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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23371

FusionGeneSummary for NAGK_NAGK

check button Fusion gene summary
Fusion gene informationFusion gene name: NAGK_NAGK
Fusion gene ID: 23371
HgeneTgene
Gene symbol

NAGK

NAGK

Gene ID

55577

55577

Gene nameN-acetylglucosamine kinaseN-acetylglucosamine kinase
SynonymsGNK|HSA242910GNK|HSA242910
Cytomap

2p13.3

2p13.3

Type of geneprotein-codingprotein-coding
DescriptionN-acetyl-D-glucosamine kinaseglcNAc kinaseN-acetyl-D-glucosamine kinaseglcNAc kinase
Modification date2018051920180519
UniProtAcc

Q9UJ70

Q9UJ70

Ensembl transtripts involved in fusion geneENST00000455662, ENST00000418807, 
ENST00000443872, ENST00000443938, 
ENST00000244204, ENST00000428360, 
ENST00000455662, ENST00000418807, 
ENST00000443872, ENST00000443938, 
ENST00000244204, ENST00000428360, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: NAGK [Title/Abstract] AND NAGK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW748767NAGKchr2

71300374

+NAGKchr2

71300326

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000455662ENST00000455662NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000455662ENST00000418807NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000455662ENST00000443872NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000455662ENST00000443938NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000455662ENST00000244204NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000455662ENST00000428360NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000418807ENST00000455662NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000418807ENST00000418807NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000418807ENST00000443872NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000418807ENST00000443938NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000418807ENST00000244204NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000418807ENST00000428360NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443872ENST00000455662NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443872ENST00000418807NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443872ENST00000443872NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443872ENST00000443938NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443872ENST00000244204NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443872ENST00000428360NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443938ENST00000455662NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443938ENST00000418807NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443938ENST00000443872NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443938ENST00000443938NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443938ENST00000244204NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000443938ENST00000428360NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000244204ENST00000455662NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000244204ENST00000418807NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000244204ENST00000443872NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000244204ENST00000443938NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000244204ENST00000244204NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000244204ENST00000428360NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000428360ENST00000455662NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000428360ENST00000418807NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000428360ENST00000443872NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000428360ENST00000443938NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000428360ENST00000244204NAGKchr2

71300374

+NAGKchr2

71300326

-
intron-intronENST00000428360ENST00000428360NAGKchr2

71300374

+NAGKchr2

71300326

-

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FusionProtFeatures for NAGK_NAGK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAGK

Q9UJ70

NAGK

Q9UJ70

Converts endogenous N-acetylglucosamine (GlcNAc), amajor component of complex carbohydrates, from lysosomaldegradation or nutritional sources into GlcNAc 6-phosphate.Involved in the N-glycolylneuraminic acid (Neu5Gc) degradationpathway: although human is not able to catalyze formation ofNeu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in foodand must be degraded. Also has ManNAc kinase activity.{ECO:0000269|PubMed:22692205}. Converts endogenous N-acetylglucosamine (GlcNAc), amajor component of complex carbohydrates, from lysosomaldegradation or nutritional sources into GlcNAc 6-phosphate.Involved in the N-glycolylneuraminic acid (Neu5Gc) degradationpathway: although human is not able to catalyze formation ofNeu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in foodand must be degraded. Also has ManNAc kinase activity.{ECO:0000269|PubMed:22692205}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAGK_NAGK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAGK_NAGK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAGK_NAGK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAGK_NAGK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAGKC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNAGKC0027627Neoplasm Metastasis1CTD_human
HgeneNAGKC0033578Prostatic Neoplasms1CTD_human
TgeneNAGKC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNAGKC0027627Neoplasm Metastasis1CTD_human
TgeneNAGKC0033578Prostatic Neoplasms1CTD_human