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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23136

FusionGeneSummary for MYO1D_MSRA

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1D_MSRA
Fusion gene ID: 23136
HgeneTgene
Gene symbol

MYO1D

MSRA

Gene ID

4642

4482

Gene namemyosin IDmethionine sulfoxide reductase A
SynonymsPPP1R108|myr4PMSR
Cytomap

17q11.2

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-Idmyosin-I gammaprotein phosphatase 1, regulatory subunit 108mitochondrial peptide methionine sulfoxide reductasecytosolic methionine-S-sulfoxide reductasepeptide Met(O) reductasepeptide met (O) reductasepeptide-methionine (S)-S-oxide reductase
Modification date2018051920180519
UniProtAcc

O94832

Q9UJ68

Ensembl transtripts involved in fusion geneENST00000318217, ENST00000394649, 
ENST00000579584, ENST00000584232, 
ENST00000583621, 
ENST00000317173, 
ENST00000441698, ENST00000518255, 
ENST00000521209, ENST00000528246, 
ENST00000382490, ENST00000517594, 
Fusion gene scores* DoF score13 X 7 X 8=7284 X 4 X 3=48
# samples 166
** MAII scorelog2(16/728*10)=-2.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYO1D [Title/Abstract] AND MSRA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYO1D

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW974960MYO1Dchr17

31184346

+MSRAchr8

10151442

-
ChiTaRS3.1AA654941MYO1Dchr17

31184346

+MSRAchr8

10151442

-
ChiTaRS3.1AA654208MYO1Dchr17

31184346

+MSRAchr8

10151442

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000318217ENST00000317173MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000318217ENST00000441698MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000318217ENST00000518255MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000318217ENST00000521209MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000318217ENST00000528246MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000318217ENST00000382490MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000318217ENST00000517594MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000394649ENST00000317173MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000394649ENST00000441698MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000394649ENST00000518255MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000394649ENST00000521209MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000394649ENST00000528246MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000394649ENST00000382490MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000394649ENST00000517594MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000579584ENST00000317173MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000579584ENST00000441698MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000579584ENST00000518255MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000579584ENST00000521209MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000579584ENST00000528246MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000579584ENST00000382490MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000579584ENST00000517594MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000584232ENST00000317173MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000584232ENST00000441698MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000584232ENST00000518255MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000584232ENST00000521209MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000584232ENST00000528246MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000584232ENST00000382490MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000584232ENST00000517594MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000583621ENST00000317173MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000583621ENST00000441698MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000583621ENST00000518255MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000583621ENST00000521209MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000583621ENST00000528246MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000583621ENST00000382490MYO1Dchr17

31184346

+MSRAchr8

10151442

-
intron-intronENST00000583621ENST00000517594MYO1Dchr17

31184346

+MSRAchr8

10151442

-

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FusionProtFeatures for MYO1D_MSRA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO1D

O94832

MSRA

Q9UJ68

Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.Their highly divergent tails are presumed to bind to membranouscompartments, which would be moved relative to actin filaments (Bysimilarity). {ECO:0000250}. Has an important function as a repair enzyme forproteins that have been inactivated by oxidation. Catalyzes thereversible oxidation-reduction of methionine sulfoxide in proteinsto methionine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYO1D_MSRA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYO1D_MSRA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYO1D_MSRA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYO1D_MSRA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYO1DC0004352Autistic Disorder1CTD_human
TgeneMSRAC0036341Schizophrenia2PSYGENET
TgeneMSRAC0236969Substance-Related Disorders1CTD_human