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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23399

FusionGeneSummary for NAP1L4_NAP1L4

check button Fusion gene summary
Fusion gene informationFusion gene name: NAP1L4_NAP1L4
Fusion gene ID: 23399
HgeneTgene
Gene symbol

NAP1L4

NAP1L4

Gene ID

4676

4676

Gene namenucleosome assembly protein 1 like 4nucleosome assembly protein 1 like 4
SynonymsNAP1L4b|NAP2|NAP2L|hNAP2NAP1L4b|NAP2|NAP2L|hNAP2
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionnucleosome assembly protein 1-like 4NAP-2nucleosome assembly protein 1-like 4bnucleosome assembly protein 2nucleosome assembly protein 1-like 4NAP-2nucleosome assembly protein 1-like 4bnucleosome assembly protein 2
Modification date2018051920180519
UniProtAcc

Q99733

Q99733

Ensembl transtripts involved in fusion geneENST00000380542, ENST00000469089, 
ENST00000526115, 
ENST00000380542, 
ENST00000469089, ENST00000526115, 
Fusion gene scores* DoF score8 X 9 X 5=3603 X 5 X 1=15
# samples 105
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/15*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NAP1L4 [Title/Abstract] AND NAP1L4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAP1L4

GO:0006334

nucleosome assembly

9325046

TgeneNAP1L4

GO:0006334

nucleosome assembly

9325046


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB239547NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
ChiTaRS3.1AW835788NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
ChiTaRS3.1BX113409NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380542ENST00000380542NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000380542ENST00000469089NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000380542ENST00000526115NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000469089ENST00000380542NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000469089ENST00000469089NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000469089ENST00000526115NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000526115ENST00000380542NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000526115ENST00000469089NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000526115ENST00000526115NAP1L4chr11

2966413

-NAP1L4chr11

2969637

-
intron-intronENST00000380542ENST00000380542NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000380542ENST00000469089NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000380542ENST00000526115NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000469089ENST00000380542NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000469089ENST00000469089NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000469089ENST00000526115NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000526115ENST00000380542NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000526115ENST00000469089NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000526115ENST00000526115NAP1L4chr11

3003681

+NAP1L4chr11

3003239

-
intron-intronENST00000380542ENST00000380542NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
intron-intronENST00000380542ENST00000469089NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
intron-intronENST00000380542ENST00000526115NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
intron-intronENST00000469089ENST00000380542NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
intron-intronENST00000469089ENST00000469089NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
intron-intronENST00000469089ENST00000526115NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
intron-intronENST00000526115ENST00000380542NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
intron-intronENST00000526115ENST00000469089NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-
intron-intronENST00000526115ENST00000526115NAP1L4chr11

2987134

-NAP1L4chr11

2988569

-

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FusionProtFeatures for NAP1L4_NAP1L4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAP1L4

Q99733

NAP1L4

Q99733

Acts as histone chaperone in nucleosome assembly.{ECO:0000269|PubMed:9325046}. Acts as histone chaperone in nucleosome assembly.{ECO:0000269|PubMed:9325046}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAP1L4_NAP1L4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAP1L4_NAP1L4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAP1L4_NAP1L4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAP1L4_NAP1L4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAP1L4C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNAP1L4C0001973Alcoholic Intoxication, Chronic1PSYGENET