FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23259

FusionGeneSummary for N4BP2L2_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: N4BP2L2_MBP
Fusion gene ID: 23259
HgeneTgene
Gene symbol

N4BP2L2

MBP

Gene ID

10443

5553

Gene nameNEDD4 binding protein 2 like 2proteoglycan 2, pro eosinophil major basic protein
Synonyms92M18.3|CG005|CG016|PFAAP5BMPG|MBP|MBP1|proMBP
Cytomap

13q13.1

11q12.1

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 regionbone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018051920180519
UniProtAcc

Q92802

P02686

Ensembl transtripts involved in fusion geneENST00000380121, ENST00000504114, 
ENST00000357505, ENST00000399396, 
ENST00000446957, ENST00000267068, 
ENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
Fusion gene scores* DoF score7 X 8 X 4=22426 X 20 X 3=1560
# samples 2027
** MAII scorelog2(20/224*10)=-0.163498732282879
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: N4BP2L2 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK125067N4BP2L2chr13

33006968

-MBPchr18

74691001

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000380121ENST00000382582N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000380121ENST00000355994N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000380121ENST00000397875N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000380121ENST00000397866N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000380121ENST00000397865N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000527041N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000359645N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000528160N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000397869N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000354542N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000526111N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000580402N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000579129N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000578193N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000397863N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000397860N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000380121ENST00000487778N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000504114ENST00000382582N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000504114ENST00000355994N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000504114ENST00000397875N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000504114ENST00000397866N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000504114ENST00000397865N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000527041N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000359645N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000528160N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000397869N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000354542N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000526111N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000580402N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000579129N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000578193N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000397863N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000397860N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000504114ENST00000487778N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000357505ENST00000382582N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000357505ENST00000355994N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000357505ENST00000397875N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000357505ENST00000397866N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000357505ENST00000397865N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000527041N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000359645N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000528160N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000397869N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000354542N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000526111N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000580402N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000579129N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000578193N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000397863N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000397860N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000357505ENST00000487778N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000399396ENST00000382582N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000399396ENST00000355994N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000399396ENST00000397875N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000399396ENST00000397866N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000399396ENST00000397865N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000527041N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000359645N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000528160N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000397869N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000354542N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000526111N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000580402N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000579129N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000578193N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000397863N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000397860N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000399396ENST00000487778N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000446957ENST00000382582N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000446957ENST00000355994N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000446957ENST00000397875N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000446957ENST00000397866N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000446957ENST00000397865N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000527041N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000359645N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000528160N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000397869N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000354542N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000526111N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000580402N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000579129N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000578193N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000397863N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000397860N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000446957ENST00000487778N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000267068ENST00000382582N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000267068ENST00000355994N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000267068ENST00000397875N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000267068ENST00000397866N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-3UTRENST00000267068ENST00000397865N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000527041N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000359645N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000528160N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000397869N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000354542N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000526111N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000580402N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000579129N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000578193N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000397863N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000397860N4BP2L2chr13

33006968

-MBPchr18

74691001

-
intron-intronENST00000267068ENST00000487778N4BP2L2chr13

33006968

-MBPchr18

74691001

-

Top

FusionProtFeatures for N4BP2L2_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
N4BP2L2

Q92802

MBP

P02686


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for N4BP2L2_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for N4BP2L2_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for N4BP2L2_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for N4BP2L2_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneN4BP2L2C0037274Dermatologic disorders1CTD_human
HgeneN4BP2L2C0311375Arsenic Poisoning1CTD_human
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human