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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 232

FusionGeneSummary for ABI1_BIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABI1_BIN2
Fusion gene ID: 232
HgeneTgene
Gene symbol

ABI1

BIN2

Gene ID

10006

51411

Gene nameabl interactor 1bridging integrator 2
SynonymsABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1BRAP-1
Cytomap

10p12.1

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionabl interactor 1Abelson interactor 1Abl-interactor protein 1 longabl-binding protein 4eps8 SH3 domain-binding proteininteractor protein AblBP4nap1 binding proteinspectrin SH3 domain-binding protein 1bridging integrator 2breast cancer associated protein BRAP1breast cancer-associated protein 1
Modification date2018052220180523
UniProtAcc

Q8IZP0

Q9UBW5

Ensembl transtripts involved in fusion geneENST00000376170, ENST00000359188, 
ENST00000376142, ENST00000376139, 
ENST00000376160, ENST00000376166, 
ENST00000376138, ENST00000355394, 
ENST00000490841, ENST00000376137, 
ENST00000346832, ENST00000536334, 
ENST00000376134, ENST00000376140, 
ENST00000473481, 		ENST00000604560, 
ENST00000452142, ENST00000267012, 
ENST00000544402, ENST00000603260, 
Fusion gene scores* DoF score7 X 5 X 5=1754 X 4 X 2=32
# samples 84
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ABI1 [Title/Abstract] AND BIN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABI1

GO:0018108

peptidyl-tyrosine phosphorylation

17101133

TgeneBIN2

GO:0097320

plasma membrane tubulation

23285027


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI024013ABI1chr10

27043418

-BIN2chr12

51674854

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000376170ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376170ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376170ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376170ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376170ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000359188ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000359188ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000359188ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000359188ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000359188ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376142ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376142ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376142ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376142ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376142ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376139ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376139ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376139ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376139ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376139ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376160ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376160ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376160ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376160ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376160ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376166ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376166ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376166ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376166ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376166ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376138ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376138ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376138ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376138ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376138ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000355394ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000355394ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000355394ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000355394ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000355394ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000490841ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000490841ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000490841ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000490841ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000490841ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376137ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376137ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376137ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376137ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376137ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000346832ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000346832ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000346832ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000346832ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000346832ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000536334ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000536334ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000536334ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000536334ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000536334ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376134ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376134ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376134ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376134ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376134ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376140ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376140ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376140ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376140ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376140ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000473481ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000473481ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000473481ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000473481ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000473481ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+

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FusionProtFeatures for ABI1_BIN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABI1

Q8IZP0

BIN2

Q9UBW5

Promotes cell motility and migration, probably via itsinteraction with the cell membrane and with podosome proteins thatmediate interaction with the cytoskeleton. Modulates membranecurvature and mediates membrane tubulation. Plays a role inpodosome formation. Inhibits phagocytosis.{ECO:0000269|PubMed:23285027}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABI1_BIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABI1_BIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABI1_BIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ABI1_BIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource