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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23303

FusionGeneSummary for NAA60_CLDN9

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA60_CLDN9
Fusion gene ID: 23303
HgeneTgene
Gene symbol

NAA60

CLDN9

Gene ID

79903

9080

Gene nameN(alpha)-acetyltransferase 60, NatF catalytic subunitclaudin 9
SynonymsHAT4|NAT15|NatF|hNaa60-
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 60N-acetyltransferase 15 (GCN5-related, putative)N-alpha-acetyltransferase Fhistone acetyltransferase type B protein 4claudin-9
Modification date2018052320180329
UniProtAcc

Q9H7X0

O95484

Ensembl transtripts involved in fusion geneENST00000576906, ENST00000407558, 
ENST00000608722, ENST00000424546, 
ENST00000573580, ENST00000421765, 
ENST00000610180, ENST00000608993, 
ENST00000360862, ENST00000414063, 
ENST00000570551, ENST00000572942, 
ENST00000576916, ENST00000575076, 
ENST00000577013, ENST00000570819, 
ENST00000572584, 
ENST00000445369, 
Fusion gene scores* DoF score5 X 4 X 4=801 X 1 X 1=1
# samples 51
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: NAA60 [Title/Abstract] AND CLDN9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAA60

GO:0006334

nucleosome assembly

21981917

HgeneNAA60

GO:0006474

N-terminal protein amino acid acetylation

25732826|27320834|27550639

HgeneNAA60

GO:0017196

N-terminal peptidyl-methionine acetylation

21750686

HgeneNAA60

GO:0043967

histone H4 acetylation

21981917


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-CD-8525-01ANAA60chr16

3508181

+CLDN9chr16

3064300

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000576906ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
intron-3UTRENST00000407558ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
intron-3UTRENST00000608722ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
intron-3UTRENST00000424546ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
intron-3UTRENST00000573580ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000421765ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000610180ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000608993ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000360862ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000414063ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
3UTR-3UTRENST00000570551ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000572942ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000576916ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000575076ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000577013ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
5UTR-3UTRENST00000570819ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+
intron-3UTRENST00000572584ENST00000445369NAA60chr16

3508181

+CLDN9chr16

3064300

+

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FusionProtFeatures for NAA60_CLDN9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA60

Q9H7X0

CLDN9

O95484

Plays a major role in tight junction-specificobliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}. (Microbial infection) Acts as a receptor for hepatitis Cvirus (HCV) entry into hepatic cells.{ECO:0000269|PubMed:17804490, ECO:0000269|PubMed:20375010}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAA60_CLDN9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAA60_CLDN9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAA60CLDN9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAA60_CLDN9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAA60_CLDN9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLDN9C0033578Prostatic Neoplasms1CTD_human