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Fusion gene ID: 23332 |
FusionGeneSummary for NACA2_LSR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NACA2_LSR | Fusion gene ID: 23332 | Hgene | Tgene | Gene symbol | NACA2 | LSR | Gene ID | 342538 | 51599 |
| Gene name | nascent polypeptide associated complex subunit alpha 2 | lipolysis stimulated lipoprotein receptor | |
| Synonyms | ANAC|NACAL | ILDR3|LISCH7 | |
| Cytomap | 17q23.2 | 19q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nascent polypeptide-associated complex subunit alpha-2IgE autoantigen alpha-nascent polypeptide-associated complexalpha-NAC proteinhom s 2.01 proteinnascent polypeptide associated complex alpha subunit 2nascent polypeptide-associated complex, alpha p | lipolysis-stimulated lipoprotein receptorLISCH proteinimmunoglobulin-like domain containing receptor 3lipolysis-stimulated remnantliver-specific bHLH-Zip transcription factor | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9H009 | Q86X29 | |
| Ensembl transtripts involved in fusion gene | ENST00000521764, | ENST00000597933, ENST00000602122, ENST00000361790, ENST00000360798, ENST00000354900, ENST00000347609, ENST00000427250, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NACA2 [Title/Abstract] AND LSR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-1411-01A | NACA2 | chr17 | 59668174 | - | LSR | chr19 | 35757332 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000521764 | ENST00000597933 | NACA2 | chr17 | 59668174 | - | LSR | chr19 | 35757332 | + |
| intron-intron | ENST00000521764 | ENST00000602122 | NACA2 | chr17 | 59668174 | - | LSR | chr19 | 35757332 | + |
| intron-intron | ENST00000521764 | ENST00000361790 | NACA2 | chr17 | 59668174 | - | LSR | chr19 | 35757332 | + |
| intron-intron | ENST00000521764 | ENST00000360798 | NACA2 | chr17 | 59668174 | - | LSR | chr19 | 35757332 | + |
| intron-intron | ENST00000521764 | ENST00000354900 | NACA2 | chr17 | 59668174 | - | LSR | chr19 | 35757332 | + |
| intron-intron | ENST00000521764 | ENST00000347609 | NACA2 | chr17 | 59668174 | - | LSR | chr19 | 35757332 | + |
| intron-intron | ENST00000521764 | ENST00000427250 | NACA2 | chr17 | 59668174 | - | LSR | chr19 | 35757332 | + |
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FusionProtFeatures for NACA2_LSR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NACA2 | LSR |
| Prevents inappropriate targeting of non-secretorypolypeptides to the endoplasmic reticulum (ER). Binds to nascentpolypeptide chains as they emerge from the ribosome and blockstheir interaction with the signal recognition particle (SRP),which normally targets nascent secretory peptides to the ER. Alsoreduces the inherent affinity of ribosomes for proteintranslocation sites in the ER membrane (M sites) (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NACA2_LSR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NACA2_LSR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NACA2 | CDK2, NACA, TUFM, RPL32, RPS13, BTF3, BTF3L4, RPS21, CDH2, VCP, RPL23, RPS25, BCAP29, CALR, CALU, ISYNA1, P4HB, PCNA, PTGES3, RCN1, TPD52 | LSR | SFN, YWHAB, YWHAG, YWHAE, RARG, MAPKAPK5, CCDC8, EGFR, SPINT2, CD1B, NRG1, TMEM231, MCOLN3, TGFBR2, SYNE4, KCNK16, TMEM30A, IL9R, GABRE, PTGER3, TNFRSF10B, HTR3C, MED23, TMEM17, TMEM216, CDH1, STON2, EPS15, RALBP1, EPS15L1, SMAD5, REPS1, ITSN1, PCDHAC2, CLEC2D, AP1B1, AP2A2, ADAM33, ASIC4, VPS45, AP2A1, GPR114, GGT7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NACA2_LSR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NACA2_LSR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LSR | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | LSR | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
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