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Fusion gene ID: 23367 |
FusionGeneSummary for NAE1_ENO2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NAE1_ENO2 | Fusion gene ID: 23367 | Hgene | Tgene | Gene symbol | NAE1 | ENO2 | Gene ID | 8883 | 2026 |
Gene name | NEDD8 activating enzyme E1 subunit 1 | enolase 2 | |
Synonyms | A-116A10.1|APPBP1|HPP1|ula-1 | HEL-S-279|NSE | |
Cytomap | 16q22.1 | 12p13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | NEDD8-activating enzyme E1 regulatory subunitAPP-BP1NEDD8-activating enzyme E1 subunitamyloid beta precursor protein binding protein 1, 59kDaamyloid beta precursor protein-binding protein 1, 59 kDaamyloid beta precursor protein-binding protein 1, 59k | gamma-enolase2-phospho-D-glycerate hydro-lyase2-phospho-D-glycerate hydrolyaseenolase 2 (gamma, neuronal)epididymis secretory protein Li 279neural enolaseneuron specific gamma enolaseneuron-specific enolaseneuronal enriched enolaseneurone-specifi | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q13564 | P09104 | |
Ensembl transtripts involved in fusion gene | ENST00000359087, ENST00000290810, ENST00000379463, ENST00000394074, ENST00000564040, | ENST00000541477, ENST00000229277, ENST00000538763, ENST00000544774, ENST00000545045, ENST00000535366, ENST00000534977, | |
Fusion gene scores | * DoF score | 3 X 4 X 1=12 | 3 X 3 X 2=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NAE1 [Title/Abstract] AND ENO2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NAE1 | GO:0033314 | mitotic DNA replication checkpoint | 10722740 |
Hgene | NAE1 | GO:0042981 | regulation of apoptotic process | 14557245 |
Hgene | NAE1 | GO:0043523 | regulation of neuron apoptotic process | 10722740 |
Hgene | NAE1 | GO:0045116 | protein neddylation | 10207026|12740388 |
Hgene | NAE1 | GO:0051402 | neuron apoptotic process | 14557245 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AU142951 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000359087 | ENST00000541477 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000359087 | ENST00000229277 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000359087 | ENST00000538763 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000359087 | ENST00000544774 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000359087 | ENST00000545045 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000359087 | ENST00000535366 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000359087 | ENST00000534977 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000290810 | ENST00000541477 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000290810 | ENST00000229277 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000290810 | ENST00000538763 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000290810 | ENST00000544774 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000290810 | ENST00000545045 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000290810 | ENST00000535366 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000290810 | ENST00000534977 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000379463 | ENST00000541477 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000379463 | ENST00000229277 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000379463 | ENST00000538763 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000379463 | ENST00000544774 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000379463 | ENST00000545045 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000379463 | ENST00000535366 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000379463 | ENST00000534977 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000394074 | ENST00000541477 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000394074 | ENST00000229277 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000394074 | ENST00000538763 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000394074 | ENST00000544774 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000394074 | ENST00000545045 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000394074 | ENST00000535366 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000394074 | ENST00000534977 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000564040 | ENST00000541477 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-5UTR | ENST00000564040 | ENST00000229277 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000564040 | ENST00000538763 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000564040 | ENST00000544774 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000564040 | ENST00000545045 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000564040 | ENST00000535366 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
intron-intron | ENST00000564040 | ENST00000534977 | NAE1 | chr16 | 66842911 | - | ENO2 | chr12 | 7023722 | + |
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FusionProtFeatures for NAE1_ENO2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NAE1 | ENO2 |
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme.E1 activates NEDD8 by first adenylating its C-terminal glycineresidue with ATP, thereafter linking this residue to the sidechain of the catalytic cysteine, yielding a NEDD8-UBA3 thioesterand free AMP. E1 finally transfers NEDD8 to the catalytic cysteineof UBE2M. Necessary for cell cycle progression through the S-Mcheckpoint. Overexpression of NAE1 causes apoptosis throughderegulation of NEDD8 conjugation. {ECO:0000269|PubMed:10207026,ECO:0000269|PubMed:10722740, ECO:0000269|PubMed:12740388}. | Has neurotrophic and neuroprotective properties on abroad spectrum of central nervous system (CNS) neurons. Binds, ina calcium-dependent manner, to cultured neocortical neurons andpromotes cell survival (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NAE1_ENO2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NAE1_ENO2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NAE1_ENO2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NAE1_ENO2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ENO2 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | ENO2 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | ENO2 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Tgene | ENO2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | ENO2 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Tgene | ENO2 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Tgene | ENO2 | C0036341 | Schizophrenia | 1 | PSYGENET |