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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23388

FusionGeneSummary for NAP1L1_PTPRR

check button Fusion gene summary
Fusion gene informationFusion gene name: NAP1L1_PTPRR
Fusion gene ID: 23388
HgeneTgene
Gene symbol

NAP1L1

PTPRR

Gene ID

4673

5801

Gene namenucleosome assembly protein 1 like 1protein tyrosine phosphatase, receptor type R
SynonymsNAP1|NAP1L|NRPEC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
Cytomap

12q21.2

12q15

Type of geneprotein-codingprotein-coding
Descriptionnucleosome assembly protein 1-like 1HSP22-like protein interacting proteinNAP-1-related proteinreceptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1
Modification date2018052220180519
UniProtAcc

P55209

Q15256

Ensembl transtripts involved in fusion geneENST00000261182, ENST00000393263, 
ENST00000431879, ENST00000547773, 
ENST00000544816, ENST00000542344, 
ENST00000535020, ENST00000549596, 
ENST00000547993, ENST00000552342, 
ENST00000548044, 
ENST00000283228, 
ENST00000440835, ENST00000537619, 
ENST00000378778, ENST00000342084, 
ENST00000549308, 
Fusion gene scores* DoF score10 X 7 X 4=28033 X 13 X 10=4290
# samples 1231
** MAII scorelog2(12/280*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/4290*10)=-3.79063752711267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAP1L1 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3LT-01ANAP1L1chr12

76478347

-PTPRRchr12

71158558

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261182ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000261182ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000261182ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000261182ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000261182ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000261182ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000393263ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000393263ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000393263ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000393263ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000393263ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000393263ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000431879ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000431879ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000431879ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000431879ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000431879ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000431879ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000547773ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000547773ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000547773ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000547773ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000547773ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000547773ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000544816ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000544816ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000544816ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000544816ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000544816ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000544816ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000542344ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000542344ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000542344ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000542344ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000542344ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000542344ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000535020ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000535020ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000535020ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000535020ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000535020ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000535020ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000549596ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000549596ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000549596ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000549596ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000549596ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000549596ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
intron-3CDSENST00000547993ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
intron-intronENST00000547993ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
intron-intronENST00000547993ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
intron-intronENST00000547993ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
intron-intronENST00000547993ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
intron-intronENST00000547993ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000552342ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000552342ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000552342ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000552342ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000552342ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000552342ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-3CDSENST00000548044ENST00000283228NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000548044ENST00000440835NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000548044ENST00000537619NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000548044ENST00000378778NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000548044ENST00000342084NAP1L1chr12

76478347

-PTPRRchr12

71158558

-
5UTR-intronENST00000548044ENST00000549308NAP1L1chr12

76478347

-PTPRRchr12

71158558

-

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FusionProtFeatures for NAP1L1_PTPRR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAP1L1

P55209

PTPRR

Q15256

May be involved in modulating chromatin formation andcontribute to regulation of cell proliferation. Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAP1L1_PTPRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAP1L1_PTPRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAP1L1NAP1L1, DLST, EP300, UBC, NOP56, CSNK2B, MED10, RAD21, ELAVL1, ARRB2, SIRT7, FBXO25, TERF1, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, COPS2, KCND3, LRRK1, RPL6, RPS6, RPL10A, NPM1, RPS3A, RPL5, RPL15, RPL9, RPL31, RPL11, RPL14, RPL12, RPL37A, RPS4X, RPS3, NAP1L4, PES1, IPO9, SET, PDCD4, UBA2, RPS10P5, CSNK2A1, EIF3C, RBBP4, IQCB1, NOS2, BAG3, TPX2, POT1, NR2F6, PHB, SP1, OSBP, RANBP3, THUMPD1, MAGED2, HUWE1, FUS, CUL7, ILK, JAK2, JAK3, RPL24, NOP16, UBE2O, HIST1H2AG, HIST2H2AB, EIF1AX, FNTA, RPL36AL, RPL36A, RIC8B, RPL17, FNTB, EPB41L5, SDAD1, HIST1H2BA, NAP1L5, LGALS3, HSPB1, ALYREF, C11orf58, CDC23, EIF3H, GTF2B, NCL, SSRP1, SUPT16H, WDR43, SUPT4H1, NTRK1, CEP120, SPICE1, DCTN1, LCA5, RPGRIP1, XPO1, CAPZA2, DBN1, MYH9, PCDHB15, MYO19, QSOX2, ASPM, MCM2, C3orf17, AURKAIP1, H2AFX, RPL18, VTN, MRPL35, GNAS, MTNR1A, CYLD, COX15, DLD, DNM1L, HSD17B10, SOAT1, VDAC1, TRIM25, BRCA1PTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAP1L1_PTPRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAP1L1_PTPRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRRC0041696Unipolar Depression1PSYGENET
TgenePTPRRC1269683Major Depressive Disorder1PSYGENET