FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23122

FusionGeneSummary for MYO1B_ITGAV

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1B_ITGAV
Fusion gene ID: 23122
HgeneTgene
Gene symbol

MYO1B

ITGAV

Gene ID

4430

3685

Gene namemyosin IBintegrin subunit alpha V
SynonymsMMI-alpha|MMIa|MYH-1c|myr1CD51|MSK8|VNRA|VTNR
Cytomap

2q32.3

2q32.1

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IbMYO1B variant proteinmyosin-I alphaintegrin alpha-Vantigen identified by monoclonal antibody L230integrin alphaVbeta3integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)vitronectin receptor subunit alpha
Modification date2018052220180520
UniProtAcc

O43795

P06756

Ensembl transtripts involved in fusion geneENST00000339514, ENST00000392318, 
ENST00000304164, ENST00000392316, 
ENST00000439065, ENST00000496992, 
ENST00000261023, ENST00000374907, 
ENST00000433736, ENST00000474571, 
Fusion gene scores* DoF score10 X 9 X 5=4504 X 4 X 3=48
# samples 104
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO1B [Title/Abstract] AND ITGAV [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneITGAV

GO:0007155

cell adhesion

10218736

TgeneITGAV

GO:0008284

positive regulation of cell proliferation

19578119

TgeneITGAV

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

TgeneITGAV

GO:0034446

substrate adhesion-dependent cell spreading

24658351

TgeneITGAV

GO:0045785

positive regulation of cell adhesion

10708943

TgeneITGAV

GO:0050764

regulation of phagocytosis

10570297

TgeneITGAV

GO:0070588

calcium ion transmembrane transport

18395422

TgeneITGAV

GO:2000536

negative regulation of entry of bacterium into host cell

10570297


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-UB-A7MA-01AMYO1Bchr2

192110337

+ITGAVchr2

187487066

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000339514ENST00000261023MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-3CDSENST00000339514ENST00000374907MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-3CDSENST00000339514ENST00000433736MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-intronENST00000339514ENST00000474571MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-3CDSENST00000392318ENST00000261023MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-3CDSENST00000392318ENST00000374907MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-3CDSENST00000392318ENST00000433736MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-intronENST00000392318ENST00000474571MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-3CDSENST00000304164ENST00000261023MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-3CDSENST00000304164ENST00000374907MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-3CDSENST00000304164ENST00000433736MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
5UTR-intronENST00000304164ENST00000474571MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000392316ENST00000261023MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000392316ENST00000374907MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000392316ENST00000433736MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-intronENST00000392316ENST00000474571MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000439065ENST00000261023MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000439065ENST00000374907MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000439065ENST00000433736MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-intronENST00000439065ENST00000474571MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000496992ENST00000261023MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000496992ENST00000374907MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-3CDSENST00000496992ENST00000433736MYO1Bchr2

192110337

+ITGAVchr2

187487066

+
intron-intronENST00000496992ENST00000474571MYO1Bchr2

192110337

+ITGAVchr2

187487066

+

Top

FusionProtFeatures for MYO1B_ITGAV


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO1B

O43795

ITGAV

P06756

Motor protein that may participate in process criticalto neuronal development and function such as cell migration,neurite outgrowth and vesicular transport. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MYO1B_ITGAV


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MYO1B_ITGAV


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYO1BEIF4A2, BRF2, MYC, SIRT7, TCF3, SP1, FBXO25, KIAA0368, CUL1, LRRK2, ATP6V1B1, ESR1, PAN2, RPA3, RPA2, RPA1, CUL7, CCDC8, EGFR, CSNK2A1, DAPK1, NTRK1, PTEN, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZNF746, CDH1, STYXL1, NEXN, BCL7C, BCL7A, AVIL, LSP1, CDH5, DKK3, CYLD, DLST, PDHA1ITGAVNOV, ILK, ITGB3, AUP1, L1CAM, CYR61, PLP1, MMP2, CSF1R, CBL, BCAR1, PHKA2, PXN, FBXO6, MCAT, KRT3, FN1, THBS1, EPHA2, TAZ, SUSD4, DPEP2, NTRK1, ITGB1, PSMD12, SPP1, LGALS3BP, FBXW7, MAPK3, NCOR1, NCOR2, EP300, MAPK1, STAT1, SHC1, PTK2, PLA2G2A, ADAM9, ERBB2, ANGPT2, NCL, PAK4, TNFSF13B, LYZL2, NAAA, DEFA1, ST3GAL1, GGH, TMEM25, ST8SIA4, TCTN2, INSL5, FCGR3B, EDIL3, FUT8, PTCH1, B3GNT2, UBC, ITGA4, ITGAV, ITGB5, AGMAT, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MYO1B_ITGAV


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneITGAVP06756DB00098Antithymocyte immunoglobulin (rabbit)Integrin alpha-Vbiotechapproved

Top

RelatedDiseases for MYO1B_ITGAV


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYO1BC0043094Weight Gain1CTD_human
TgeneITGAVC0038454Cerebrovascular accident1CTD_human
TgeneITGAVC2937358Cerebral Hemorrhage1CTD_human