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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23288

FusionGeneSummary for NAA35_WDR74

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA35_WDR74
Fusion gene ID: 23288
HgeneTgene
Gene symbol

NAA35

WDR74

Gene ID

60560

54663

Gene nameN(alpha)-acetyltransferase 35, NatC auxiliary subunitWD repeat domain 74
SynonymsEGAP|MAK10|MAK10P|bA379P1.1-
Cytomap

9q21.33

11q12.3

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 35, NatC auxiliary subunitMAK10 homolog, amino-acid N-acetyltransferase subunitcorneal wound healing-related proteinembryonic growth-associated protein homologprotein MAK10 homologWD repeat-containing protein 74NOP seven-associated protein 1
Modification date2018052320180523
UniProtAcc

Q5VZE5

Q6RFH5

Ensembl transtripts involved in fusion geneENST00000361671, ENST00000376040, 
ENST00000311713, ENST00000278856, 
ENST00000529106, ENST00000525239, 
ENST00000525752, ENST00000540620, 
Fusion gene scores* DoF score4 X 3 X 4=485 X 4 X 6=120
# samples 48
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAA35 [Title/Abstract] AND WDR74 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-GI-A2C9-01ANAA35chr9

88577095

+WDR74chr11

62600603

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361671ENST00000311713NAA35chr9

88577095

+WDR74chr11

62600603

-
Frame-shiftENST00000361671ENST00000278856NAA35chr9

88577095

+WDR74chr11

62600603

-
Frame-shiftENST00000361671ENST00000529106NAA35chr9

88577095

+WDR74chr11

62600603

-
Frame-shiftENST00000361671ENST00000525239NAA35chr9

88577095

+WDR74chr11

62600603

-
Frame-shiftENST00000361671ENST00000525752NAA35chr9

88577095

+WDR74chr11

62600603

-
5CDS-intronENST00000361671ENST00000540620NAA35chr9

88577095

+WDR74chr11

62600603

-
In-frameENST00000376040ENST00000311713NAA35chr9

88577095

+WDR74chr11

62600603

-
Frame-shiftENST00000376040ENST00000278856NAA35chr9

88577095

+WDR74chr11

62600603

-
Frame-shiftENST00000376040ENST00000529106NAA35chr9

88577095

+WDR74chr11

62600603

-
Frame-shiftENST00000376040ENST00000525239NAA35chr9

88577095

+WDR74chr11

62600603

-
Frame-shiftENST00000376040ENST00000525752NAA35chr9

88577095

+WDR74chr11

62600603

-
5CDS-intronENST00000376040ENST00000540620NAA35chr9

88577095

+WDR74chr11

62600603

-

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FusionProtFeatures for NAA35_WDR74


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA35

Q5VZE5

WDR74

Q6RFH5

Auxillary component of the N-terminal acetyltransferaseC (NatC) complex which catalyzes acetylation of N-terminalmethionine residues. Involved in regulation of apoptosis andproliferation of smooth muscle cells.{ECO:0000269|PubMed:19398576}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR74chr9:88577095chr11:62600603ENST00000278856-911128_168326386RepeatNote=WD 3
TgeneWDR74chr9:88577095chr11:62600603ENST00000278856-911179_220326386RepeatNote=WD 4
TgeneWDR74chr9:88577095chr11:62600603ENST00000278856-911224_266326386RepeatNote=WD 5
TgeneWDR74chr9:88577095chr11:62600603ENST00000278856-911267_306326386RepeatNote=WD 6
TgeneWDR74chr9:88577095chr11:62600603ENST00000278856-91140_80326386RepeatNote=WD 1
TgeneWDR74chr9:88577095chr11:62600603ENST00000278856-91183_122326386RepeatNote=WD 2
TgeneWDR74chr9:88577095chr11:62600603ENST00000311713-810128_168307367RepeatNote=WD 3
TgeneWDR74chr9:88577095chr11:62600603ENST00000311713-810179_220307367RepeatNote=WD 4
TgeneWDR74chr9:88577095chr11:62600603ENST00000311713-810224_266307367RepeatNote=WD 5
TgeneWDR74chr9:88577095chr11:62600603ENST00000311713-810267_306307367RepeatNote=WD 6
TgeneWDR74chr9:88577095chr11:62600603ENST00000311713-81040_80307367RepeatNote=WD 1
TgeneWDR74chr9:88577095chr11:62600603ENST00000311713-81083_122307367RepeatNote=WD 2
TgeneWDR74chr9:88577095chr11:62600603ENST00000525239-1012128_168326386RepeatNote=WD 3
TgeneWDR74chr9:88577095chr11:62600603ENST00000525239-1012179_220326386RepeatNote=WD 4
TgeneWDR74chr9:88577095chr11:62600603ENST00000525239-1012224_266326386RepeatNote=WD 5
TgeneWDR74chr9:88577095chr11:62600603ENST00000525239-1012267_306326386RepeatNote=WD 6
TgeneWDR74chr9:88577095chr11:62600603ENST00000525239-101240_80326386RepeatNote=WD 1
TgeneWDR74chr9:88577095chr11:62600603ENST00000525239-101283_122326386RepeatNote=WD 2
TgeneWDR74chr9:88577095chr11:62600603ENST00000529106-1012128_168326386RepeatNote=WD 3
TgeneWDR74chr9:88577095chr11:62600603ENST00000529106-1012179_220326386RepeatNote=WD 4
TgeneWDR74chr9:88577095chr11:62600603ENST00000529106-1012224_266326386RepeatNote=WD 5
TgeneWDR74chr9:88577095chr11:62600603ENST00000529106-1012267_306326386RepeatNote=WD 6
TgeneWDR74chr9:88577095chr11:62600603ENST00000529106-101240_80326386RepeatNote=WD 1
TgeneWDR74chr9:88577095chr11:62600603ENST00000529106-101283_122326386RepeatNote=WD 2


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FusionGeneSequence for NAA35_WDR74


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NAA35_ENST00000361671_chr9_88577095_+_WDR74_ENST00000311713_chr11_62600603_-_232aa
MVMKASVDDDDSGWELSMPEKMEKSNTNWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAI
KDGTIKIKDLTLPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEDEPQEPQE

>In-frame_NAA35_ENST00000376040_chr9_88577095_+_WDR74_ENST00000311713_chr11_62600603_-_232aa
MVMKASVDDDDSGWELSMPEKMEKSNTNWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAI
KDGTIKIKDLTLPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEDEPQEPQE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NAA35_ENST00000361671_chr9_88577095_+_WDR74_ENST00000311713_chr11_62600603_-_696nt
ATGGTTATGAAAGCTTCTGTAGATGATGACGATTCAGGATGGGAGCTCAGTATGCCAGAAAAAATGGAGAAAAGCAATACAAACTGGGTG
GACATTACCCAAGATTTTGAAGAAGCTTGTCGAGAATTAAAGTTGGGAGAACTACTTCATGATAAGCTATTTGGTCTTTTTGAAGCCATG
TCTGCTATTGAAATGATGGATCCCAAGATGGATGCTGGCATGATTGGAAACCAAGTTAATCGAAAAGTTCTCAATTTTGAACAAGCTATC
AAGGATGGCACTATTAAAATTAAAGATCTCACCTTGCCTGAACTGATAGGGATTATGGATACATGTTTTTGCTGTTTGATAACGTGGTTA
GAAGGCCATTCACTGGCACAGACAGTATTTACGTGCCTTTACATTCATAATCCAGACTTTATAGAAGATCCTGCTATGAAGGCTTTTGCT
CTGGGAATCTTGAAAATCTGTGACATTGCAAGGGAAAAAGTAAATAAAGCTGCTGTTTTTGAAGAGGATGAGCCCCAAGAGCCTCAAGAA
CCCAACAAGGTGCCCCTAGAAGACACAGAGACAGATGAACTTTGGGCATCCTTGGAGGCAGCTGCCAAGCGGAAGCTCTCGGGTTTGGAG

>In-frame_NAA35_ENST00000376040_chr9_88577095_+_WDR74_ENST00000311713_chr11_62600603_-_696nt
ATGGTTATGAAAGCTTCTGTAGATGATGACGATTCAGGATGGGAGCTCAGTATGCCAGAAAAAATGGAGAAAAGCAATACAAACTGGGTG
GACATTACCCAAGATTTTGAAGAAGCTTGTCGAGAATTAAAGTTGGGAGAACTACTTCATGATAAGCTATTTGGTCTTTTTGAAGCCATG
TCTGCTATTGAAATGATGGATCCCAAGATGGATGCTGGCATGATTGGAAACCAAGTTAATCGAAAAGTTCTCAATTTTGAACAAGCTATC
AAGGATGGCACTATTAAAATTAAAGATCTCACCTTGCCTGAACTGATAGGGATTATGGATACATGTTTTTGCTGTTTGATAACGTGGTTA
GAAGGCCATTCACTGGCACAGACAGTATTTACGTGCCTTTACATTCATAATCCAGACTTTATAGAAGATCCTGCTATGAAGGCTTTTGCT
CTGGGAATCTTGAAAATCTGTGACATTGCAAGGGAAAAAGTAAATAAAGCTGCTGTTTTTGAAGAGGATGAGCCCCAAGAGCCTCAAGAA
CCCAACAAGGTGCCCCTAGAAGACACAGAGACAGATGAACTTTGGGCATCCTTGGAGGCAGCTGCCAAGCGGAAGCTCTCGGGTTTGGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NAA35_ENST00000361671_chr9_88577095_+_WDR74_ENST00000311713_chr11_62600603_-_870nt
ATACGCATGCGTGCACGCTGCCGGTCGGGCTGGGCTGAGAGGGGAGGGGGCGGCGGCGGCCGAGGCGGCGTCGTTATTTCCGTGGTCCGG
ACAGTGCGTGGCGGCGCGGGTGACCACGGGAGAAGTAGGCATAATGGTTATGAAAGCTTCTGTAGATGATGACGATTCAGGATGGGAGCT
CAGTATGCCAGAAAAAATGGAGAAAAGCAATACAAACTGGGTGGACATTACCCAAGATTTTGAAGAAGCTTGTCGAGAATTAAAGTTGGG
AGAACTACTTCATGATAAGCTATTTGGTCTTTTTGAAGCCATGTCTGCTATTGAAATGATGGATCCCAAGATGGATGCTGGCATGATTGG
AAACCAAGTTAATCGAAAAGTTCTCAATTTTGAACAAGCTATCAAGGATGGCACTATTAAAATTAAAGATCTCACCTTGCCTGAACTGAT
AGGGATTATGGATACATGTTTTTGCTGTTTGATAACGTGGTTAGAAGGCCATTCACTGGCACAGACAGTATTTACGTGCCTTTACATTCA
TAATCCAGACTTTATAGAAGATCCTGCTATGAAGGCTTTTGCTCTGGGAATCTTGAAAATCTGTGACATTGCAAGGGAAAAAGTAAATAA
AGCTGCTGTTTTTGAAGAGGATGAGCCCCAAGAGCCTCAAGAACCCAACAAGGTGCCCCTAGAAGACACAGAGACAGATGAACTTTGGGC
ATCCTTGGAGGCAGCTGCCAAGCGGAAGCTCTCGGGTTTGGAGCAGCCCCAAGGAGCTCTCCAAACGAGACGGAGAAAGAAGAAGCGGCC

>In-frame_NAA35_ENST00000376040_chr9_88577095_+_WDR74_ENST00000311713_chr11_62600603_-_1088nt
GCTTATGCGCCCAGTGGGACCGGGGCTGGGCTGGGCTGACCCGGGCAGGGCGGAAGGGAAGCGTGTGCCCGCCTCAGGTGTGCCTCGGCC
CTAGGCCCGGCCGGCGGGACCCTGCGGTGCCTGCCGGCTCCTCATTGCTCCCGGCGAGGTTCTGCCTGGGTCCGGGCCGGCTCTGGCCCG
GGAGAGGTCCCAGCGAGCTCTGGCCAGATGAAGGGCTACCTTGATTGACTTCGGTAGCTGCCGCATGGGGTCCTGGGCTGCGAGAGGGGA
CCCTGAATAGTGCCTTGGTCTTTTGTGGCTATTATTGAAAGTTGGAAGCTCTGGAGTTGTTCTTTTCGGGCCAGAGGCATAATGGTTATG
AAAGCTTCTGTAGATGATGACGATTCAGGATGGGAGCTCAGTATGCCAGAAAAAATGGAGAAAAGCAATACAAACTGGGTGGACATTACC
CAAGATTTTGAAGAAGCTTGTCGAGAATTAAAGTTGGGAGAACTACTTCATGATAAGCTATTTGGTCTTTTTGAAGCCATGTCTGCTATT
GAAATGATGGATCCCAAGATGGATGCTGGCATGATTGGAAACCAAGTTAATCGAAAAGTTCTCAATTTTGAACAAGCTATCAAGGATGGC
ACTATTAAAATTAAAGATCTCACCTTGCCTGAACTGATAGGGATTATGGATACATGTTTTTGCTGTTTGATAACGTGGTTAGAAGGCCAT
TCACTGGCACAGACAGTATTTACGTGCCTTTACATTCATAATCCAGACTTTATAGAAGATCCTGCTATGAAGGCTTTTGCTCTGGGAATC
TTGAAAATCTGTGACATTGCAAGGGAAAAAGTAAATAAAGCTGCTGTTTTTGAAGAGGATGAGCCCCAAGAGCCTCAAGAACCCAACAAG
GTGCCCCTAGAAGACACAGAGACAGATGAACTTTGGGCATCCTTGGAGGCAGCTGCCAAGCGGAAGCTCTCGGGTTTGGAGCAGCCCCAA
GGAGCTCTCCAAACGAGACGGAGAAAGAAGAAGCGGCCTGGGTCCACCAGCCCCTGACGCCCCTGTGCCCACTTTGTAAATAAACTGCTG


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FusionGenePPI for NAA35_WDR74


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAA35FGL1, ANKZF1, NTRK1, DUSP19, CD2BP2WDR74RGS2, NUDT3, DDX39B, USP7, UBE3C, PUS7, WBSCR22, PPIP5K2, NSUN2, VAT1, HDAC11, RCHY1, CARD8, CCNJL, DDX47, DHX37, GNL2, RRS1, SSB, ZC3H15, IFI16, XPO1, PDGFRA, PKN2, THOC5, NOP56, IBTK, C17orf85, BOP1, MAK16, RPF1, RBM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAA35_WDR74


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAA35_WDR74


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWDR74C0025202melanoma1CTD_human