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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23121

FusionGeneSummary for MYO1B_GLS

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1B_GLS
Fusion gene ID: 23121
HgeneTgene
Gene symbol

MYO1B

GLS

Gene ID

4430

27165

Gene namemyosin IBglutaminase 2
SynonymsMMI-alpha|MMIa|MYH-1c|myr1GA|GLS|LGA|hLGA
Cytomap

2q32.3

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IbMYO1B variant proteinmyosin-I alphaglutaminase liver isoform, mitochondrialL-glutamine amidohydrolasebreast cell glutaminaseglutaminase 2 (liver, mitochondrial)glutaminase Iphosphate-activated glutaminasephosphate-dependent glutaminase
Modification date2018052220180523
UniProtAcc

O43795

O94925

Ensembl transtripts involved in fusion geneENST00000339514, ENST00000392318, 
ENST00000304164, ENST00000392316, 
ENST00000439065, ENST00000496992, 
ENST00000320717, ENST00000338435, 
ENST00000409626, ENST00000409428, 
ENST00000409215, ENST00000471443, 
Fusion gene scores* DoF score10 X 9 X 5=4508 X 7 X 3=168
# samples 108
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO1B [Title/Abstract] AND GLS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-G2-A2ES-01AMYO1Bchr2

192290042

+GLSchr2

191759878

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000339514ENST00000320717MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-3CDSENST00000339514ENST00000338435MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000339514ENST00000409626MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000339514ENST00000409428MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000339514ENST00000409215MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000339514ENST00000471443MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-3CDSENST00000392318ENST00000320717MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-3CDSENST00000392318ENST00000338435MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000392318ENST00000409626MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000392318ENST00000409428MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000392318ENST00000409215MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000392318ENST00000471443MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-3CDSENST00000304164ENST00000320717MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-3CDSENST00000304164ENST00000338435MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000304164ENST00000409626MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000304164ENST00000409428MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000304164ENST00000409215MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000304164ENST00000471443MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-3CDSENST00000392316ENST00000320717MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-3CDSENST00000392316ENST00000338435MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000392316ENST00000409626MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000392316ENST00000409428MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000392316ENST00000409215MYO1Bchr2

192290042

+GLSchr2

191759878

+
3UTR-intronENST00000392316ENST00000471443MYO1Bchr2

192290042

+GLSchr2

191759878

+
Frame-shiftENST00000439065ENST00000320717MYO1Bchr2

192290042

+GLSchr2

191759878

+
Frame-shiftENST00000439065ENST00000338435MYO1Bchr2

192290042

+GLSchr2

191759878

+
5CDS-intronENST00000439065ENST00000409626MYO1Bchr2

192290042

+GLSchr2

191759878

+
5CDS-intronENST00000439065ENST00000409428MYO1Bchr2

192290042

+GLSchr2

191759878

+
5CDS-intronENST00000439065ENST00000409215MYO1Bchr2

192290042

+GLSchr2

191759878

+
5CDS-intronENST00000439065ENST00000471443MYO1Bchr2

192290042

+GLSchr2

191759878

+
intron-3CDSENST00000496992ENST00000320717MYO1Bchr2

192290042

+GLSchr2

191759878

+
intron-3CDSENST00000496992ENST00000338435MYO1Bchr2

192290042

+GLSchr2

191759878

+
intron-intronENST00000496992ENST00000409626MYO1Bchr2

192290042

+GLSchr2

191759878

+
intron-intronENST00000496992ENST00000409428MYO1Bchr2

192290042

+GLSchr2

191759878

+
intron-intronENST00000496992ENST00000409215MYO1Bchr2

192290042

+GLSchr2

191759878

+
intron-intronENST00000496992ENST00000471443MYO1Bchr2

192290042

+GLSchr2

191759878

+

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FusionProtFeatures for MYO1B_GLS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO1B

O43795

GLS

O94925

Motor protein that may participate in process criticalto neuronal development and function such as cell migration,neurite outgrowth and vesicular transport. {ECO:0000250}. Catalyzes the first reaction in the primary pathway forthe renal catabolism of glutamine. Plays a role in maintainingacid-base homeostasis. Regulates the levels of theneurotransmitter glutamate in the brain. Isoform 2 lacks catalyticactivity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYO1B_GLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYO1B_GLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYO1BEIF4A2, BRF2, MYC, SIRT7, TCF3, SP1, FBXO25, KIAA0368, CUL1, LRRK2, ATP6V1B1, ESR1, PAN2, RPA3, RPA2, RPA1, CUL7, CCDC8, EGFR, CSNK2A1, DAPK1, NTRK1, PTEN, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZNF746, CDH1, STYXL1, NEXN, BCL7C, BCL7A, AVIL, LSP1, CDH5, DKK3, CYLD, DLST, PDHA1GLSSNTA1, CUL5, ATXN10, ATF2, CAPN1, EIF5A, GDA, GNS, MVD, MYL12A, PEPD, MRPL43, METTL20, C21orf33, NUFIP1, MRPL4, PPA2, ATF6B, HMGCL, ETFA, MRM1, RARS2, TNF, OXLD1, UNK, SIRT5, MCM2, SPATA20, COQ9, PTPMT1, CISD3, CCL22, NDUFS7, SNRNP27, CFAP45, TRMT61B, YBEY, OTC, ACAD9, FGB, LAMP3, ATCAY


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYO1B_GLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGLSO94925DB00142Glutamic AcidGlutaminase kidney isoform, mitochondrialsmall moleculeapproved|nutraceutical

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RelatedDiseases for MYO1B_GLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYO1BC0043094Weight Gain1CTD_human
TgeneGLSC0000786Spontaneous abortion1CTD_human
TgeneGLSC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGLSC0029408Degenerative polyarthritis1CTD_human
TgeneGLSC0036341Schizophrenia1PSYGENET