FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23205

FusionGeneSummary for MYO9B_KIAA1211L

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO9B_KIAA1211L
Fusion gene ID: 23205
HgeneTgene
Gene symbol

MYO9B

KIAA1211L

Gene ID

4650

343990

Gene namemyosin IXBKIAA1211 like
SynonymsCELIAC4|MYR5C2orf55
Cytomap

19p13.11

2q11.2

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IXbmyosin-IXbunconventional myosin-9buncharacterized protein KIAA1211-likeuncharacterized protein C2orf55
Modification date2018051920180329
UniProtAcc

Q13459

Q6NV74

Ensembl transtripts involved in fusion geneENST00000595618, ENST00000594824, 
ENST00000397274, ENST00000593411, 
ENST00000397899, ENST00000462314, 
Fusion gene scores* DoF score13 X 8 X 7=7281 X 1 X 1=1
# samples 131
** MAII scorelog2(13/728*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: MYO9B [Title/Abstract] AND KIAA1211L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYO9B

GO:0030048

actin filament-based movement

9490638

HgeneMYO9B

GO:0032011

ARF protein signal transduction

15644318

HgeneMYO9B

GO:0035385

Roundabout signaling pathway

26529257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U42391MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000595618ENST00000397899MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-
5CDS-intronENST00000595618ENST00000462314MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-
Frame-shiftENST00000594824ENST00000397899MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-
5CDS-intronENST00000594824ENST00000462314MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-
Frame-shiftENST00000397274ENST00000397899MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-
5CDS-intronENST00000397274ENST00000462314MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-
intron-3CDSENST00000593411ENST00000397899MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-
intron-intronENST00000593411ENST00000462314MYO9Bchr19

17322566

+KIAA1211Lchr2

99438918

-

Top

FusionProtFeatures for MYO9B_KIAA1211L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO9B

Q13459

KIAA1211L

Q6NV74

Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.Binds actin with high affinity both in the absence and presence ofATP and its mechanochemical activity is inhibited by calcium ions(PubMed:9490638). Also acts as a GTPase activator for RHOA(PubMed:9490638, PubMed:26529257). Plays a role in the regulationof cell migration via its role as RHOA GTPase activator. This isregulated by its interaction with the SLIT2 receptor ROBO1;interaction with ROBO1 impairs interaction with RHOA andsubsequent activation of RHOA GTPase activity, and thereby leadsto increased levels of active, GTP-bound RHOA (PubMed:26529257).{ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MYO9B_KIAA1211L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MYO9B_KIAA1211L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MYO9B_KIAA1211L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MYO9B_KIAA1211L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYO9BC0036341Schizophrenia3PSYGENET