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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23315

FusionGeneSummary for NAALADL2_FBXO45

check button Fusion gene summary
Fusion gene informationFusion gene name: NAALADL2_FBXO45
Fusion gene ID: 23315
HgeneTgene
Gene symbol

NAALADL2

FBXO45

Gene ID

254827

200933

Gene nameN-acetylated alpha-linked acidic dipeptidase like 2F-box protein 45
Synonyms-Fbx45
Cytomap

3q26.31

3q29

Type of geneprotein-codingprotein-coding
Descriptioninactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologueF-box/SPRY domain-containing protein 1F-box only protein 45hFbxo45
Modification date2018051920180523
UniProtAcc

Q58DX5

P0C2W1

Ensembl transtripts involved in fusion geneENST00000454872, ENST00000473253, 
ENST00000440469, ENST00000311630, 
Fusion gene scores* DoF score17 X 11 X 8=14961 X 1 X 1=1
# samples 171
** MAII scorelog2(17/1496*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: NAALADL2 [Title/Abstract] AND FBXO45 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFBXO45

GO:0006511

ubiquitin-dependent protein catabolic process

19581926

TgeneFBXO45

GO:0006974

cellular response to DNA damage stimulus

19581926

TgeneFBXO45

GO:0016567

protein ubiquitination

19581926


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A27N-01ANAALADL2chr3

175189546

+FBXO45chr3

196304324

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000454872ENST00000440469NAALADL2chr3

175189546

+FBXO45chr3

196304324

+
5CDS-5UTRENST00000454872ENST00000311630NAALADL2chr3

175189546

+FBXO45chr3

196304324

+
3UTR-5UTRENST00000473253ENST00000440469NAALADL2chr3

175189546

+FBXO45chr3

196304324

+
3UTR-5UTRENST00000473253ENST00000311630NAALADL2chr3

175189546

+FBXO45chr3

196304324

+

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FusionProtFeatures for NAALADL2_FBXO45


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAALADL2

Q58DX5

FBXO45

P0C2W1

May be catalytically inactive. Component of E3 ubiquitin ligase complexes. Required fornormal neuromuscular synaptogenesis, axon pathfinding and neuronalmigration (By similarity). Plays a role in the regulation ofneurotransmission at mature neurons (By similarity). May controlsynaptic activity by controlling UNC13A via ubiquitin dependentpathway (By similarity). Specifically recognizes TP73, promotingits ubiquitination and degradation. {ECO:0000250,ECO:0000269|PubMed:19581926}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAALADL2_FBXO45


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAALADL2_FBXO45


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAALADL2CUL3, APP, GPR25, GRM2, SLC30A3, ITM2B, LAPTM4B, SCAP, KLC2, NAALAD2, KCTD17, IGSF3, ERBB2, KCNJ8, CELSR2, SCARB2, HLA-DRB1FBXO45USP11, TP73, SKP1, MYCBP2, NOS2, PAWR, CDH2, CTNNB1, LGALS3BP, YWHAH, HEY1, HEY2, HEYL, FBXW7, ESR1, CDH19, STAT2, CLEC11A, GDF10, NEURL4, RFC4, GALC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAALADL2_FBXO45


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAALADL2_FBXO45


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFBXO45C0036341Schizophrenia1PSYGENET