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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23235

FusionGeneSummary for MYSM1_APOM

check button Fusion gene summary
Fusion gene informationFusion gene name: MYSM1_APOM
Fusion gene ID: 23235
HgeneTgene
Gene symbol

MYSM1

APOM

Gene ID

114803

55937

Gene nameMyb like, SWIRM and MPN domains 1apolipoprotein M
Synonyms2A-DUB|2ADUBG3a|HSPC336|NG20|apo-M
Cytomap

1p32.1

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionhistone H2A deubiquitinase MYSM1myb-like, SWIRM and MPN domain-containing protein 1apolipoprotein MNG20-like proteinalternative name: G3a, NG20protein G3a
Modification date2018052220180519
UniProtAcc

Q5VVJ2

O95445

Ensembl transtripts involved in fusion geneENST00000472487, ENST00000493821, 
ENST00000375918, ENST00000375920, 
ENST00000375916, ENST00000452949, 
ENST00000416324, ENST00000430282, 
ENST00000426401, ENST00000439902, 
ENST00000426800, ENST00000425856, 
ENST00000422771, ENST00000441436, 
ENST00000419996, ENST00000400157, 
ENST00000383438, ENST00000440956, 
ENST00000443975, ENST00000436931, 
ENST00000430238, ENST00000425177, 
ENST00000432598, 
Fusion gene scores* DoF score4 X 3 X 3=362 X 1 X 2=4
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: MYSM1 [Title/Abstract] AND APOM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPOM

GO:0033344

cholesterol efflux

16682745

TgeneAPOM

GO:0034445

negative regulation of plasma lipoprotein oxidation

16682745|22204862


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A18L-01AMYSM1chr1

59160801

-APOMchr6

31624249

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000472487ENST00000375918MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-5UTRENST00000472487ENST00000375920MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-5UTRENST00000472487ENST00000375916MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000452949MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000416324MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000430282MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000426401MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000439902MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000426800MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000425856MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000422771MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000441436MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000419996MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000400157MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000383438MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000440956MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000443975MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000436931MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000430238MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000425177MYSM1chr1

59160801

-APOMchr6

31624249

+
5CDS-intronENST00000472487ENST00000432598MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-5UTRENST00000493821ENST00000375918MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-5UTRENST00000493821ENST00000375920MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-5UTRENST00000493821ENST00000375916MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000452949MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000416324MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000430282MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000426401MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000439902MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000426800MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000425856MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000422771MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000441436MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000419996MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000400157MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000383438MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000440956MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000443975MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000436931MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000430238MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000425177MYSM1chr1

59160801

-APOMchr6

31624249

+
intron-intronENST00000493821ENST00000432598MYSM1chr1

59160801

-APOMchr6

31624249

+

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FusionProtFeatures for MYSM1_APOM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYSM1

Q5VVJ2

APOM

O95445

Metalloprotease that specifically deubiquitinatesmonoubiquitinated histone H2A, a specific tag for epigenetictranscriptional repression, thereby acting as a coactivator.Preferentially deubiquitinates monoubiquitinated H2A inhyperacetylated nucleosomes. Deubiquitination of histone H2A leadsto facilitate the phosphorylation and dissociation of histone H1from the nucleosome. Acts as a coactivator by participating in theinitiation and elongation steps of androgen receptor (AR)-inducedgene activation. {ECO:0000269|PubMed:17707232}. Probably involved in lipid transport. Can bindsphingosine-1-phosphate, myristic acid, palmitic acid and stearicacid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.{ECO:0000269|PubMed:17525477, ECO:0000269|PubMed:19733574}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYSM1_APOM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYSM1_APOM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYSM1HIST2H2AC, WDR77, HNRNPH1, TUBB1, EEF1A1, STK38, PRMT5, HSPA1A, UBC, KAT2B, RBM10, KIF11, DICER1APOMKLF6, HGH1, CT45A2, USP16, SEC11C, CNTNAP3, CDYL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYSM1_APOM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYSM1_APOM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource