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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2333

FusionGeneSummary for ARFGAP2_SH3GL2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGAP2_SH3GL2
Fusion gene ID: 2333
HgeneTgene
Gene symbol

ARFGAP2

SH3GL2

Gene ID

84364

6456

Gene nameADP ribosylation factor GTPase activating protein 2SH3 domain containing GRB2 like 2, endophilin A1
SynonymsIRZ|NBLA10535|ZFP289|ZNF289CNSA2|EEN-B1|SH3D2A|SH3P4
Cytomap

11p11.2

9p22.2

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor GTPase-activating protein 2GTPase-activating protein ZNF289zinc finger protein 289, ID1 regulatedendophilin-A1Endophilin A1 BAR domainSH3 domain protein 2ASH3 domain-containing GRB2-like protein 2SH3-domain GRB2-like 2bA335L15.1 (SH3-domain GRB2-like 2)endophilin-1
Modification date2018052320180522
UniProtAcc

Q8N6H7

Q99962

Ensembl transtripts involved in fusion geneENST00000426335, ENST00000524782, 
ENST00000395449, ENST00000319543, 
ENST00000419701, 
ENST00000380607, 
ENST00000467085, ENST00000537391, 
Fusion gene scores* DoF score5 X 5 X 4=1003 X 3 X 2=18
# samples 53
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARFGAP2 [Title/Abstract] AND SH3GL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG987713ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000426335ENST00000380607ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000426335ENST00000467085ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000426335ENST00000537391ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-3UTRENST00000524782ENST00000380607ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000524782ENST00000467085ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000524782ENST00000537391ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-3UTRENST00000395449ENST00000380607ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000395449ENST00000467085ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000395449ENST00000537391ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-3UTRENST00000319543ENST00000380607ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000319543ENST00000467085ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000319543ENST00000537391ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-3UTRENST00000419701ENST00000380607ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000419701ENST00000467085ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-
intron-intronENST00000419701ENST00000537391ARFGAP2chr11

47186135

+SH3GL2chr9

17797070

-

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FusionProtFeatures for ARFGAP2_SH3GL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARFGAP2

Q8N6H7

SH3GL2

Q99962

GTPase-activating protein (GAP) for ADP ribosylationfactor 1 (ARF1). Implicated in coatomer-mediated protein transportbetween the Golgi complex and the endoplasmic reticulum.Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomerfrom Golgi-derived membranes to allow fusion with targetmembranes. {ECO:0000269|PubMed:17760859}. Implicated in synaptic vesicle endocytosis. May recruitother proteins to membranes with high curvature. Required forBDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 tomediate BDNF-NTRK2 early endocytic trafficking and signaling fromearly endosomes. {ECO:0000250|UniProtKB:Q62420}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARFGAP2_SH3GL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARFGAP2_SH3GL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARFGAP2_SH3GL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARFGAP2_SH3GL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARFGAP2C0038356Stomach Neoplasms1CTD_human