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Fusion gene ID: 23228 |
FusionGeneSummary for MYRFL_KCNMB4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYRFL_KCNMB4 | Fusion gene ID: 23228 | Hgene | Tgene | Gene symbol | MYRFL | KCNMB4 | Gene ID | 196446 | 27345 |
| Gene name | myelin regulatory factor like | potassium calcium-activated channel subfamily M regulatory beta subunit 4 | |
| Synonyms | C12orf15|C12orf28|bcm1377 | - | |
| Cytomap | 12q15 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myelin regulatory factor-like protein | calcium-activated potassium channel subunit beta-4BK channel beta subunit 4BK channel subunit beta-4BKbeta4MaxiK channel beta-subunit 4big potassium channel beta subunit 4calcium-activated potassium channel, subfamily M subunit beta-4charybdotoxin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96LU7 | Q86W47 | |
| Ensembl transtripts involved in fusion gene | ENST00000552032, ENST00000547771, ENST00000299350, ENST00000535034, | ENST00000258111, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 10 X 4 X 6=240 |
| # samples | 2 | 10 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYRFL [Title/Abstract] AND KCNMB4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KCNMB4 | GO:0001508 | action potential | 10692449 |
| Tgene | KCNMB4 | GO:0005513 | detection of calcium ion | 10692449 |
| Tgene | KCNMB4 | GO:0006813 | potassium ion transport | 10692449 |
| Tgene | KCNMB4 | GO:0019228 | neuronal action potential | 10692449 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-AB2H-01A | MYRFL | chr12 | 70321528 | + | KCNMB4 | chr12 | 70824265 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000552032 | ENST00000258111 | MYRFL | chr12 | 70321528 | + | KCNMB4 | chr12 | 70824265 | + |
| In-frame | ENST00000547771 | ENST00000258111 | MYRFL | chr12 | 70321528 | + | KCNMB4 | chr12 | 70824265 | + |
| 5UTR-3CDS | ENST00000299350 | ENST00000258111 | MYRFL | chr12 | 70321528 | + | KCNMB4 | chr12 | 70824265 | + |
| intron-3CDS | ENST00000535034 | ENST00000258111 | MYRFL | chr12 | 70321528 | + | KCNMB4 | chr12 | 70824265 | + |
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FusionProtFeatures for MYRFL_KCNMB4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYRFL | KCNMB4 |
| Regulatory subunit of the calcium activated potassiumKCNMA1 (maxiK) channel. Modulates the calcium sensitivity andgating kinetics of KCNMA1, thereby contributing to KCNMA1 channeldiversity. Decreases the gating kinetics and calcium sensitivityof the KCNMA1 channel, but with fast deactivation kinetics. Maydecrease KCNMA1 channel openings at low calcium concentrations butincreases channel openings at high calcium concentrations. MakesKCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxinconcentrations. {ECO:0000269|PubMed:10692449,ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MYRFL | chr12:70321528 | chr12:70824265 | ENST00000552032 | + | 15 | 25 | 543_575 | 610 | 911 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MYRFL | chr12:70321528 | chr12:70824265 | ENST00000552032 | + | 15 | 25 | 142_405 | 610 | 911 | DNA binding | NDT80 |
| Hgene | MYRFL | chr12:70321528 | chr12:70824265 | ENST00000552032 | + | 15 | 25 | 451_559 | 610 | 911 | Domain | Peptidase S74 |
| Tgene | >KCNMB4 | chr12:70321528 | chr12:70824265 | ENST00000258111 | + | 1 | 3 | 189_210 | 154 | 211 | Topological domain | Cytoplasmic |
| Tgene | >KCNMB4 | chr12:70321528 | chr12:70824265 | ENST00000258111 | + | 1 | 3 | 168_188 | 154 | 211 | Transmembrane | Helical%3B Name%3D2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MYRFL | chr12:70321528 | chr12:70824265 | ENST00000552032 | + | 15 | 25 | 628_648 | 610 | 911 | Transmembrane | Helical |
| Tgene | KCNMB4 | chr12:70321528 | chr12:70824265 | ENST00000258111 | + | 1 | 3 | 1_19 | 154 | 211 | Topological domain | Cytoplasmic |
| Tgene | KCNMB4 | chr12:70321528 | chr12:70824265 | ENST00000258111 | + | 1 | 3 | 41_167 | 154 | 211 | Topological domain | Extracellular |
| Tgene | KCNMB4 | chr12:70321528 | chr12:70824265 | ENST00000258111 | + | 1 | 3 | 20_40 | 154 | 211 | Transmembrane | Helical%3B Name%3D1 |
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FusionGeneSequence for MYRFL_KCNMB4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MYRFL_ENST00000552032_chr12_70321528_+_KCNMB4_ENST00000258111_chr12_70824265_+_666aa MDVVGENEALQQFFEAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPT AAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWA CHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITI HIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPN PDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHP SDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFME NVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKTRXCASASHSXXDCPPALLP >In-frame_MYRFL_ENST00000547771_chr12_70321528_+_KCNMB4_ENST00000258111_chr12_70824265_+_666aa MDVVGENEALQQFFEAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPT AAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWA CHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITI HIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPN PDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHP SDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFME NVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKTRXCASASHSXXDCPPALLP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MYRFL_ENST00000552032_chr12_70321528_+_KCNMB4_ENST00000258111_chr12_70824265_+_1999nt ATGGATGTGGTAGGCGAAAATGAGGCCCTGCAGCAGTTCTTTGAAGCTCAGGGAGCCAATGGTACTCTGGAGAACCCAGCCCTGGACACA AGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGAC TCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACA GCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGC CACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTG TGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCC TGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAG TGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGC TATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATT CACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACT AAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTA CTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAAT CCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGG ATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGT CACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCC TCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGAC TACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGA GCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAA AATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCC CGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCA AGAAGGGCCGTTCATAAAAAAAACAACAAGACCAGATGATGTGCTTCTGCATCGCACTCATGATGAGATTGTCCTCCTGCATTGCTTCCT CTGGCCCCTGGTGACATTTGTGGTGGGCGTTCTCATTGTGGTCCTGACCATCTGTGCCAAGAGCTTGGCGGTCAAGGCGGAAGCCATGAA >In-frame_MYRFL_ENST00000547771_chr12_70321528_+_KCNMB4_ENST00000258111_chr12_70824265_+_1999nt ATGGATGTGGTAGGCGAAAATGAGGCCCTGCAGCAGTTCTTTGAAGCTCAGGGAGCCAATGGTACTCTGGAGAACCCAGCCCTGGACACA AGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGAC TCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACA GCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGC CACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTG TGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCC TGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAG TGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGC TATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATT CACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACT AAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTA CTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAAT CCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGG ATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGT CACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCC TCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGAC TACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGA GCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAA AATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCC CGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCA AGAAGGGCCGTTCATAAAAAAAACAACAAGACCAGATGATGTGCTTCTGCATCGCACTCATGATGAGATTGTCCTCCTGCATTGCTTCCT CTGGCCCCTGGTGACATTTGTGGTGGGCGTTCTCATTGTGGTCCTGACCATCTGTGCCAAGAGCTTGGCGGTCAAGGCGGAAGCCATGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MYRFL_ENST00000552032_chr12_70321528_+_KCNMB4_ENST00000258111_chr12_70824265_+_5852nt TGGTTGTATATCCTTCCAGTTTTATAATCACATTTGAAAACTCAACCATCTTTCTGGGCACAATTTGATGGCTGAAGATATGCTTCACTC CAATAAAAAGAAAATGAAGATTTTTCAAGAGCATTCGTAGGCTTCGAATCAAAAGGACAGTACTTATTTCCTGAGGTCTGATAACCGTTG TTTTATGAGGAAATAGTACTAGGATCACAGTACCATGGATGTGGTAGGCGAAAATGAGGCCCTGCAGCAGTTCTTTGAAGCTCAGGGAGC CAATGGTACTCTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCA GCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGC TGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGA CTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCT GGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGC ACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGA CAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATT AAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGT TTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCC AATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAG CAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCAC AGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCA GTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTG GCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGG CAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAA AAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAAT GATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTT CCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAAT AGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAG CAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGACCAGATGATGTGCTTCTGCATCGCA CTCATGATGAGATTGTCCTCCTGCATTGCTTCCTCTGGCCCCTGGTGACATTTGTGGTGGGCGTTCTCATTGTGGTCCTGACCATCTGTG CCAAGAGCTTGGCGGTCAAGGCGGAAGCCATGAAGAAGCGCAAGTTCTCTTAAAGGGGAAGGAGGCTTGTAGAAAGCAAAGTACAGAAGC TGTACTCATCGGCACGCGTCCACCTGCGGAACCTGTGTTTCCTGGCGCAGGAGATGGACAGGGCCACGACAGGGCTCTGAGAGGCTCATC CCTCAGTGGCAACAGAAACAGGCACAACTGGAAGACTTGGAACCTCAAAGCTTGTATTCCATCTGCTGTAGCAATGGCTAAAGGGTCAAG ATCTTAGCTGTATGGAGTAACTATTTCAGAAAACCCTATAAGAAGTTCATTTTCTTTCAAAAGTAACAGTATATTATTTGTACAGTGTAG TATACAAACCATTATGATTTATGCTACTTAAAAATATTAAAATAGAGTGGTCTGTGTTATTTTCTATTTCCTTTTTTATGCTTAGAACAC CAGGGTTTAAAAAAAAAAAAAAGGTGAGGACATCTGGGTCTCATTTGCTTCTGCTAGGTTAAACTTTTACTTGACAACAAGGATTCCTGC TGAAGTCTGAACCTTACTGTGTAACCCTCAGTTTCCACTATTAAAGAGTATCTTTTGACGTCTGCTTGGAAAATGAATAGTATACTGGTA ACTCAGTCTCCAGTCACCTCTGTGTCTCTTAAGCAAGAGATTCTAAAAGATTGGGAAAACATATCCTCCAACACCTGCCTTTGCCTAACC ATTATTTTTCACCAGATTACTTCTTAAGAGAGGGAGGTGATTCTGAAGAAGGCTTCTATCTCAAAAAGCACTGGGCTTCCTTATTCATCT GTTCTTGTTGTTTTTGACGGAGTTAAAAAAGTTTGTGTGCAATACAATATACATGATGTGAAGGACACTCTTCAGCTTAGTGAAACGCTG TTTTCATTTTTTTTTTTTTTTGTAGGTCAGAAAAAAACAACAAAATCAGTTCAAGCATTTTTTTTTCTTTGTCCTTGCCTTGATGTTATG AGTATTAAAACCAGGAGGATTGCTGCCATTGTGCAGTTTGCTTAGACAAACCTGGAGATGCAACCCAGCTCACATCATTGCTACTGATGA GCTTTCTGTGCCTTTATCAAAAGTTGATTGAGAAGACCATATTTCTTTGTATCTTTTTATAAACTCAAATTCCAAGTATCAAATCGCAGG TCTCAGTGAACATCAAACCTATTTACTACATAGAATCAAACCTTTGTTTAGGTGAGATGTACATCGTTAGTGGAGGAAAAACTGACAACC TAATTTCATTTGTTTTCTTCTGATACTCTTCAGACATGCCTCTATTAGAATAAAGGTAAACTGGAATTTAAAGACAAGTTCCCCTCAGTT ATTTCCATGGAGCTGTAATATGTATATATGGAGTGATGGTTTCCTGACCTTTAGTCCACATACCAATGTTTTCTTTTTTCTTTTTTTTTT TTTTTTTTGAGATGGTGTCTCACTCTGTTGCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTACAGTCTCCACCTCCTGGGTTCAA GTCATTCCTCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACGCACCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGAC GGGGTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGATCTGCCCACTTCACCTCCCAAAGTGCTGGGATTACAGGCCA ATGTTTTCTTAATCTTAGAATGTGAATAACTGAAAATCATAGTCTGTGGAAAGGTGTTGAATTGAGTATAATCTTCTTCTGTTTATTTTT GTGTTTTGTTTTTTAACAGATGGGTATCTTGCTATGTTGCCCAGGATGGAGTGCAGTAGCTATTCACAGGTATGATCATAGCACACTGCA GCCTCAAGCTCCTGGGCTCAAGCGATCCCCCTCCCTCAGCCTCCCAAGTATCTGGGGTTACTGGTGTGCACCACCGTGCTTGGCTCCAAT AATTTTTTTTCTAATTCAAAAGTTACAGTTTCACTGTGAAAAAGGCCTTGAACACACTATTTATGACATCTTTTGAGGCAGCTCCAGTGC CTTGACTTCAATCCCAGTTTCCGGTTGCAGCATCCTTGTTGTCTTAGCAACACAGTGAACTATTCTGAAGCATAGAGTAACACGAAACTG GGAGTCCGAGAAATAATCATCTCTGCATCACATTATGGGAGACGAAGTCTGCTTTATCCATTTTATCTTTATTCAGTTGTCTATGATTAA TTGATTACAGAGTAGTAGATTAGAATAGTGCATGGATATACATTTGTGTTGAAAAAAGGGGAAGTTGATATATATCAATCTTAGTTTTCA TTTATCAGTTTGATATTCATGCATTTACACTAAACGCTTCCATTTATCCCGAAAAAGTATATGCAACTGTATTCTGTAGGTTGATTTTTG GAAAAGGGGAGAAGCACACTGAATTCATAAGGTCACATGTAGTCTTAAGGTCTTACTTGCTTACAGCCAATTAAATTTGAAGCACCTTAT TTATACTTGTTAAAGGTAAAACCCAAAAGAACAAGCAGAGGACATTTTAAGGTCATAAAAGGTAAATAAGCTTACCTTCTTAATGTTTTC ATTCTCTTTTTGTATAAATCAGAAAATGATCTAAACTGCTGTAACAAAGAGACCCCAAAATATGATGGCTCATGTAAGATAATTTATTTT TTTCTCACATAGCAATCCAGAAGTGGCTTCATTTCACAAGGTATTCAAGGGATATAGGAGTCATCTACCTTGTTAGTTCTCTTAATACCC AAGGGTATTGTTCTTTCCATGGTCAAAGCTGGCTCAAGACTTCCTAGCCTGTGAAAAAAGAAGAAGGTGGAGCAAGCCATTTCCTTTTTA GGAAATTACAGCCATCACTTCTGCCCACCGTCCATTCATGAATACTTACTATATAGCTATACCTAGCTTCAAGAAAGCCTGGGACGTGTC TCTAACTAGATGGACATGTGCCCTACTAAAACTCCAGGGAAAGGGTTCTATTACTAAAGCTAAAAAGAGGGGAATGAATACTAGAGTTAA AGACAAAAATGATAGCAGCCAATGGCCCATGCCGTGATAATCTGCTGAGCAGGCATGATGGAGATCCCTTGCCCAGCAGAAAGTGTTCCT TGGTGAAATCATGAATCTGCTATCTAGGAGAAACTCCCTTGTCCATTGTCTTCTGTGGCCACTAGTTTGACCTCTAGGAAAGTCTTGCTC GTCAGCTTCTGTGGCCCCGTCTGAAACTTTTGAGGGACATCGCAGCTTTTGCAGCCCCTGCTTGCTGGTGCAGACTTTTAGACCTAGATT GCCTTAGAGACTGAAAAATATACGCTTTTATAGGCCGGGGTTTTAGTTCATTTGACTGTAATAAAGACGTCAATGCCGTTTTTAATGTTT GACTGCTGACATCTTTCAAGACTCACCTTTCCCTTCTCCCTTATGCTGCACATCTGGGCAAGCTGATGGAAGCATGGGTGCCTCCTCCTT TGGCCCCAGCAGGAAGTTCAAATCACGCAAGCCCTGGCATGCATGCAGGAAGCTTCACCCCAGCCTCACACTCTAAGACGGATAAAAGCC AAACCAATTAAGCCGTTTCTCGACCCTCCTGGGAGCCTGCCCTATCTCCCTGGAAAGTCTCAGTATGTGAGTAATAAACCTTTTTATACC >In-frame_MYRFL_ENST00000547771_chr12_70321528_+_KCNMB4_ENST00000258111_chr12_70824265_+_5840nt CTTCCAGTTTTATAATCACATTTGAAAACTCAACCATCTTTCTGGGCACAATTTGATGGCTGAAGATATGCTTCACTCCAATAAAAAGAA AATGAAGATTTTTCAAGAGCATTCGTAGGCTTCGAATCAAAAGGACAGTACTTATTTCCTGAGGTCTGATAACCGTTGTTTTATGAGGAA ATAGTACTAGGATCACAGTACCATGGATGTGGTAGGCGAAAATGAGGCCCTGCAGCAGTTCTTTGAAGCTCAGGGAGCCAATGGTACTCT GGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGACAC CCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACTCC AGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAAAT CCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGTTG TTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGACTC CGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGACA GAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCATTA TGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAGAA GAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATGTT TTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATTTT CAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAATAT GAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTGTT GTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGACA AGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAAGT GATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCCCA AATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAGGA GGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTGGA TAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTAGA AATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGCAG AGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGACCAGATGATGTGCTTCTGCATCGCACTCATGATGAGA TTGTCCTCCTGCATTGCTTCCTCTGGCCCCTGGTGACATTTGTGGTGGGCGTTCTCATTGTGGTCCTGACCATCTGTGCCAAGAGCTTGG CGGTCAAGGCGGAAGCCATGAAGAAGCGCAAGTTCTCTTAAAGGGGAAGGAGGCTTGTAGAAAGCAAAGTACAGAAGCTGTACTCATCGG CACGCGTCCACCTGCGGAACCTGTGTTTCCTGGCGCAGGAGATGGACAGGGCCACGACAGGGCTCTGAGAGGCTCATCCCTCAGTGGCAA CAGAAACAGGCACAACTGGAAGACTTGGAACCTCAAAGCTTGTATTCCATCTGCTGTAGCAATGGCTAAAGGGTCAAGATCTTAGCTGTA TGGAGTAACTATTTCAGAAAACCCTATAAGAAGTTCATTTTCTTTCAAAAGTAACAGTATATTATTTGTACAGTGTAGTATACAAACCAT TATGATTTATGCTACTTAAAAATATTAAAATAGAGTGGTCTGTGTTATTTTCTATTTCCTTTTTTATGCTTAGAACACCAGGGTTTAAAA AAAAAAAAAAGGTGAGGACATCTGGGTCTCATTTGCTTCTGCTAGGTTAAACTTTTACTTGACAACAAGGATTCCTGCTGAAGTCTGAAC CTTACTGTGTAACCCTCAGTTTCCACTATTAAAGAGTATCTTTTGACGTCTGCTTGGAAAATGAATAGTATACTGGTAACTCAGTCTCCA GTCACCTCTGTGTCTCTTAAGCAAGAGATTCTAAAAGATTGGGAAAACATATCCTCCAACACCTGCCTTTGCCTAACCATTATTTTTCAC CAGATTACTTCTTAAGAGAGGGAGGTGATTCTGAAGAAGGCTTCTATCTCAAAAAGCACTGGGCTTCCTTATTCATCTGTTCTTGTTGTT TTTGACGGAGTTAAAAAAGTTTGTGTGCAATACAATATACATGATGTGAAGGACACTCTTCAGCTTAGTGAAACGCTGTTTTCATTTTTT TTTTTTTTTGTAGGTCAGAAAAAAACAACAAAATCAGTTCAAGCATTTTTTTTTCTTTGTCCTTGCCTTGATGTTATGAGTATTAAAACC AGGAGGATTGCTGCCATTGTGCAGTTTGCTTAGACAAACCTGGAGATGCAACCCAGCTCACATCATTGCTACTGATGAGCTTTCTGTGCC TTTATCAAAAGTTGATTGAGAAGACCATATTTCTTTGTATCTTTTTATAAACTCAAATTCCAAGTATCAAATCGCAGGTCTCAGTGAACA TCAAACCTATTTACTACATAGAATCAAACCTTTGTTTAGGTGAGATGTACATCGTTAGTGGAGGAAAAACTGACAACCTAATTTCATTTG TTTTCTTCTGATACTCTTCAGACATGCCTCTATTAGAATAAAGGTAAACTGGAATTTAAAGACAAGTTCCCCTCAGTTATTTCCATGGAG CTGTAATATGTATATATGGAGTGATGGTTTCCTGACCTTTAGTCCACATACCAATGTTTTCTTTTTTCTTTTTTTTTTTTTTTTTTGAGA TGGTGTCTCACTCTGTTGCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTACAGTCTCCACCTCCTGGGTTCAAGTCATTCCTCTG CCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACGCACCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCG TGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGATCTGCCCACTTCACCTCCCAAAGTGCTGGGATTACAGGCCAATGTTTTCTTAA TCTTAGAATGTGAATAACTGAAAATCATAGTCTGTGGAAAGGTGTTGAATTGAGTATAATCTTCTTCTGTTTATTTTTGTGTTTTGTTTT TTAACAGATGGGTATCTTGCTATGTTGCCCAGGATGGAGTGCAGTAGCTATTCACAGGTATGATCATAGCACACTGCAGCCTCAAGCTCC TGGGCTCAAGCGATCCCCCTCCCTCAGCCTCCCAAGTATCTGGGGTTACTGGTGTGCACCACCGTGCTTGGCTCCAATAATTTTTTTTCT AATTCAAAAGTTACAGTTTCACTGTGAAAAAGGCCTTGAACACACTATTTATGACATCTTTTGAGGCAGCTCCAGTGCCTTGACTTCAAT CCCAGTTTCCGGTTGCAGCATCCTTGTTGTCTTAGCAACACAGTGAACTATTCTGAAGCATAGAGTAACACGAAACTGGGAGTCCGAGAA ATAATCATCTCTGCATCACATTATGGGAGACGAAGTCTGCTTTATCCATTTTATCTTTATTCAGTTGTCTATGATTAATTGATTACAGAG TAGTAGATTAGAATAGTGCATGGATATACATTTGTGTTGAAAAAAGGGGAAGTTGATATATATCAATCTTAGTTTTCATTTATCAGTTTG ATATTCATGCATTTACACTAAACGCTTCCATTTATCCCGAAAAAGTATATGCAACTGTATTCTGTAGGTTGATTTTTGGAAAAGGGGAGA AGCACACTGAATTCATAAGGTCACATGTAGTCTTAAGGTCTTACTTGCTTACAGCCAATTAAATTTGAAGCACCTTATTTATACTTGTTA AAGGTAAAACCCAAAAGAACAAGCAGAGGACATTTTAAGGTCATAAAAGGTAAATAAGCTTACCTTCTTAATGTTTTCATTCTCTTTTTG TATAAATCAGAAAATGATCTAAACTGCTGTAACAAAGAGACCCCAAAATATGATGGCTCATGTAAGATAATTTATTTTTTTCTCACATAG CAATCCAGAAGTGGCTTCATTTCACAAGGTATTCAAGGGATATAGGAGTCATCTACCTTGTTAGTTCTCTTAATACCCAAGGGTATTGTT CTTTCCATGGTCAAAGCTGGCTCAAGACTTCCTAGCCTGTGAAAAAAGAAGAAGGTGGAGCAAGCCATTTCCTTTTTAGGAAATTACAGC CATCACTTCTGCCCACCGTCCATTCATGAATACTTACTATATAGCTATACCTAGCTTCAAGAAAGCCTGGGACGTGTCTCTAACTAGATG GACATGTGCCCTACTAAAACTCCAGGGAAAGGGTTCTATTACTAAAGCTAAAAAGAGGGGAATGAATACTAGAGTTAAAGACAAAAATGA TAGCAGCCAATGGCCCATGCCGTGATAATCTGCTGAGCAGGCATGATGGAGATCCCTTGCCCAGCAGAAAGTGTTCCTTGGTGAAATCAT GAATCTGCTATCTAGGAGAAACTCCCTTGTCCATTGTCTTCTGTGGCCACTAGTTTGACCTCTAGGAAAGTCTTGCTCGTCAGCTTCTGT GGCCCCGTCTGAAACTTTTGAGGGACATCGCAGCTTTTGCAGCCCCTGCTTGCTGGTGCAGACTTTTAGACCTAGATTGCCTTAGAGACT GAAAAATATACGCTTTTATAGGCCGGGGTTTTAGTTCATTTGACTGTAATAAAGACGTCAATGCCGTTTTTAATGTTTGACTGCTGACAT CTTTCAAGACTCACCTTTCCCTTCTCCCTTATGCTGCACATCTGGGCAAGCTGATGGAAGCATGGGTGCCTCCTCCTTTGGCCCCAGCAG GAAGTTCAAATCACGCAAGCCCTGGCATGCATGCAGGAAGCTTCACCCCAGCCTCACACTCTAAGACGGATAAAAGCCAAACCAATTAAG |
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FusionGenePPI for MYRFL_KCNMB4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MYRFL | KCNMB4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MYRFL_KCNMB4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | KCNMB4 | Q86W47 | DB01110 | Miconazole | Calcium-activated potassium channel subunit beta-4 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for MYRFL_KCNMB4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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