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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23375

FusionGeneSummary for NAGS_PYY

check button Fusion gene summary
Fusion gene informationFusion gene name: NAGS_PYY
Fusion gene ID: 23375
HgeneTgene
Gene symbol

NAGS

PYY

Gene ID

162417

5697

Gene nameN-acetylglutamate synthasepeptide YY
SynonymsAGAS|ARGAPYY-I|PYY1
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionN-acetylglutamate synthase, mitochondrialamino-acid acetyltransferasepeptide YYpeptide tyrosine tyrosineprepro-PYY
Modification date2018052320180523
UniProtAcc

Q8N159

P10082

Ensembl transtripts involved in fusion geneENST00000293404, ENST00000360085, 
ENST00000592796, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 1 X 2=6
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/6*10)=2.32192809488736
Context

PubMed: NAGS [Title/Abstract] AND PYY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-A925-01ANAGSchr17

42082457

+PYYchr17

42043900

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000293404ENST00000360085NAGSchr17

42082457

+PYYchr17

42043900

-
5CDS-intronENST00000293404ENST00000592796NAGSchr17

42082457

+PYYchr17

42043900

-

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FusionProtFeatures for NAGS_PYY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAGS

Q8N159

PYY

P10082

Plays a role in the regulation of ureagenesis byproducing the essential cofactor N-acetylglutamate (NAG), thusmodulating carbamoylphosphate synthase I (CPSI) activity. This gut peptide inhibits exocrine pancreatic secretion,has a vasoconstrictory action and inhibitis jejunal and colonicmobility.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAGS_PYY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAGS_PYY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAGSKRASPYYMEP1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAGS_PYY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNAGSQ8N159DB00142Glutamic AcidN-acetylglutamate synthase, mitochondrialsmall moleculeapproved|nutraceutical

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RelatedDiseases for NAGS_PYY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAGSC0220994Hyperammonemia3CTD_human
HgeneNAGSC0268543Hyperammonemia, type III3CTD_human;ORPHANET;UNIPROT
TgenePYYC0011570Mental Depression2PSYGENET
TgenePYYC0011581Depressive disorder2PSYGENET
TgenePYYC0002395Alzheimer's Disease1CTD_human
TgenePYYC0003123Anorexia1CTD_human
TgenePYYC0011991Diarrhea1CTD_human
TgenePYYC0027794Neural Tube Defects1CTD_human
TgenePYYC0028754Obesity1CTD_human