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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23234

FusionGeneSummary for MYSM1_ALG14

check button Fusion gene summary
Fusion gene informationFusion gene name: MYSM1_ALG14
Fusion gene ID: 23234
HgeneTgene
Gene symbol

MYSM1

ALG14

Gene ID

114803

199857

Gene nameMyb like, SWIRM and MPN domains 1ALG14, UDP-N-acetylglucosaminyltransferase subunit
Synonyms2A-DUB|2ADUBCMS15
Cytomap

1p32.1

1p21.3

Type of geneprotein-codingprotein-coding
Descriptionhistone H2A deubiquitinase MYSM1myb-like, SWIRM and MPN domain-containing protein 1UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Modification date2018052220180519
UniProtAcc

Q5VVJ2

Q96F25

Ensembl transtripts involved in fusion geneENST00000472487, ENST00000493821, 
ENST00000370205, ENST00000495856, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 3 X 4=48
# samples 46
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYSM1 [Title/Abstract] AND ALG14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A7-A5ZV-01AMYSM1chr1

59165657

-ALG14chr1

95448862

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000472487ENST00000370205MYSM1chr1

59165657

-ALG14chr1

95448862

-
5CDS-intronENST00000472487ENST00000495856MYSM1chr1

59165657

-ALG14chr1

95448862

-
intron-3CDSENST00000493821ENST00000370205MYSM1chr1

59165657

-ALG14chr1

95448862

-
intron-intronENST00000493821ENST00000495856MYSM1chr1

59165657

-ALG14chr1

95448862

-

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FusionProtFeatures for MYSM1_ALG14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYSM1

Q5VVJ2

ALG14

Q96F25

Metalloprotease that specifically deubiquitinatesmonoubiquitinated histone H2A, a specific tag for epigenetictranscriptional repression, thereby acting as a coactivator.Preferentially deubiquitinates monoubiquitinated H2A inhyperacetylated nucleosomes. Deubiquitination of histone H2A leadsto facilitate the phosphorylation and dissociation of histone H1from the nucleosome. Acts as a coactivator by participating in theinitiation and elongation steps of androgen receptor (AR)-inducedgene activation. {ECO:0000269|PubMed:17707232}. May be involved in protein N-glycosylation. May play arole in the second step of the dolichol-linked oligosaccharidepathway. May anchor the catalytic subunit ALG13 to the ER.{ECO:0000269|PubMed:16100110}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYSM1_ALG14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYSM1_ALG14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYSM1HIST2H2AC, WDR77, HNRNPH1, TUBB1, EEF1A1, STK38, PRMT5, HSPA1A, UBC, KAT2B, RBM10, KIF11, DICER1ALG14HAUS7, FADS3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYSM1_ALG14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYSM1_ALG14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneALG14C4015596MYASTHENIC SYNDROME, CONGENITAL, 151UNIPROT