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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23244

FusionGeneSummary for MYT1_TCEA2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYT1_TCEA2
Fusion gene ID: 23244
HgeneTgene
Gene symbol

MYT1

TCEA2

Gene ID

9088

6919

Gene nameprotein kinase, membrane associated tyrosine/threonine 1transcription elongation factor A2
SynonymsMYT1|PPP1R126TFIIS
Cytomap

16p13.3

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasemyt1 kinaseprotein phosphatase 1, regulatory subunit 126transcription elongation factor A protein 2testis-specific S-IItranscription elongation factor A (SII), 2transcription elongation factor S-II protein 2transcription elongation factor TFIIS.1transcription elongation factor TFIIS.l
Modification date2018052320180519
UniProtAcc

Q01538

Q15560

Ensembl transtripts involved in fusion geneENST00000360149, ENST00000536311, 
ENST00000328439, 
ENST00000361317, 
ENST00000343484, ENST00000395053, 
ENST00000465111, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 2 X 1=2
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/2*10)=2.32192809488736
Context

PubMed: MYT1 [Title/Abstract] AND TCEA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYT1

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-77-8140-01AMYT1chr20

62783263

+TCEA2chr20

62697829

+
TCGALDLUSCTCGA-77-8140-01AMYT1chr20

62783263

+TCEA2chr20

62693783

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000360149ENST00000361317MYT1chr20

62783263

+TCEA2chr20

62697829

+
5UTR-5UTRENST00000360149ENST00000343484MYT1chr20

62783263

+TCEA2chr20

62697829

+
5UTR-5UTRENST00000360149ENST00000395053MYT1chr20

62783263

+TCEA2chr20

62697829

+
5UTR-3UTRENST00000360149ENST00000465111MYT1chr20

62783263

+TCEA2chr20

62697829

+
intron-5UTRENST00000536311ENST00000361317MYT1chr20

62783263

+TCEA2chr20

62697829

+
intron-5UTRENST00000536311ENST00000343484MYT1chr20

62783263

+TCEA2chr20

62697829

+
intron-5UTRENST00000536311ENST00000395053MYT1chr20

62783263

+TCEA2chr20

62697829

+
intron-3UTRENST00000536311ENST00000465111MYT1chr20

62783263

+TCEA2chr20

62697829

+
intron-5UTRENST00000328439ENST00000361317MYT1chr20

62783263

+TCEA2chr20

62697829

+
intron-5UTRENST00000328439ENST00000343484MYT1chr20

62783263

+TCEA2chr20

62697829

+
intron-5UTRENST00000328439ENST00000395053MYT1chr20

62783263

+TCEA2chr20

62697829

+
intron-3UTRENST00000328439ENST00000465111MYT1chr20

62783263

+TCEA2chr20

62697829

+
5UTR-5UTRENST00000360149ENST00000361317MYT1chr20

62783263

+TCEA2chr20

62693783

+
5UTR-intronENST00000360149ENST00000343484MYT1chr20

62783263

+TCEA2chr20

62693783

+
5UTR-intronENST00000360149ENST00000395053MYT1chr20

62783263

+TCEA2chr20

62693783

+
5UTR-intronENST00000360149ENST00000465111MYT1chr20

62783263

+TCEA2chr20

62693783

+
intron-5UTRENST00000536311ENST00000361317MYT1chr20

62783263

+TCEA2chr20

62693783

+
intron-intronENST00000536311ENST00000343484MYT1chr20

62783263

+TCEA2chr20

62693783

+
intron-intronENST00000536311ENST00000395053MYT1chr20

62783263

+TCEA2chr20

62693783

+
intron-intronENST00000536311ENST00000465111MYT1chr20

62783263

+TCEA2chr20

62693783

+
intron-5UTRENST00000328439ENST00000361317MYT1chr20

62783263

+TCEA2chr20

62693783

+
intron-intronENST00000328439ENST00000343484MYT1chr20

62783263

+TCEA2chr20

62693783

+
intron-intronENST00000328439ENST00000395053MYT1chr20

62783263

+TCEA2chr20

62693783

+
intron-intronENST00000328439ENST00000465111MYT1chr20

62783263

+TCEA2chr20

62693783

+

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FusionProtFeatures for MYT1_TCEA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYT1

Q01538

TCEA2

Q15560

Binds to the promoter region of genes encodingproteolipid proteins of the central nervous system. May play arole in the development of neurons and oligodendroglia in the CNS.May regulate a critical transition point in oligodendrocytelineage development by modulating oligodendrocyte progenitorproliferation relative to terminal differentiation and up-regulation of myelin gene transcription.{ECO:0000269|PubMed:14962745}. Necessary for efficient RNA polymerase II transcriptionelongation past template-encoded arresting sites. The arrestingsites in DNA have the property of trapping a certain fraction ofelongating RNA polymerases that pass through, resulting in lockedternary complexes. Cleavage of the nascent transcript by S-IIallows the resumption of elongation from the new 3'-terminus.{ECO:0000269|PubMed:12034815}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYT1_TCEA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYT1_TCEA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYT1PIN1, SIN3B, HDAC1, TRAF3, AURKATCEA2MAGEA11, TRAF2, AKT1S1, FBF1, CENPT, WDR47, CCSER2, RPA1, SH3GL2, TAX1BP3, DNAJB9, MARK3, CAMKV, MCM2, CAND1, HNRNPK, TNPO1, PNN, EIF4A3, TCEA1, SNW1, NELFA, PARP1, KLC4, MAGED2, POLR2J, APP, LSM4, DHX16, CPSF6, DHRS2, ALAS1, DAB1, GOLGA2, KRTAP5-9, MEOX2, TRIM27, TCF4, TFCP2, MKRN3, TAX1BP1, TNIP1, MID2, EXOSC8, GPKOW, ADAMTSL4, THAP1, TRIM54, CCDC136, TSGA10, CEP44, LZTS2, KRT40, KIAA1958, FAM9B, KRTAP10-7, BRCA1, KXD1, MYH9, ANLN, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYT1_TCEA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYT1_TCEA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTCEA2C0023467Leukemia, Myelocytic, Acute1CTD_human