FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23398

FusionGeneSummary for NAP1L4_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: NAP1L4_MBP
Fusion gene ID: 23398
HgeneTgene
Gene symbol

NAP1L4

MBP

Gene ID

4676

5553

Gene namenucleosome assembly protein 1 like 4proteoglycan 2, pro eosinophil major basic protein
SynonymsNAP1L4b|NAP2|NAP2L|hNAP2BMPG|MBP|MBP1|proMBP
Cytomap

11p15.4

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionnucleosome assembly protein 1-like 4NAP-2nucleosome assembly protein 1-like 4bnucleosome assembly protein 2bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018051920180519
UniProtAcc

Q99733

P02686

Ensembl transtripts involved in fusion geneENST00000380542, ENST00000469089, 
ENST00000526115, 
ENST00000382582, 
ENST00000355994, ENST00000397875, 
ENST00000397866, ENST00000397865, 
ENST00000527041, ENST00000359645, 
ENST00000528160, ENST00000397869, 
ENST00000354542, ENST00000526111, 
ENST00000580402, ENST00000579129, 
ENST00000578193, ENST00000397863, 
ENST00000397860, ENST00000487778, 
Fusion gene scores* DoF score8 X 9 X 5=36026 X 20 X 3=1560
# samples 1027
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAP1L4 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAP1L4

GO:0006334

nucleosome assembly

9325046


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA264641NAP1L4chr11

2985001

-MBPchr18

74729011

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000380542ENST00000382582NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000355994NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000397875NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000397866NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000397865NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000527041NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-intronENST00000380542ENST00000359645NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000528160NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000397869NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000354542NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000526111NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000580402NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000579129NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000578193NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000397863NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000397860NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000380542ENST00000487778NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000382582NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000355994NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000397875NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000397866NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000397865NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000527041NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-intronENST00000469089ENST00000359645NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000528160NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000397869NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000354542NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000526111NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000580402NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000579129NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000578193NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000397863NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000397860NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000469089ENST00000487778NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000382582NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000355994NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000397875NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000397866NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000397865NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000527041NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-intronENST00000526115ENST00000359645NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000528160NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000397869NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000354542NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000526111NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000580402NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000579129NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000578193NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000397863NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000397860NAP1L4chr11

2985001

-MBPchr18

74729011

-
intron-5UTRENST00000526115ENST00000487778NAP1L4chr11

2985001

-MBPchr18

74729011

-

Top

FusionProtFeatures for NAP1L4_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAP1L4

Q99733

MBP

P02686

Acts as histone chaperone in nucleosome assembly.{ECO:0000269|PubMed:9325046}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NAP1L4_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NAP1L4_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NAP1L4_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NAP1L4_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAP1L4C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human