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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23216

FusionGeneSummary for MYOF_MYOF

check button Fusion gene summary
Fusion gene informationFusion gene name: MYOF_MYOF
Fusion gene ID: 23216
HgeneTgene
Gene symbol

MYOF

MYOF

Gene ID

26509

26509

Gene namemyoferlinmyoferlin
SynonymsFER1L3FER1L3
Cytomap

10q23.33

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionmyoferlinfer-1-like 3, myoferlinfer-1-like family member 3fer-1-like protein 3myoferlinfer-1-like 3, myoferlinfer-1-like family member 3fer-1-like protein 3
Modification date2018051920180519
UniProtAcc

Q9NZM1

Q9NZM1

Ensembl transtripts involved in fusion geneENST00000359263, ENST00000358334, 
ENST00000371501, ENST00000371502, 
ENST00000371489, ENST00000485212, 
ENST00000371488, 		ENST00000359263, 
ENST00000358334, ENST00000371501, 
ENST00000371502, ENST00000371489, 
ENST00000485212, ENST00000371488, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 3 X 2=18
# samples 45
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYOF [Title/Abstract] AND MYOF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA528800MYOFchr10

95070341

-MYOFchr10

95072776

+
ChiTaRS3.1AA664967MYOFchr10

95070341

-MYOFchr10

95072776

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000359263ENST00000359263MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000359263ENST00000358334MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000359263ENST00000371501MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000359263ENST00000371502MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000359263ENST00000371489MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000359263ENST00000485212MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000359263ENST00000371488MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000358334ENST00000359263MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000358334ENST00000358334MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000358334ENST00000371501MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000358334ENST00000371502MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000358334ENST00000371489MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000358334ENST00000485212MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000358334ENST00000371488MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371501ENST00000359263MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371501ENST00000358334MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371501ENST00000371501MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371501ENST00000371502MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371501ENST00000371489MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371501ENST00000485212MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371501ENST00000371488MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371502ENST00000359263MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371502ENST00000358334MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371502ENST00000371501MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371502ENST00000371502MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371502ENST00000371489MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371502ENST00000485212MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371502ENST00000371488MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371489ENST00000359263MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371489ENST00000358334MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371489ENST00000371501MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371489ENST00000371502MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371489ENST00000371489MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371489ENST00000485212MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371489ENST00000371488MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000485212ENST00000359263MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000485212ENST00000358334MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000485212ENST00000371501MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000485212ENST00000371502MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000485212ENST00000371489MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000485212ENST00000485212MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000485212ENST00000371488MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371488ENST00000359263MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371488ENST00000358334MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371488ENST00000371501MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371488ENST00000371502MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371488ENST00000371489MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371488ENST00000485212MYOFchr10

95070341

-MYOFchr10

95072776

+
intron-intronENST00000371488ENST00000371488MYOFchr10

95070341

-MYOFchr10

95072776

+

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FusionProtFeatures for MYOF_MYOF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYOF

Q9NZM1

MYOF

Q9NZM1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYOF_MYOF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MYOF_MYOF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MYOF_MYOF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYOF_MYOF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource