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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23099

FusionGeneSummary for MYO18A_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO18A_BCAS3
Fusion gene ID: 23099
HgeneTgene
Gene symbol

MYO18A

BCAS3

Gene ID

399687

54828

Gene namemyosin XVIIIABCAS3, microtubule associated cell migration factor
SynonymsMAJN|MYSPDZ|SP-R210|SPR210GAOB1|MAAB
Cytomap

17q11.2

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-XVIIIaSP-A receptor subunit SP-R210 alphaSmolecule associated with JAK3 N-terminusmyosin 18Amyosin containing PDZ domainmyosin containing a PDZ domainsurfactant protein receptor SP-R210breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018051920180523
UniProtAcc

Q92614

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000354329, ENST00000529578, 
ENST00000533112, ENST00000531253, 
ENST00000527372, 
ENST00000589222, 
ENST00000407086, ENST00000390652, 
ENST00000408905, ENST00000588462, 
ENST00000585744, ENST00000588874, 
ENST00000585812, 
Fusion gene scores* DoF score18 X 14 X 9=226826 X 15 X 15=5850
# samples 2141
** MAII scorelog2(21/2268*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO18A [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHYMTCGA-ZB-A96L-01AMYO18Achr17

27492960

-BCAS3chr17

58987893

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000354329ENST00000589222MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000354329ENST00000407086MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000354329ENST00000390652MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000354329ENST00000408905MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000354329ENST00000588462MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000354329ENST00000585744MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000354329ENST00000588874MYO18Achr17

27492960

-BCAS3chr17

58987893

+
5CDS-intronENST00000354329ENST00000585812MYO18Achr17

27492960

-BCAS3chr17

58987893

+
intron-3CDSENST00000529578ENST00000589222MYO18Achr17

27492960

-BCAS3chr17

58987893

+
intron-3CDSENST00000529578ENST00000407086MYO18Achr17

27492960

-BCAS3chr17

58987893

+
intron-3CDSENST00000529578ENST00000390652MYO18Achr17

27492960

-BCAS3chr17

58987893

+
intron-3CDSENST00000529578ENST00000408905MYO18Achr17

27492960

-BCAS3chr17

58987893

+
intron-3CDSENST00000529578ENST00000588462MYO18Achr17

27492960

-BCAS3chr17

58987893

+
intron-3CDSENST00000529578ENST00000585744MYO18Achr17

27492960

-BCAS3chr17

58987893

+
intron-3CDSENST00000529578ENST00000588874MYO18Achr17

27492960

-BCAS3chr17

58987893

+
intron-intronENST00000529578ENST00000585812MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000533112ENST00000589222MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000533112ENST00000407086MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000533112ENST00000390652MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000533112ENST00000408905MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000533112ENST00000588462MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000533112ENST00000585744MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000533112ENST00000588874MYO18Achr17

27492960

-BCAS3chr17

58987893

+
5CDS-intronENST00000533112ENST00000585812MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000531253ENST00000589222MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000531253ENST00000407086MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000531253ENST00000390652MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000531253ENST00000408905MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000531253ENST00000588462MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000531253ENST00000585744MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000531253ENST00000588874MYO18Achr17

27492960

-BCAS3chr17

58987893

+
5CDS-intronENST00000531253ENST00000585812MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000527372ENST00000589222MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000527372ENST00000407086MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000527372ENST00000390652MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000527372ENST00000408905MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000527372ENST00000588462MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000527372ENST00000585744MYO18Achr17

27492960

-BCAS3chr17

58987893

+
Frame-shitENST00000527372ENST00000588874MYO18Achr17

27492960

-BCAS3chr17

58987893

+
5CDS-intronENST00000527372ENST00000585812MYO18Achr17

27492960

-BCAS3chr17

58987893

+

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FusionProtFeatures for MYO18A_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO18A

Q92614

BCAS3

Q9H6U6

May link Golgi membranes to the cytoskeleton andparticipate in the tensile force required for vesicle budding fromthe Golgi. Thereby, may play a role in Golgi membrane traffickingand could indirectly give its flattened shape to the Golgiapparatus (PubMed:19837035, PubMed:23345592). Alternatively, inconcert with LURAP1 and CDC42BPA/CDC42BPB, has been involved inmodulating lamellar actomyosin retrograde flow that is crucial tocell protrusion and migration (PubMed:18854160). May be involvedin the maintenance of the stromal cell architectures required forcell to cell contact (By similarity). Regulates trafficking,expression, and activation of innate immune receptors onmacrophages. Plays a role to suppress inflammatory responsivenessof macrophages via a mechanism that modulates CD14 trafficking(PubMed:25965346). Acts as a receptor of surfactant-associatedprotein A (SFTPA1/SP-A) and plays an important role ininternalization and clearance of SFTPA1-opsonized S.aureus byalveolar macrophages (PubMed:16087679, PubMed:21123169). Stronglyenhances natural killer cell cytotoxicity (PubMed:27467939).{ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679,ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035,ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592,ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYO18A_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYO18A_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYO18AGRB2, ARAF, MARK4, CUL4B, ATXN1, PAN2, ENO1, SHMT2, MOV10, NXF1, YIF1B, DDRGK1, LIMS1, LRFN4, PYCR2, UPK3B, RCN1, SEPT1, SP6, CDKL4, FIG4, SLC30A6, SPC25, UQCRB, YEATS4, DDX46, DIEXF, PUF60, SMARCA4, ACTA1, ACTB, ACTG1, ACTN4, AP2A1, ANXA2, DST, CALM1, CAPZA1, CAPZA2, CAPZB, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CSNK1A1, DAB2, DAPK3, DBN1, DSG2, CTTN, FLII, FLNA, FLNB, FYN, GSN, HMGB2, ABLIM1, LMO7, MYO1B, MYH9, MYL6, MYO1C, MYO1E, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, PIK3C2A, PLEC, PPP1CA, PPP1CB, TWF1, RANGAP1, SPTAN1, SPTBN1, SPTBN2, SSFA2, ST5, SVIL, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, TPM4, CORO2A, LUZP1, PICALM, SORBS2, LRRFIP2, TJP2, CDC42BPB, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, BASP1, DCTN2, MYL12A, DSTN, TRIOBP, AKAP2, SYNPO, CEP162, LIMCH1, SIPA1L3, MPRIP, COBL, SPECC1L, FBXO46, CORO1C, CCRN4L, PLEKHG3, RAI14, TES, TMOD3, LIMA1, BMP2K, MYO5C, CORO1B, KIAA1211, CGN, MICAL3, ARHGAP21, AFAP1, INF2, EFHD2, CYBRD1, MYO19, ARPC5L, KCTD10, LZTS2, STON2, SSH2, PHLDB2, NEXN, SPECC1, MISP, MYL6B, PPP1R18, TPRN, DDX51, CDK2, IQGAP1, PLK2, ANLN, GAN, MYL3, RPL15, PATL1, HBZ, NOX4, DLSTBCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYO18A_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYO18A_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource