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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2325

FusionGeneSummary for ARF3_WNT10B

check button Fusion gene summary
Fusion gene informationFusion gene name: ARF3_WNT10B
Fusion gene ID: 2325
HgeneTgene
Gene symbol

ARF3

WNT10B

Gene ID

377

7480

Gene nameADP ribosylation factor 3Wnt family member 10B
Synonyms-SHFM6|STHAG8|WNT-12
Cytomap

12q13.12

12q13.12

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor 3small GTP binding proteinprotein Wnt-10bWNT-10B proteinwingless-type MMTV integration site family, member 10B
Modification date2018052320180527
UniProtAcc

P61204

O00744

Ensembl transtripts involved in fusion geneENST00000256682, ENST00000447318, 
ENST00000541959, ENST00000541967, 
ENST00000301061, ENST00000407467, 
ENST00000403957, 
Fusion gene scores* DoF score7 X 8 X 3=1681 X 1 X 1=1
# samples 91
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ARF3 [Title/Abstract] AND WNT10B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWNT10B

GO:0045599

negative regulation of fat cell differentiation

10937998

TgeneWNT10B

GO:0050821

protein stabilization

10937998

TgeneWNT10B

GO:0060070

canonical Wnt signaling pathway

17761539

TgeneWNT10B

GO:0071425

hematopoietic stem cell proliferation

9787155


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-HV-A5A5-01AARF3chr12

49351093

-WNT10Bchr12

49364352

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000256682ENST00000301061ARF3chr12

49351093

-WNT10Bchr12

49364352

-
5UTR-5UTRENST00000256682ENST00000407467ARF3chr12

49351093

-WNT10Bchr12

49364352

-
5UTR-5UTRENST00000256682ENST00000403957ARF3chr12

49351093

-WNT10Bchr12

49364352

-
5UTR-5UTRENST00000447318ENST00000301061ARF3chr12

49351093

-WNT10Bchr12

49364352

-
5UTR-5UTRENST00000447318ENST00000407467ARF3chr12

49351093

-WNT10Bchr12

49364352

-
5UTR-5UTRENST00000447318ENST00000403957ARF3chr12

49351093

-WNT10Bchr12

49364352

-
5UTR-5UTRENST00000541959ENST00000301061ARF3chr12

49351093

-WNT10Bchr12

49364352

-
5UTR-5UTRENST00000541959ENST00000407467ARF3chr12

49351093

-WNT10Bchr12

49364352

-
5UTR-5UTRENST00000541959ENST00000403957ARF3chr12

49351093

-WNT10Bchr12

49364352

-
intron-5UTRENST00000541967ENST00000301061ARF3chr12

49351093

-WNT10Bchr12

49364352

-
intron-5UTRENST00000541967ENST00000407467ARF3chr12

49351093

-WNT10Bchr12

49364352

-
intron-5UTRENST00000541967ENST00000403957ARF3chr12

49351093

-WNT10Bchr12

49364352

-

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FusionProtFeatures for ARF3_WNT10B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARF3

P61204

WNT10B

O00744

GTP-binding protein that functions as an allostericactivator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulatevesicle budding and uncoating within the Golgi apparatus. Member of the Wnt ligand gene family that encodes forsecreted proteins, which activate the Wnt signaling cascade.Specifically activates canonical Wnt/beta-catenin signaling andthus triggers beta-catenin/LEF/TCF-mediated transcriptionalprograms. Involved in signaling networks controlling stemness,pluripotency and cell fate decisions. Acts in the immune system,mammary gland, adipose tissue, bone and skin.{ECO:0000305|PubMed:16477437, ECO:0000305|PubMed:21447090,ECO:0000305|PubMed:27321946}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARF3_WNT10B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARF3_WNT10B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARF3ARFIP2, ARFIP1, GGA2, GGA1, GGA3, KIF23, ELAVL1, SIRT7, SLC2A4, ATN1, ARF1, ITGA4, MMS19, CLN3, FAF2, HNRNPA1, CDC73, FOXA1, TRIM25WNT10BPPP2R2D, PPP6R2, FSTL1, COL6A2, JMJD8, LRP6, MCPH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARF3_WNT10B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARF3_WNT10B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWNT10BC1458155Mammary Neoplasms1CTD_human
TgeneWNT10BC2749665SPLIT-HAND/FOOT MALFORMATION 6 (disorder)1CTD_human;UNIPROT