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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23209

FusionGeneSummary for MYO9B_PPM1A

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO9B_PPM1A
Fusion gene ID: 23209
HgeneTgene
Gene symbol

MYO9B

PPM1A

Gene ID

4650

5494

Gene namemyosin IXBprotein phosphatase, Mg2+/Mn2+ dependent 1A
SynonymsCELIAC4|MYR5PP2C-ALPHA|PP2CA|PP2Calpha
Cytomap

19p13.11

14q23.1

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IXbmyosin-IXbunconventional myosin-9bprotein phosphatase 1Aprotein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Modification date2018051920180519
UniProtAcc

Q13459

P35813

Ensembl transtripts involved in fusion geneENST00000595618, ENST00000594824, 
ENST00000397274, ENST00000593411, 
ENST00000325642, ENST00000529574, 
ENST00000395076, ENST00000325658, 
Fusion gene scores* DoF score13 X 8 X 7=7284 X 4 X 2=32
# samples 134
** MAII scorelog2(13/728*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYO9B [Title/Abstract] AND PPM1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYO9B

GO:0030048

actin filament-based movement

9490638

HgeneMYO9B

GO:0032011

ARF protein signal transduction

15644318

HgeneMYO9B

GO:0035385

Roundabout signaling pathway

26529257

TgenePPM1A

GO:0010991

negative regulation of SMAD protein complex assembly

16751101

TgenePPM1A

GO:0016055

Wnt signaling pathway

10644691

TgenePPM1A

GO:0016311

dephosphorylation

10644691

TgenePPM1A

GO:0030177

positive regulation of Wnt signaling pathway

10644691

TgenePPM1A

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

16751101

TgenePPM1A

GO:0035970

peptidyl-threonine dephosphorylation

11559703|20801214

TgenePPM1A

GO:0045893

positive regulation of transcription, DNA-templated

10644691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF904341MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000595618ENST00000325642MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000595618ENST00000529574MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000595618ENST00000395076MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000595618ENST00000325658MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000594824ENST00000325642MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000594824ENST00000529574MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000594824ENST00000395076MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000594824ENST00000325658MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000397274ENST00000325642MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000397274ENST00000529574MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000397274ENST00000395076MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000397274ENST00000325658MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000593411ENST00000325642MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000593411ENST00000529574MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000593411ENST00000395076MYO9Bchr19

17208315

-PPM1Achr14

60749751

-
intron-3CDSENST00000593411ENST00000325658MYO9Bchr19

17208315

-PPM1Achr14

60749751

-

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FusionProtFeatures for MYO9B_PPM1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO9B

Q13459

PPM1A

P35813

Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.Binds actin with high affinity both in the absence and presence ofATP and its mechanochemical activity is inhibited by calcium ions(PubMed:9490638). Also acts as a GTPase activator for RHOA(PubMed:9490638, PubMed:26529257). Plays a role in the regulationof cell migration via its role as RHOA GTPase activator. This isregulated by its interaction with the SLIT2 receptor ROBO1;interaction with ROBO1 impairs interaction with RHOA andsubsequent activation of RHOA GTPase activity, and thereby leadsto increased levels of active, GTP-bound RHOA (PubMed:26529257).{ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. Enzyme with a broad specificity. Negatively regulatesTGF-beta signaling through dephosphorylating SMAD2 and SMAD3,resulting in their dissociation from SMAD4, nuclear export of theSMADs and termination of the TGF-beta-mediated signaling.Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in thetermination of TNF-alpha-mediated NF-kappa-B activation throughdephosphorylating and inactivating IKBKB/IKKB.{ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYO9B_PPM1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYO9B_PPM1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYO9B_PPM1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYO9B_PPM1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYO9BC0036341Schizophrenia3PSYGENET