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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 23309

FusionGeneSummary for NAALADL2_ABCC5

check button Fusion gene summary
Fusion gene informationFusion gene name: NAALADL2_ABCC5
Fusion gene ID: 23309
HgeneTgene
Gene symbol

NAALADL2

ABCC5

Gene ID

254827

10057

Gene nameN-acetylated alpha-linked acidic dipeptidase like 2ATP binding cassette subfamily C member 5
Synonyms-ABC33|EST277145|MOAT-C|MOATC|MRP5|SMRP|pABC11
Cytomap

3q26.31

3q27.1

Type of geneprotein-codingprotein-coding
Descriptioninactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologuemultidrug resistance-associated protein 5ATP-binding cassette, sub-family C (CFTR/MRP), member 5canalicular multispecific organic anion transporter Cmulti-specific organic anion transporter C
Modification date2018051920180523
UniProtAcc

Q58DX5

O15440

Ensembl transtripts involved in fusion geneENST00000454872, ENST00000473253, 
ENST00000334444, ENST00000265586, 
ENST00000492216, ENST00000427120, 
ENST00000392579, ENST00000382494, 
ENST00000446941, 
Fusion gene scores* DoF score17 X 11 X 8=14966 X 7 X 6=252
# samples 177
** MAII scorelog2(17/1496*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAALADL2 [Title/Abstract] AND ABCC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-33-4538-01ANAALADL2chr3

175345174

+ABCC5chr3

183643507

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000454872ENST00000334444NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
In-frameENST00000454872ENST00000265586NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
5CDS-intronENST00000454872ENST00000492216NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
5CDS-intronENST00000454872ENST00000427120NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
5CDS-intronENST00000454872ENST00000392579NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
5CDS-intronENST00000454872ENST00000382494NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
5CDS-intronENST00000454872ENST00000446941NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
intron-3CDSENST00000473253ENST00000334444NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
intron-3CDSENST00000473253ENST00000265586NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
intron-intronENST00000473253ENST00000492216NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
intron-intronENST00000473253ENST00000427120NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
intron-intronENST00000473253ENST00000392579NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
intron-intronENST00000473253ENST00000382494NAALADL2chr3

175345174

+ABCC5chr3

183643507

-
intron-intronENST00000473253ENST00000446941NAALADL2chr3

175345174

+ABCC5chr3

183643507

-

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FusionProtFeatures for NAALADL2_ABCC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAALADL2

Q58DX5

ABCC5

O15440

May be catalytically inactive.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAALADL2chr3:175345174chr3:183643507ENST00000454872+11141_121632796Topological domainCytoplasmic
HgeneNAALADL2chr3:175345174chr3:183643507ENST00000454872+1114122_142632796TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-071193_1427-39533DomainABC transporter 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07179_459-39533DomainABC transmembrane type-1 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07562_783-39533DomainABC transporter 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07859_1155-39533DomainABC transmembrane type-1 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-061193_1427-39226DomainABC transporter 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06179_459-39226DomainABC transmembrane type-1 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06562_783-39226DomainABC transporter 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06859_1155-39226DomainABC transmembrane type-1 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-071227_1234-39533Nucleotide bindingATP 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07595_602-39533Nucleotide bindingATP 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-061227_1234-39226Nucleotide bindingATP 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06595_602-39226Nucleotide bindingATP 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-071018_1038-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-071104_1124-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-071127_1147-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07179_199-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07219_239-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07296_316-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07317_337-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07400_420-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07434_454-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07608_628-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07848_868-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07917_937-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000382494-07997_1017-39533TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-061018_1038-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-061104_1124-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-061127_1147-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06179_199-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06219_239-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06296_316-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06317_337-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06400_420-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06434_454-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06608_628-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06848_868-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06917_937-39226TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000392579-06997_1017-39226TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAALADL2chr3:175345174chr3:183643507ENST00000454872+1114143_795632796Topological domainExtracellular
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-27301193_142713491438DomainABC transporter 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730179_45913491438DomainABC transmembrane type-1 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730562_78313491438DomainABC transporter 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730859_115513491438DomainABC transmembrane type-1 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-27301227_123413491438Nucleotide bindingATP 2
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730595_60213491438Nucleotide bindingATP 1
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-27301018_103813491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-27301104_112413491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-27301127_114713491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730179_19913491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730219_23913491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730296_31613491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730317_33713491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730400_42013491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730434_45413491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730608_62813491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730848_86813491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730917_93713491438TransmembraneHelical
TgeneABCC5chr3:175345174chr3:183643507ENST00000334444-2730997_101713491438TransmembraneHelical


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FusionGeneSequence for NAALADL2_ABCC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NAALADL2_ENST00000454872_chr3_175345174_+_ABCC5_ENST00000334444_chr3_183643507_-_721aa
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGS
HHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETI
TKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG

>In-frame_NAALADL2_ENST00000454872_chr3_175345174_+_ABCC5_ENST00000265586_chr3_183643507_-_721aa
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGS
HHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETI
TKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NAALADL2_ENST00000454872_chr3_175345174_+_ABCC5_ENST00000334444_chr3_183643507_-_2163nt
ATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGATGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCA
GGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACTTAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGT
TTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAGAGACTATAGACCTCAATCTTGATTCCATTCAACCAGCA
ACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTACCCATTATACACGATCTGCACCAAAGAGCAATCGCTGC
AACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTTTTGGGATTTTGATAGGTTATTATGTACATACAAATTGC
CCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGATTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCT
TTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAAAGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAA
GATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTCCCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTT
CATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAGACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGA
ACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAAAAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATC
GCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGGAAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGAT
CCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGTCACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTAC
CCAAGTGTCGATGAAAGTTTTAGACAAAGCCGATCAAACCTCACCTCTCTATTAGTGCAGCCCATCTCTGCACCCCTCGTTGCAAAACTG
ATCTCTTCGCCAAAAGCTAGAACCAAAAATGAAGCGTGTAGCTCTCTAGAGCTTCCAAATAATGAAATAAGAGTCGTCAGCATGCAAGTT
CAGACAGTCACAAAATTGAAAACAGTTACTAATGTTGTTGGATTTGTAATGGGCTTGACATCTCCAGACCGGTATATCATAGTTGGCAGC
CATCATCACACTGCACACAGTTATAATGGACAAGAATGGGCCAGTAGTACTGCAATAATCACAGCGTTTATCCGTGCCTTGATGTCAAAA
GTTAAGAGAGGGTGGAGACCAGACCGAACTATTGTTTTCTGTTCTTGGGGAGGAACAGCTTTTGGCAATATTGGCTCATATGAATGGGGA
GAGGATTTCAAGAAGGTTCTTCAGAAAAATGTTGTGGCTTATATTAGCCTCCACAGTCCCATAAGGGGGAACTCTAGTCTGTATCCTGTA
GCATCACCATCTCTTCAGCAACTGGTAGTAGAGAAAAATAATTTCAACTGTACCAGAAGAGCCCAGTGCCCAGAAACCAATATCAGTTCT
ATACAGATACAAGGTGATGCTGATTATTTCATCAACCATCTTGGAGTTCCCATCGTGCAGTTTGCTTACGAGGACATCAAAACATTAGAG
GGTCCAAGTTTTCTCTCCGAGGCCCGTTTTTCTACACGAGCAACAAAAATTGAAGAAATGGATCCCTCTTTCAACCTTCATGAAACCATT
ACTAAGATTCTGATTTTAGATGAAGCCACAGCTGCCATGGACACAGAGACAGACTTATTGATTCAAGAGACCATCCGAGAAGCATTTGCA
GACTGTACCATGCTGACCATTGCCCATCGCCTGCACACGGTTCTAGGCTCCGATAGGATTATGGTGCTGGCCCAGGGACAGGTGGTGGAG
TTTGACACCCCATCGGTCCTTCTGTCCAACGACAGTTCCCGATTCTATGCCATGTTTGCTGCTGCAGAGAACAAGGTCGCTGTCAAGGGC

>In-frame_NAALADL2_ENST00000454872_chr3_175345174_+_ABCC5_ENST00000265586_chr3_183643507_-_2163nt
ATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGATGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCA
GGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACTTAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGT
TTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAGAGACTATAGACCTCAATCTTGATTCCATTCAACCAGCA
ACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTACCCATTATACACGATCTGCACCAAAGAGCAATCGCTGC
AACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTTTTGGGATTTTGATAGGTTATTATGTACATACAAATTGC
CCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGATTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCT
TTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAAAGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAA
GATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTCCCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTT
CATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAGACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGA
ACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAAAAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATC
GCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGGAAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGAT
CCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGTCACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTAC
CCAAGTGTCGATGAAAGTTTTAGACAAAGCCGATCAAACCTCACCTCTCTATTAGTGCAGCCCATCTCTGCACCCCTCGTTGCAAAACTG
ATCTCTTCGCCAAAAGCTAGAACCAAAAATGAAGCGTGTAGCTCTCTAGAGCTTCCAAATAATGAAATAAGAGTCGTCAGCATGCAAGTT
CAGACAGTCACAAAATTGAAAACAGTTACTAATGTTGTTGGATTTGTAATGGGCTTGACATCTCCAGACCGGTATATCATAGTTGGCAGC
CATCATCACACTGCACACAGTTATAATGGACAAGAATGGGCCAGTAGTACTGCAATAATCACAGCGTTTATCCGTGCCTTGATGTCAAAA
GTTAAGAGAGGGTGGAGACCAGACCGAACTATTGTTTTCTGTTCTTGGGGAGGAACAGCTTTTGGCAATATTGGCTCATATGAATGGGGA
GAGGATTTCAAGAAGGTTCTTCAGAAAAATGTTGTGGCTTATATTAGCCTCCACAGTCCCATAAGGGGGAACTCTAGTCTGTATCCTGTA
GCATCACCATCTCTTCAGCAACTGGTAGTAGAGAAAAATAATTTCAACTGTACCAGAAGAGCCCAGTGCCCAGAAACCAATATCAGTTCT
ATACAGATACAAGGTGATGCTGATTATTTCATCAACCATCTTGGAGTTCCCATCGTGCAGTTTGCTTACGAGGACATCAAAACATTAGAG
GGTCCAAGTTTTCTCTCCGAGGCCCGTTTTTCTACACGAGCAACAAAAATTGAAGAAATGGATCCCTCTTTCAACCTTCATGAAACCATT
ACTAAGATTCTGATTTTAGATGAAGCCACAGCTGCCATGGACACAGAGACAGACTTATTGATTCAAGAGACCATCCGAGAAGCATTTGCA
GACTGTACCATGCTGACCATTGCCCATCGCCTGCACACGGTTCTAGGCTCCGATAGGATTATGGTGCTGGCCCAGGGACAGGTGGTGGAG
TTTGACACCCCATCGGTCCTTCTGTCCAACGACAGTTCCCGATTCTATGCCATGTTTGCTGCTGCAGAGAACAAGGTCGCTGTCAAGGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NAALADL2_ENST00000454872_chr3_175345174_+_ABCC5_ENST00000334444_chr3_183643507_-_3657nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGA
TGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCAGGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACT
TAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGTTTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAG
AGACTATAGACCTCAATCTTGATTCCATTCAACCAGCAACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTA
CCCATTATACACGATCTGCACCAAAGAGCAATCGCTGCAACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTT
TTGGGATTTTGATAGGTTATTATGTACATACAAATTGCCCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGA
TTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCTTTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAA
AGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTC
CCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAG
ACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAA
AAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGG
AAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGT
CACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGATGAAAGTTTTAGACAAAGCCGATCAAACCTCACCTCTCTAT
TAGTGCAGCCCATCTCTGCACCCCTCGTTGCAAAACTGATCTCTTCGCCAAAAGCTAGAACCAAAAATGAAGCGTGTAGCTCTCTAGAGC
TTCCAAATAATGAAATAAGAGTCGTCAGCATGCAAGTTCAGACAGTCACAAAATTGAAAACAGTTACTAATGTTGTTGGATTTGTAATGG
GCTTGACATCTCCAGACCGGTATATCATAGTTGGCAGCCATCATCACACTGCACACAGTTATAATGGACAAGAATGGGCCAGTAGTACTG
CAATAATCACAGCGTTTATCCGTGCCTTGATGTCAAAAGTTAAGAGAGGGTGGAGACCAGACCGAACTATTGTTTTCTGTTCTTGGGGAG
GAACAGCTTTTGGCAATATTGGCTCATATGAATGGGGAGAGGATTTCAAGAAGGTTCTTCAGAAAAATGTTGTGGCTTATATTAGCCTCC
ACAGTCCCATAAGGGGGAACTCTAGTCTGTATCCTGTAGCATCACCATCTCTTCAGCAACTGGTAGTAGAGAAAAATAATTTCAACTGTA
CCAGAAGAGCCCAGTGCCCAGAAACCAATATCAGTTCTATACAGATACAAGGTGATGCTGATTATTTCATCAACCATCTTGGAGTTCCCA
TCGTGCAGTTTGCTTACGAGGACATCAAAACATTAGAGGGTCCAAGTTTTCTCTCCGAGGCCCGTTTTTCTACACGAGCAACAAAAATTG
AAGAAATGGATCCCTCTTTCAACCTTCATGAAACCATTACTAAGATTCTGATTTTAGATGAAGCCACAGCTGCCATGGACACAGAGACAG
ACTTATTGATTCAAGAGACCATCCGAGAAGCATTTGCAGACTGTACCATGCTGACCATTGCCCATCGCCTGCACACGGTTCTAGGCTCCG
ATAGGATTATGGTGCTGGCCCAGGGACAGGTGGTGGAGTTTGACACCCCATCGGTCCTTCTGTCCAACGACAGTTCCCGATTCTATGCCA
TGTTTGCTGCTGCAGAGAACAAGGTCGCTGTCAAGGGCTGACTCCTCCCTGTTGACGAAGTCTCTTTTCTTTAGAGCATTGCCATTCCCT
GCCTGGGGCGGGCCCCTCATCGCGTCCTCCTACCGAAACCTTGCCTTTCTCGATTTTATCTTTCGCACAGCAGTTCCGGATTGGCTTGTG
TGTTTCACTTTTAGGGAGAGTCATATTTTGATTATTGTATTTATTCCATATTCATGTAAACAAAATTTAGTTTTTGTTCTTAATTGCACT
CTAAAAGGTTCAGGGAACCGTTATTATAATTGTATCAGAGGCCTATAATGAAGCTTTATACGTGTAGCTATATCTATATATAATTCTGTA
CATAGCCTATATTTACAGTGAAAATGTAAGCTGTTTATTTTATATTAAAATAAGCACTGTGCTAATAACAGTGCATATTCCTTTCTATCA
TTTTTGTACAGTTTGCTGTACTAGAGATCTGGTTTTGCTATTAGACTGTAGGAAGAGTAGCATTTCATTCTTCTCTAGCTGGTGGTTTCA
CGGTGCCAGGTTTTCTGGGTGTCCAAAGGAAGACGTGTGGCAATAGTGGGCCCTCCGACAGCCCCCTCTGCCGCCTCCCCACGGCCGCTC
CAGGGGTGGCTGGAGACGGGTGGGCGGCTGGAGACCATGCAGAGCGCCGTGAGTTCTCAGGGCTCCTGCCTTCTGTCCTGGTGTCACTTA
CTGTTTCTGTCAGGAGAGCAGCGGGGCGAAGCCCAGGCCCCTTTTCACTCCCTCCATCAAGAATGGGGATCACAGAGACATTCCTCCGAG
CCGGGGAGTTTCTTTCCTGCCTTCTTCTTTTTGCTGTTGTTTCTAAACAAGAATCAGTCTATCCACAGAGAGTCCCACTGCCTCAGGTTC
CTATGGCTGGCCACTGCACAGAGCTCTCCAGCTCCAAGACCTGTTGGTTCCAAGCCCTGGAGCCAACTGCTGCTTTTTGAGGTGGCACTT
TTTCATTTGCCTATTCCCACACCTCCACAGTTCAGTGGCAGGGCTCAGGATTTCGTGGGTCTGTTTTCCTTTCTCACCGCAGTCGTCGCA
CAGTCTCTCTCTCTCTCTCCCCTCAAAGTCTGCAACTTTAAGCAGCTCTTGCTAATCAGTGTCTCACACTGGCGTAGAAGTTTTTGTACT
GTAAAGAGACCTACCTCAGGTTGCTGGTTGCTGTGTGGTTTGGTGTGTTCCCGCAAACCCCCTTTGTGCTGTGGGGCTGGTAGCTCAGGT
GGGCGTGGTCACTGCTGTCATCAATTGAATGGTCAGCGTTGCATGTCGTGACCAACTAGACATTCTGTCGCCTTAGCATGTTTGCTGAAC

>In-frame_NAALADL2_ENST00000454872_chr3_175345174_+_ABCC5_ENST00000265586_chr3_183643507_-_2377nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGA
TGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCAGGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACT
TAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGTTTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAG
AGACTATAGACCTCAATCTTGATTCCATTCAACCAGCAACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTA
CCCATTATACACGATCTGCACCAAAGAGCAATCGCTGCAACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTT
TTGGGATTTTGATAGGTTATTATGTACATACAAATTGCCCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGA
TTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCTTTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAA
AGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTC
CCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAG
ACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAA
AAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGG
AAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGT
CACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGATGAAAGTTTTAGACAAAGCCGATCAAACCTCACCTCTCTAT
TAGTGCAGCCCATCTCTGCACCCCTCGTTGCAAAACTGATCTCTTCGCCAAAAGCTAGAACCAAAAATGAAGCGTGTAGCTCTCTAGAGC
TTCCAAATAATGAAATAAGAGTCGTCAGCATGCAAGTTCAGACAGTCACAAAATTGAAAACAGTTACTAATGTTGTTGGATTTGTAATGG
GCTTGACATCTCCAGACCGGTATATCATAGTTGGCAGCCATCATCACACTGCACACAGTTATAATGGACAAGAATGGGCCAGTAGTACTG
CAATAATCACAGCGTTTATCCGTGCCTTGATGTCAAAAGTTAAGAGAGGGTGGAGACCAGACCGAACTATTGTTTTCTGTTCTTGGGGAG
GAACAGCTTTTGGCAATATTGGCTCATATGAATGGGGAGAGGATTTCAAGAAGGTTCTTCAGAAAAATGTTGTGGCTTATATTAGCCTCC
ACAGTCCCATAAGGGGGAACTCTAGTCTGTATCCTGTAGCATCACCATCTCTTCAGCAACTGGTAGTAGAGAAAAATAATTTCAACTGTA
CCAGAAGAGCCCAGTGCCCAGAAACCAATATCAGTTCTATACAGATACAAGGTGATGCTGATTATTTCATCAACCATCTTGGAGTTCCCA
TCGTGCAGTTTGCTTACGAGGACATCAAAACATTAGAGGGTCCAAGTTTTCTCTCCGAGGCCCGTTTTTCTACACGAGCAACAAAAATTG
AAGAAATGGATCCCTCTTTCAACCTTCATGAAACCATTACTAAGATTCTGATTTTAGATGAAGCCACAGCTGCCATGGACACAGAGACAG
ACTTATTGATTCAAGAGACCATCCGAGAAGCATTTGCAGACTGTACCATGCTGACCATTGCCCATCGCCTGCACACGGTTCTAGGCTCCG
ATAGGATTATGGTGCTGGCCCAGGGACAGGTGGTGGAGTTTGACACCCCATCGGTCCTTCTGTCCAACGACAGTTCCCGATTCTATGCCA
TGTTTGCTGCTGCAGAGAACAAGGTCGCTGTCAAGGGCTGACTCCTCCCTGTTGACGAAGTCTCTTTTCTTTAGAGCATTGCCATTCCCT


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FusionGenePPI for NAALADL2_ABCC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAALADL2CUL3, APP, GPR25, GRM2, SLC30A3, ITM2B, LAPTM4B, SCAP, KLC2, NAALAD2, KCTD17, IGSF3, ERBB2, KCNJ8, CELSR2, SCARB2, HLA-DRB1ABCC5SMC2, SERPINA3, AK2, RBP5, SHMT2, MOV10, NXF1, TMEM17, NUPL1, TRDN, SCN3B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAALADL2_ABCC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAALADL2_ABCC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCC5C0003873Rheumatoid Arthritis1CTD_human
TgeneABCC5C0009404Colorectal Neoplasms1CTD_human
TgeneABCC5C0023893Liver Cirrhosis, Experimental1CTD_human