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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23197

FusionGeneSummary for MYO9A_HEXA

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO9A_HEXA
Fusion gene ID: 23197
HgeneTgene
Gene symbol

MYO9A

HEXA

Gene ID

4649

3073

Gene namemyosin IXAhexosaminidase subunit alpha
Synonyms-TSD
Cytomap

15q23

15q23

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IXamyosin-IXaunconventional myosin-9abeta-hexosaminidase subunit alphaN-acetyl-beta-glucosaminidase subunit alphabeta-N-acetylhexosaminidase subunit alphahexosaminidase A (alpha polypeptide)hexosaminidase subunit A
Modification date2018051920180519
UniProtAcc

B2RTY4

P06865

Ensembl transtripts involved in fusion geneENST00000356056, ENST00000444904, 
ENST00000424560, ENST00000564571, 
ENST00000566885, ENST00000563542, 
ENST00000268097, ENST00000566304, 
ENST00000457859, ENST00000567159, 
ENST00000429918, ENST00000567213, 
Fusion gene scores* DoF score7 X 5 X 5=1753 X 4 X 2=24
# samples 94
** MAII scorelog2(9/175*10)=-0.959358015502654
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYO9A [Title/Abstract] AND HEXA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHEXA

GO:0006024

glycosaminoglycan biosynthetic process

25645918


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-LL-A5YP-01AMYO9Achr15

72410021

-HEXAchr15

72648958

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000356056ENST00000268097MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000356056ENST00000566304MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000356056ENST00000457859MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000356056ENST00000567159MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000356056ENST00000429918MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-intronENST00000356056ENST00000567213MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000444904ENST00000268097MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000444904ENST00000566304MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000444904ENST00000457859MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000444904ENST00000567159MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000444904ENST00000429918MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-intronENST00000444904ENST00000567213MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000424560ENST00000268097MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000424560ENST00000566304MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000424560ENST00000457859MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000424560ENST00000567159MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000424560ENST00000429918MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-intronENST00000424560ENST00000567213MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000564571ENST00000268097MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000564571ENST00000566304MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000564571ENST00000457859MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000564571ENST00000567159MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000564571ENST00000429918MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-intronENST00000564571ENST00000567213MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000566885ENST00000268097MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-3CDSENST00000566885ENST00000566304MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000566885ENST00000457859MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000566885ENST00000567159MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-5UTRENST00000566885ENST00000429918MYO9Achr15

72410021

-HEXAchr15

72648958

-
5UTR-intronENST00000566885ENST00000567213MYO9Achr15

72410021

-HEXAchr15

72648958

-
intron-3CDSENST00000563542ENST00000268097MYO9Achr15

72410021

-HEXAchr15

72648958

-
intron-3CDSENST00000563542ENST00000566304MYO9Achr15

72410021

-HEXAchr15

72648958

-
intron-5UTRENST00000563542ENST00000457859MYO9Achr15

72410021

-HEXAchr15

72648958

-
intron-5UTRENST00000563542ENST00000567159MYO9Achr15

72410021

-HEXAchr15

72648958

-
intron-5UTRENST00000563542ENST00000429918MYO9Achr15

72410021

-HEXAchr15

72648958

-
intron-intronENST00000563542ENST00000567213MYO9Achr15

72410021

-HEXAchr15

72648958

-

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FusionProtFeatures for MYO9A_HEXA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO9A

B2RTY4

HEXA

P06865

Responsible for the degradation of GM2 gangliosides, anda variety of other molecules containing terminal N-acetylhexosamines, in the brain and other tissues. The form B is activeagainst certain oligosaccharides. The form S has no measurableactivity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYO9A_HEXA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYO9A_HEXA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYO9APOLR2M, CDC42, MYC, PPP2R2B, MOV10, NXF1, JADE2, SKAP1, CEP152, PCM1, MCM2, EGFR, DQX1, CDC16, LZTS2, TMOD4, NCAPH2, AK9, BPNT1, CRYL1, P4HA2, CASC1, MTNR1AHEXAUSP22, GM2A, H2AFX, FBXO6, ACAT2, AHCY, C9orf78, CAPZB, EZR, GTF3C4, H2AFV, HERC4, FKBP9, GDI1, HIST1H2BO, UBA6, HK1, KTN1, NUBP2, PCNA, PDCD10, RAD23A, UBR7, WDR61, XPNPEP1, STIM2, HNRNPD, SYNCRIP, FAN1, SGTB, CEP170P1, BAG6, DHRS4, TERF2, HEXB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYO9A_HEXA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYO9A_HEXA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHEXAC0039373Tay-Sachs Disease22CTD_human;UNIPROT
TgeneHEXAC3714756Intellectual Disability1CTD_human