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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23267

FusionGeneSummary for NAA10_ZDHHC16

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA10_ZDHHC16
Fusion gene ID: 23267
HgeneTgene
Gene symbol

NAA10

ZDHHC16

Gene ID

8260

84287

Gene nameN(alpha)-acetyltransferase 10, NatA catalytic subunitzinc finger DHHC-type containing 16
SynonymsARD1|ARD1A|ARD1P|DXS707|MCOPS1|NATD|OGDNS|TE2|hARD1APH2|DHHC-16
Cytomap

Xq28

10q24.1

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 10ARD1 homolog A, N-acetyltransferaseN-acetyltransferase ARD1, human homolog ofN-terminal acetyltransferase complex ARD1 subunit homolog AnatA catalytic subunit Naa10palmitoyltransferase ZDHHC16Abl-philin 2probable palmitoyltransferase ZDHHC16zinc finger DHHC domain-containing protein 16zinc finger, DHHC domain containing 16
Modification date2018052320180523
UniProtAcc

P41227

Q969W1

Ensembl transtripts involved in fusion geneENST00000464845, ENST00000370015, 
ENST00000393712, ENST00000370009, 
ENST00000393710, 
ENST00000370854, 
ENST00000393760, ENST00000370846, 
ENST00000352634, ENST00000353979, 
ENST00000370842, ENST00000345745, 
ENST00000495735, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 4=100
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAA10 [Title/Abstract] AND ZDHHC16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAA10

GO:0006473

protein acetylation

27708256

HgeneNAA10

GO:0006474

N-terminal protein amino acid acetylation

15496142|19480662|25489052

HgeneNAA10

GO:2000719

negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric

27422821

TgeneZDHHC16

GO:0018345

protein palmitoylation

23034182|28826475


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF916762NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000464845ENST00000370854NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000464845ENST00000393760NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000464845ENST00000370846NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000464845ENST00000352634NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000464845ENST00000353979NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000464845ENST00000370842NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000464845ENST00000345745NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3UTRENST00000464845ENST00000495735NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000370015ENST00000370854NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000370015ENST00000393760NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370015ENST00000370846NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370015ENST00000352634NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370015ENST00000353979NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370015ENST00000370842NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370015ENST00000345745NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3UTRENST00000370015ENST00000495735NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000393712ENST00000370854NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000393712ENST00000393760NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393712ENST00000370846NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393712ENST00000352634NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393712ENST00000353979NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393712ENST00000370842NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393712ENST00000345745NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3UTRENST00000393712ENST00000495735NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000370009ENST00000370854NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000370009ENST00000393760NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370009ENST00000370846NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370009ENST00000352634NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370009ENST00000353979NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370009ENST00000370842NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000370009ENST00000345745NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3UTRENST00000370009ENST00000495735NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000393710ENST00000370854NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3CDSENST00000393710ENST00000393760NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393710ENST00000370846NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393710ENST00000352634NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393710ENST00000353979NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393710ENST00000370842NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-intronENST00000393710ENST00000345745NAA10chrX

153196224

-ZDHHC16chr10

99213322

-
intron-3UTRENST00000393710ENST00000495735NAA10chrX

153196224

-ZDHHC16chr10

99213322

-

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FusionProtFeatures for NAA10_ZDHHC16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA10

P41227

ZDHHC16

Q969W1

Catalytic subunit of the N-terminal acetyltransferase A(NatA) complex which displays alpha (N-terminal) acetyltransferaseactivity (PubMed:15496142, PubMed:19826488, PubMed:19420222,PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylatesamino termini that are devoid of initiator methionine(PubMed:19420222). The alpha (N-terminal) acetyltransferaseactivity may be important for vascular, hematopoietic and neuronalgrowth and development. Without NAA15, displays epsilon (internal)acetyltransferase activity towards HIF1A, thereby promoting itsdegradation (PubMed:12464182). Represses MYLK kinase activity byacetylation, and thus represses tumor cell migration(PubMed:19826488). Acetylates, and stabilizes TSC2, therebyrepressing mTOR activity and suppressing cancer development(PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' whichenhances its chaperone activity and leads to preferential bindingto co-chaperone HOPX (PubMed:27708256). Acts as a negativeregulator of sister chromatid cohesion during mitosis(PubMed:27422821). {ECO:0000269|PubMed:12464182,ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222,ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209,ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821,ECO:0000269|PubMed:27708256}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAA10_ZDHHC16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAA10_ZDHHC16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAA10_ZDHHC16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAA10_ZDHHC16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAA10C3275447OGDEN SYNDROME2ORPHANET;UNIPROT