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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23265

FusionGeneSummary for NAA10_CD44

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA10_CD44
Fusion gene ID: 23265
HgeneTgene
Gene symbol

NAA10

CD44

Gene ID

8260

960

Gene nameN(alpha)-acetyltransferase 10, NatA catalytic subunitCD44 molecule (Indian blood group)
SynonymsARD1|ARD1A|ARD1P|DXS707|MCOPS1|NATD|OGDNS|TE2|hARD1CDW44|CSPG8|ECMR-III|HCELL|HUTCH-I|IN|LHR|MC56|MDU2|MDU3|MIC4|Pgp1
Cytomap

Xq28

11p13

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 10ARD1 homolog A, N-acetyltransferaseN-acetyltransferase ARD1, human homolog ofN-terminal acetyltransferase complex ARD1 subunit homolog AnatA catalytic subunit Naa10CD44 antigenGP90 lymphocyte homing/adhesion receptorHermes antigencell surface glycoprotein CD44chondroitin sulfate proteoglycan 8epicanextracellular matrix receptor IIIhematopoietic cell E- and L-selectin ligandheparan sulfate proteoglycanhoming
Modification date2018052320180527
UniProtAcc

P41227

P16070

Ensembl transtripts involved in fusion geneENST00000464845, ENST00000370015, 
ENST00000393712, ENST00000370009, 
ENST00000393710, 		ENST00000263398, 
ENST00000526025, ENST00000449691, 
ENST00000360158, ENST00000415148, 
ENST00000437706, ENST00000433354, 
ENST00000428726, ENST00000526669, 
ENST00000433892, ENST00000278386, 
ENST00000434472, ENST00000352818, 
ENST00000528922, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 7 X 3=126
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAA10 [Title/Abstract] AND CD44 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAA10

GO:0006473

protein acetylation

27708256

HgeneNAA10

GO:0006474

N-terminal protein amino acid acetylation

15496142|19480662|25489052

HgeneNAA10

GO:2000719

negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric

27422821

TgeneCD44

GO:0030214

hyaluronan catabolic process

17170110

TgeneCD44

GO:0033138

positive regulation of peptidyl-serine phosphorylation

17045821

TgeneCD44

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

TgeneCD44

GO:0044344

cellular response to fibroblast growth factor stimulus

19577615

TgeneCD44

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

TgeneCD44

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821

TgeneCD44

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17045821


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP270776NAA10chrX

153197866

-CD44chr11

35251215

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000464845ENST00000263398NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000526025NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000449691NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000360158NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000415148NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000437706NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000433354NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000464845ENST00000428726NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000526669NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000464845ENST00000433892NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000278386NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000434472NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000352818NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000464845ENST00000528922NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000370015ENST00000263398NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000526025NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000449691NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000360158NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000415148NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000437706NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000433354NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000370015ENST00000428726NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000526669NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000370015ENST00000433892NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000278386NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000434472NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000352818NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370015ENST00000528922NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000393712ENST00000263398NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000526025NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000449691NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000360158NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000415148NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000437706NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000433354NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000393712ENST00000428726NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000526669NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000393712ENST00000433892NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000278386NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000434472NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000352818NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393712ENST00000528922NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000370009ENST00000263398NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000526025NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000449691NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000360158NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000415148NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000437706NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000433354NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000370009ENST00000428726NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000526669NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000370009ENST00000433892NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000278386NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000434472NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000352818NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000370009ENST00000528922NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000393710ENST00000263398NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000526025NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000449691NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000360158NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000415148NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000437706NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000433354NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000393710ENST00000428726NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000526669NAA10chrX

153197866

-CD44chr11

35251215

+
intron-3UTRENST00000393710ENST00000433892NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000278386NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000434472NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000352818NAA10chrX

153197866

-CD44chr11

35251215

+
intron-intronENST00000393710ENST00000528922NAA10chrX

153197866

-CD44chr11

35251215

+

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FusionProtFeatures for NAA10_CD44


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA10

P41227

CD44

P16070

Catalytic subunit of the N-terminal acetyltransferase A(NatA) complex which displays alpha (N-terminal) acetyltransferaseactivity (PubMed:15496142, PubMed:19826488, PubMed:19420222,PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylatesamino termini that are devoid of initiator methionine(PubMed:19420222). The alpha (N-terminal) acetyltransferaseactivity may be important for vascular, hematopoietic and neuronalgrowth and development. Without NAA15, displays epsilon (internal)acetyltransferase activity towards HIF1A, thereby promoting itsdegradation (PubMed:12464182). Represses MYLK kinase activity byacetylation, and thus represses tumor cell migration(PubMed:19826488). Acetylates, and stabilizes TSC2, therebyrepressing mTOR activity and suppressing cancer development(PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' whichenhances its chaperone activity and leads to preferential bindingto co-chaperone HOPX (PubMed:27708256). Acts as a negativeregulator of sister chromatid cohesion during mitosis(PubMed:27422821). {ECO:0000269|PubMed:12464182,ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222,ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209,ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821,ECO:0000269|PubMed:27708256}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NAA10_CD44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NAA10_CD44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NAA10_CD44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCD44P16070DB08818Hyaluronic acidCD44 antigensmall moleculeapproved|vet_approved

Top

RelatedDiseases for NAA10_CD44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAA10C3275447OGDEN SYNDROME2ORPHANET;UNIPROT
TgeneCD44C0023487Acute Promyelocytic Leukemia2CTD_human
TgeneCD44C0011616Contact Dermatitis1CTD_human
TgeneCD44C0017661IGA Glomerulonephritis1CTD_human
TgeneCD44C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneCD44C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneCD44C0027627Neoplasm Metastasis1CTD_human
TgeneCD44C0027746Nerve Degeneration1CTD_human
TgeneCD44C0030297Pancreatic Neoplasm1CTD_human
TgeneCD44C0037274Dermatologic disorders1CTD_human
TgeneCD44C0038356Stomach Neoplasms1CTD_human
TgeneCD44C0042900Vitiligo1CTD_human
TgeneCD44C0311375Arsenic Poisoning1CTD_human
TgeneCD44C2609414Acute kidney injury1CTD_human