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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23293

FusionGeneSummary for NAA38_YLPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA38_YLPM1
Fusion gene ID: 23293
HgeneTgene
Gene symbol

NAA38

YLPM1

Gene ID

84316

56252

Gene nameN(alpha)-acetyltransferase 38, NatC auxiliary subunitYLP motif containing 1
SynonymsLSMD1|PFAAP2C14orf170|PPP1R169|ZAP113|ZAP3
Cytomap

17p13.1

14q24.3

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 38, NatC auxiliary subunitLSM domain containing 1LSM domain-containing protein 1phosphonoformate immuno-associated protein 2YLP motif-containing protein 1nuclear protein ZAP3protein phosphatase 1, regulatory subunit 169
Modification date2018052320180519
UniProtAcc

P49750

Ensembl transtripts involved in fusion geneENST00000249299, ENST00000424702, 
ENST00000422760, 
ENST00000238571, 
ENST00000325680, ENST00000552421, 
ENST00000546901, 
Fusion gene scores* DoF score5 X 4 X 3=609 X 11 X 6=594
# samples 513
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAA38 [Title/Abstract] AND YLPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW274870NAA38chr17

7760355

+YLPM1chr14

75276160

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000249299ENST00000238571NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-3CDSENST00000249299ENST00000325680NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-3CDSENST00000249299ENST00000552421NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-intronENST00000249299ENST00000546901NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-3CDSENST00000424702ENST00000238571NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-3CDSENST00000424702ENST00000325680NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-3CDSENST00000424702ENST00000552421NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-intronENST00000424702ENST00000546901NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-3CDSENST00000422760ENST00000238571NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-3CDSENST00000422760ENST00000325680NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-3CDSENST00000422760ENST00000552421NAA38chr17

7760355

+YLPM1chr14

75276160

-
intron-intronENST00000422760ENST00000546901NAA38chr17

7760355

+YLPM1chr14

75276160

-

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FusionProtFeatures for NAA38_YLPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA38

YLPM1

P49750

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Plays a role in the reduction of telomerase activityduring differentiation of embryonic stem cells by binding to thecore promoter of TERT and controlling its down-regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAA38_YLPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAA38_YLPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAA38_YLPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAA38_YLPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource