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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23253

FusionGeneSummary for N4BP1_N4BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: N4BP1_N4BP1
Fusion gene ID: 23253
HgeneTgene
Gene symbol

N4BP1

N4BP1

Gene ID

9683

9683

Gene nameNEDD4 binding protein 1NEDD4 binding protein 1
Synonyms--
Cytomap

16q12.1

16q12.1

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-binding protein 1NEDD4-binding protein 1
Modification date2018052220180522
UniProtAcc

O75113

O75113

Ensembl transtripts involved in fusion geneENST00000262384, ENST00000565423, 
ENST00000262384, ENST00000565423, 
Fusion gene scores* DoF score7 X 5 X 4=1402 X 2 X 2=8
# samples 95
** MAII scorelog2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/8*10)=2.64385618977472
Context

PubMed: N4BP1 [Title/Abstract] AND N4BP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA827624N4BP1chr16

48595261

-N4BP1chr16

48595799

-
ChiTaRS3.1AA906470N4BP1chr16

48595261

-N4BP1chr16

48595799

-
ChiTaRS3.1AW663512N4BP1chr16

48595261

-N4BP1chr16

48595799

-
ChiTaRS3.1AW014162N4BP1chr16

48595261

-N4BP1chr16

48595799

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000262384ENST00000262384N4BP1chr16

48595261

-N4BP1chr16

48595799

-
intron-intronENST00000262384ENST00000565423N4BP1chr16

48595261

-N4BP1chr16

48595799

-
intron-3CDSENST00000565423ENST00000262384N4BP1chr16

48595261

-N4BP1chr16

48595799

-
intron-intronENST00000565423ENST00000565423N4BP1chr16

48595261

-N4BP1chr16

48595799

-

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FusionProtFeatures for N4BP1_N4BP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
N4BP1

O75113

N4BP1

O75113

Inhibitor of the E3 ubiquitin-protein ligase ITCH. Actsby interacting with the second WW domain of ITCH, leading tocompete with ITCH's substrates and impairing ubiquitination ofsubstrates (By similarity). {ECO:0000250}. Inhibitor of the E3 ubiquitin-protein ligase ITCH. Actsby interacting with the second WW domain of ITCH, leading tocompete with ITCH's substrates and impairing ubiquitination ofsubstrates (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for N4BP1_N4BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for N4BP1_N4BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for N4BP1_N4BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for N4BP1_N4BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource