, RPA3, RPA2, RPA1, RNF2, VTI1B, STX6, USE1, NAPG, TMEM171, SLC30A4, HSPB1, AP2A2, ATP6V1B2, BET1, HSPA4L, HYOU1, CAPZB, SNAP29, UNC45A, STX16, TRMT6, KRAS, VAMP4, SEC22B, STXBP6, RINT1CTSBCSTA, CSTB, CST3, BAG6, S100A10, ANXA2, UBQLN4, USP29, DMWD, FAM118B, SPRY2, CDKN1A, RGS2, ANXA7, SH3KBP1, APP, PROCR, PARP1, MLH1, METTL21B, HNRNPD, XRN1, HIPK4, CDK18, FBXO6, IRS4, UNK, MSI2, HSPB2, STK11, CEP164, FBF1, RPGRIP1L, SCLT1, CDH1, PTPN18, NR3C1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAPA_CTSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAPA_CTSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCTSBC0027626Neoplasm Invasiveness2CTD_human
TgeneCTSBC0007134Renal Cell Carcinoma1CTD_human
TgeneCTSBC0017636Glioblastoma1CTD_human
TgeneCTSBC0026848Myopathy1CTD_human
TgeneCTSBC0027540Necrosis1CTD_human
TgeneCTSBC0033578Prostatic Neoplasms1CTD_human
TgeneCTSBC0033687Proteinuria1CTD_human