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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23196

FusionGeneSummary for MYO9A_GRB2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO9A_GRB2
Fusion gene ID: 23196
HgeneTgene
Gene symbol

MYO9A

GRB2

Gene ID

4649

2885

Gene namemyosin IXAgrowth factor receptor bound protein 2
Synonyms-ASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2
Cytomap

15q23

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IXamyosin-IXaunconventional myosin-9agrowth factor receptor-bound protein 2HT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2growth factor receptor-bound protein 3protein Ash
Modification date2018051920180527
UniProtAcc

B2RTY4

P62993

Ensembl transtripts involved in fusion geneENST00000356056, ENST00000444904, 
ENST00000424560, ENST00000564571, 
ENST00000566885, ENST00000563542, 
ENST00000392562, ENST00000316804, 
ENST00000316615, ENST00000392563, 
ENST00000392564, ENST00000578961, 
ENST00000462266, 
Fusion gene scores* DoF score7 X 5 X 5=1756 X 4 X 4=96
# samples 96
** MAII scorelog2(9/175*10)=-0.959358015502654
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO9A [Title/Abstract] AND GRB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-EY-A210-01AMYO9Achr15

72410021

-GRB2chr17

73328878

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000356056ENST00000392562MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000356056ENST00000316804MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000356056ENST00000316615MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000356056ENST00000392563MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000356056ENST00000392564MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000356056ENST00000578961MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-intronENST00000356056ENST00000462266MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000444904ENST00000392562MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000444904ENST00000316804MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000444904ENST00000316615MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000444904ENST00000392563MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000444904ENST00000392564MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000444904ENST00000578961MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-intronENST00000444904ENST00000462266MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000424560ENST00000392562MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000424560ENST00000316804MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000424560ENST00000316615MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000424560ENST00000392563MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000424560ENST00000392564MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000424560ENST00000578961MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-intronENST00000424560ENST00000462266MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000564571ENST00000392562MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000564571ENST00000316804MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000564571ENST00000316615MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000564571ENST00000392563MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000564571ENST00000392564MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000564571ENST00000578961MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-intronENST00000564571ENST00000462266MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000566885ENST00000392562MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000566885ENST00000316804MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000566885ENST00000316615MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000566885ENST00000392563MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000566885ENST00000392564MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-3CDSENST00000566885ENST00000578961MYO9Achr15

72410021

-GRB2chr17

73328878

-
5UTR-intronENST00000566885ENST00000462266MYO9Achr15

72410021

-GRB2chr17

73328878

-
intron-3CDSENST00000563542ENST00000392562MYO9Achr15

72410021

-GRB2chr17

73328878

-
intron-3CDSENST00000563542ENST00000316804MYO9Achr15

72410021

-GRB2chr17

73328878

-
intron-3CDSENST00000563542ENST00000316615MYO9Achr15

72410021

-GRB2chr17

73328878

-
intron-3CDSENST00000563542ENST00000392563MYO9Achr15

72410021

-GRB2chr17

73328878

-
intron-3CDSENST00000563542ENST00000392564MYO9Achr15

72410021

-GRB2chr17

73328878

-
intron-3CDSENST00000563542ENST00000578961MYO9Achr15

72410021

-GRB2chr17

73328878

-
intron-intronENST00000563542ENST00000462266MYO9Achr15

72410021

-GRB2chr17

73328878

-

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FusionProtFeatures for MYO9A_GRB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO9A

B2RTY4

GRB2

P62993

Adapter protein that provides a critical link betweencell surface growth factor receptors and the Ras signalingpathway. Isoform 2 does not bind to phosphorylated epidermalgrowth factor receptor (EGFR) but inhibits EGF-inducedtransactivation of a RAS-responsive element. Isoform 2 acts as adominant negative protein over GRB2 and by suppressingproliferative signals, may trigger active programmed cell death.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYO9A_GRB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYO9A_GRB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYO9APOLR2M, CDC42, MYC, PPP2R2B, MOV10, NXF1, JADE2, SKAP1, CEP152, PCM1, MCM2, EGFR, DQX1, CDC16, LZTS2, TMOD4, NCAPH2, AK9, BPNT1, CRYL1, P4HA2, CASC1, MTNR1AGRB2CSF1R, PRRC2A, EGFR, ERBB2, ERBB3, ERBB4, MED28, BCR, GAB2, CBL, ETV6, LY6G6F, NEU3, SRC, PDE6G, DOCK1, FASLG, SHC1, SOS1, VAV2, VAV3, RACGAP1, IQGAP1, KRT7, KRT8, KRT17, KRT18, PLEC, EPPK1, BCAR1, WAS, MAP4K1, BLNK, IL2RB, SYN1, PDGFRB, KHDRBS1, PTPN6, PTPN11, SYK, CD22, GAB1, IRS1, TNFRSF1A, PTK2, SH3BP2, CD28, TNK2, KIT, SOCS1, PTPRA, CBLB, EPHA2, AXL, DAG1, MAP2, PLCG1, MST1R, ITGA2B, NCKIPSD, NTRK1, PTPN1, JAK2, GRB2, USP8, CSF3R, HTT, MET, LCP2, SNTA1, ABL1, LAT, FLT4, PIK3R1, FRS2, GAB3, VAV1, SH2B2, SH2B1, PRKAR1A, DCTN1, RET, CRK, PTPN22, JAK1, ARHGAP17, SHB, REPS2, OCRL, PDGFRA, PXN, PAG1, TRAT1, INSR, RAPGEF1, KDR, SELL, ADRB2, EPOR, SYNCRIP, ZAP70, IRS4, MUC1, ITK, LAT2, SH2B3, ANXA2, ARHGAP35, RASA1, PTPN12, CRKL, ADAM15, ADAM10, WASL, EPS15, IL6ST, SH3KBP1, EPHB1, MAP3K1, FLT3, RALGPS1, USP6NL, SPRY2, PTPRE, DNM1, HNRNPC, MAPK9, DRD3, CDKN1B, ALOX5, PIK3C2B, GHR, HCLS1, DTX1, LAX1, SOS2, DRD4, PTK2B, SKAP1, TOM1L1, SHKBP1, FGFR3, INPP5D, MICAL1, PLXNB1, OTUD5, STAMBP, ALK, NPM1, BTK, CSN2, DAB2, EP300, HNRNPK, HSPA5, MAP1A, ATP8, ND4, MYH9, MYH11, NCL, NFYB, PIK3R2, RBBP6, SLC1A2, SPTBN1, SS18, UBA52, UBC, WIPF1, MAP4K3, ASAP2, SYNJ2, DLGAP1, ARHGAP32, HELZ, PDCD6IP, HIPK3, DCTN2, TCERG1, KIF3A, MAP4K5, KIAA1549L, ABI3BP, PTPN23, ASAP1, ERRFI1, WDR44, USP53, RIF1, SH2D4A, GAREM, RBM33, MSI2, WIPF2, SH3D19, NAP1L5, STK32C, MYO18A, A2M, AEBP1, AGT, AHSG, ALAS2, STRADB, AMBP, APCS, APOH, SNRNP200, B2M, GPANK1, BPGM, CLU, DNAJA3, DNAJB11, ESD, FABP1, FHOD1, FN1, GC, H1F0, HP, IK, PBXIP1, POLR2A, PRKAB1, RNF10, TF, TFG, TSC2, ENO1, ITIH4, AP4S1, CUTA, POMP, C21orf58, CD164, C21orf91, CFH, COX6A1, ECHS1, FH, NADK, FTL, PRAP1, GSTK1, TCEAL8, POLR1D, RBP4, SHBG, WDR1, IRF5, PPP3CA, GIT1, CDC42, CASP2, ELAVL1, SYNM, AP2A2, DNM2, NCK1, UBASH3B, CUL3, DCUN1D1, LRRK1, INPPL1, ARAP1, KRT85, HSPA8, HSPG2, KRT86, KRT1, KRT81, KRT35, CAD, KRT10, KRT2, HSPA9, KRT83, CCT8, KRT9, KRT33B, HSP90AA1, DNM3, DYNC1H1, TUBB, KRT34, RPS19, HSPA1B, HSP90AB1, SKAP2, CCT4, EEF1A1P5, KRT6A, KRT14, TUBB4B, TUBA1C, KRT16, TCP1, CCT2, ACTB, FAM175B, CCT3, KRT5, KRT15, CLPX, EEF1G, PSMD11, CALM3, HSPA1L, KRT32, DARS, HSPD1, EEF1D, CNOT1, UBR4, AHNAK, CLTC, KRT36, KRT82, MFAP4, PSTPIP2, PSMC2, PSME1, PSMD14, CD2AP, FUS, BRE, KRT19, CTTN, KRT4, VASP, CCT7, KRT73, HNRNPU, BABAM1, HNRNPD, DRG1, IMPDH2, SERBP1, PIK3CA, TUBA4B, BRCC3, DOK3, HIST4H4, GAPDH, RUVBL1, PSMD13, RPS20, ACTL6A, RARS, CCT5, HSD17B4, TSG101, IRS2, PDE4D, SPRY1, SPRY4, VCAM1, ELMO2, WDR6, WDR77, SNX18, NISCH, YWHAZ, STARD10, YWHAE, SH3PXD2B, DOCK4, PEAK1, PIK3CB, SLC25A5, YWHAB, YWHAQ, PPP2R2A, SIRPA, SYNJ1, FGD6, PIK3AP1, KIRREL, YWHAG, GAREML, AGER, WIPF3, PTPN18, SLC25A13, CYFIP2, ARHGEF7, PPP1CA, CSK, PTPRJ, YWHAH, CSRP1, SH3PXD2A, TTYH2, PIK3R3, FLNA, ARHGAP12, RADIL, SH2D5, FAU, NCKAP1, DIAPH1, HGS, CLASP2, TEC, SLC25A6, HUNK, MLLT4, C1orf27, PPP1CC, HDGFRP3, SLAIN2, EPS15L1, IGF2BP1, PPP5C, GJA9, TAB1, ITGA4, BAG3, CKS2, FTH1, COPB1, PHACTR4, SF3B4, VIM, UBA1, PHC2, KPNA2, CTAGE5, PON2, ARHGEF5, CASC3, MLXIPL, WBP11, YLPM1, SHANK3, NKD2, SLX1A, ACTG1, CBR1, AP2A1, AP2B1, AP2M1, AP2S1, HIST1H3A, SMU1, SNRPD2, CD59, ABL2, AES, EPS8, LMO2, REL, TRIM27, TP53BP2, DDX17, IKZF3, ZBTB7B, ABI3, NUTM2F, DPPA4, HOMEZ, NIF3L1, ARHGAP9, LZTS2, LNX1, C1orf94, PNMA5, PRR22, INCA1, DOK1, FKBP2, FABP5, ITCH, ROS1, HEXB, ACAP1, PLEKHS1, AUNIP, UQCC2, CRBN, LMX1A, MYOZ1, PACRGL, PARD6A, PCDHB5, PPARA, RB1, SOCS4, TMEM128, TSPAN2, VCP, WDFY3, DBN1, E2F2, ARL6IP4, OLIG1, WBSCR27, ZMAT1, CLNK, CEP170, FBF1, MCM2, USP12, GFAP, NEFH, HNRNPA2B1, RPS27A, LGALS3BP, MYL12A, MYL12B, S100A8, S100A9, ESRRB, LIME1, KRAS, LTK, SHC2, SHC4, DUSP13, DUSP8, CYLD, VPS37B, NKX2-5, SPATA2L, MVB12A, ZMYM6, VPS28, DOCK5, THEMIS, RAC1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYO9A_GRB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYO9A_GRB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGRB2C0036341Schizophrenia2PSYGENET