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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2315

FusionGeneSummary for ARF1_DCAF5

check button Fusion gene summary
Fusion gene informationFusion gene name: ARF1_DCAF5
Fusion gene ID: 2315
HgeneTgene
Gene symbol

ARF1

DCAF5

Gene ID

375

8816

Gene nameADP ribosylation factor 1DDB1 and CUL4 associated factor 5
Synonyms-BCRG2|BCRP2|D14S1461E|WDR22
Cytomap

1q42.13

14q24.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor 1DDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2
Modification date2018052720180519
UniProtAcc

P84077

Q96JK2

Ensembl transtripts involved in fusion geneENST00000272102, ENST00000540651, 
ENST00000478424, ENST00000541182, 
ENST00000341516, ENST00000554215, 
ENST00000556847, ENST00000557386, 
ENST00000389997, ENST00000553293, 
Fusion gene scores* DoF score5 X 6 X 2=608 X 7 X 6=336
# samples 69
** MAII scorelog2(6/60*10)=0log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARF1 [Title/Abstract] AND DCAF5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W94277ARF1chr1

228286629

-DCAF5chr14

69518853

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000272102ENST00000341516ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-3UTRENST00000272102ENST00000554215ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000272102ENST00000556847ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000272102ENST00000557386ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000272102ENST00000389997ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000272102ENST00000553293ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-3UTRENST00000540651ENST00000341516ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-3UTRENST00000540651ENST00000554215ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000540651ENST00000556847ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000540651ENST00000557386ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000540651ENST00000389997ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000540651ENST00000553293ARF1chr1

228286629

-DCAF5chr14

69518853

+
intron-3UTRENST00000478424ENST00000341516ARF1chr1

228286629

-DCAF5chr14

69518853

+
intron-3UTRENST00000478424ENST00000554215ARF1chr1

228286629

-DCAF5chr14

69518853

+
intron-intronENST00000478424ENST00000556847ARF1chr1

228286629

-DCAF5chr14

69518853

+
intron-intronENST00000478424ENST00000557386ARF1chr1

228286629

-DCAF5chr14

69518853

+
intron-intronENST00000478424ENST00000389997ARF1chr1

228286629

-DCAF5chr14

69518853

+
intron-intronENST00000478424ENST00000553293ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-3UTRENST00000541182ENST00000341516ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-3UTRENST00000541182ENST00000554215ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000541182ENST00000556847ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000541182ENST00000557386ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000541182ENST00000389997ARF1chr1

228286629

-DCAF5chr14

69518853

+
3UTR-intronENST00000541182ENST00000553293ARF1chr1

228286629

-DCAF5chr14

69518853

+

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FusionProtFeatures for ARF1_DCAF5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARF1

P84077

DCAF5

Q96JK2

GTP-binding protein that functions as an allostericactivator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking amongdifferent compartments. Modulates vesicle budding and uncoatingwithin the Golgi complex. Deactivation induces the redistributionof the entire Golgi complex to the endoplasmic reticulum,suggesting a crucial role in protein trafficking. In its GTP-boundform, its triggers the association with coat proteins with theGolgi membrane. The hydrolysis of ARF1-bound GTP, which ismediated by ARFGAPs proteins, is required for dissociation of coatproteins from Golgi membranes and vesicles. The GTP-bound forminteracts with PICK1 to limit PICK1-mediated inhibition of Arp2/3complex activity; the function is linked to AMPA receptor (AMPAR)trafficking, regulation of synaptic plasicity of excitatorysynapses and spine shrinkage during long-term depression (LTD). May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367,ECO:0000269|PubMed:16964240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARF1_DCAF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARF1_DCAF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARF1_DCAF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneARF1P84077DB09462GlycerinADP-ribosylation factor 1small moleculeapproved|investigational

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RelatedDiseases for ARF1_DCAF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource