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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23358

FusionGeneSummary for NADSYN1_KRTAP5-10

check button Fusion gene summary
Fusion gene informationFusion gene name: NADSYN1_KRTAP5-10
Fusion gene ID: 23358
HgeneTgene
Gene symbol

NADSYN1

KRTAP5-10

Gene ID

55191

387273

Gene nameNAD synthetase 1keratin associated protein 5-10
Synonyms-KRTAP5.10
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionglutamine-dependent NAD(+) synthetaseNAD(+) synthaseNAD(+) synthetaseglutamine-dependent NAD synthetasekeratin-associated protein 5-10keratin-associated protein 5.10ultrahigh sulfur keratin-associated protein 5.10
Modification date2018052320180329
UniProtAcc

Q6IA69

Q6L8G5

Ensembl transtripts involved in fusion geneENST00000319023, ENST00000539574, 
ENST00000530055, ENST00000526039, 
ENST00000398531, ENST00000376536, 
Fusion gene scores* DoF score13 X 12 X 8=12481 X 2 X 2=4
# samples 184
** MAII scorelog2(18/1248*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/4*10)=3.32192809488736
Context

PubMed: NADSYN1 [Title/Abstract] AND KRTAP5-10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-66-2759-01ANADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
TCGALDTHYMTCGA-4X-A9FA-01ANADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
TCGALDTHYMTCGA-X7-A8DE-01ANADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
TCGALDTHYMTCGA-XM-AAZ3-01ANADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000319023ENST00000398531NADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
intron-3CDSENST00000319023ENST00000376536NADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
intron-3CDSENST00000539574ENST00000398531NADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
intron-3CDSENST00000539574ENST00000376536NADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
intron-3CDSENST00000530055ENST00000398531NADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
intron-3CDSENST00000530055ENST00000376536NADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
intron-3CDSENST00000526039ENST00000398531NADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
intron-3CDSENST00000526039ENST00000376536NADSYN1chr11

71232250

+KRTAP5-10chr11

71277166

+
intron-3CDSENST00000319023ENST00000398531NADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
intron-3CDSENST00000319023ENST00000376536NADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
intron-3CDSENST00000539574ENST00000398531NADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
intron-3CDSENST00000539574ENST00000376536NADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
intron-3CDSENST00000530055ENST00000398531NADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
intron-3CDSENST00000530055ENST00000376536NADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
intron-3CDSENST00000526039ENST00000398531NADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+
intron-3CDSENST00000526039ENST00000376536NADSYN1chr11

71235153

+KRTAP5-10chr11

71277153

+

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FusionProtFeatures for NADSYN1_KRTAP5-10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NADSYN1

Q6IA69

KRTAP5-10

Q6L8G5

In the hair cortex, hair keratin intermediate filamentsare embedded in an interfilamentous matrix, consisting of hairkeratin-associated protein (KRTAP), which are essential for theformation of a rigid and resistant hair shaft through theirextensive disulfide bond cross-linking with abundant cysteineresidues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NADSYN1_KRTAP5-10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NADSYN1_KRTAP5-10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NADSYN1CUTC, MYO15B, UPF1, AIP, STUB1, EGFR, FKBPL, CSGALNACT2KRTAP5-10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NADSYN1_KRTAP5-10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNADSYN1Q6IA69DB00142Glutamic AcidGlutamine-dependent NAD(+) synthetasesmall moleculeapproved|nutraceutical

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RelatedDiseases for NADSYN1_KRTAP5-10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource