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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23093

FusionGeneSummary for MYO15B_IGSF5

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO15B_IGSF5
Fusion gene ID: 23093
HgeneTgene
Gene symbol

MYO15B

IGSF5

Gene ID

80022

150084

Gene namemyosin XVBimmunoglobulin superfamily member 5
SynonymsMYO15BPGSF5|JAM4
Cytomap

17q25.1

21q22.2

Type of geneprotein-codingprotein-coding
Descriptionmyosin XVBmyosin XVB pseudogeneunconventional myosin XVBP pseudogeneimmunoglobulin superfamily member 5immunoglobulin superfamily 5 likejunctional adhesion molecule 4
Modification date2018051920180523
UniProtAcc

Q96JP2

Q9NSI5

Ensembl transtripts involved in fusion geneENST00000578382, ENST00000583560, 
ENST00000380588, ENST00000479378, 
Fusion gene scores* DoF score4 X 3 X 4=483 X 2 X 2=12
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYO15B [Title/Abstract] AND IGSF5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5525-01AMYO15Bchr17

73608097

+IGSF5chr21

41163935

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578382ENST00000380588MYO15Bchr17

73608097

+IGSF5chr21

41163935

+
3UTR-intronENST00000578382ENST00000479378MYO15Bchr17

73608097

+IGSF5chr21

41163935

+
intron-3CDSENST00000583560ENST00000380588MYO15Bchr17

73608097

+IGSF5chr21

41163935

+
intron-intronENST00000583560ENST00000479378MYO15Bchr17

73608097

+IGSF5chr21

41163935

+

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FusionProtFeatures for MYO15B_IGSF5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO15B

Q96JP2

IGSF5

Q9NSI5

Unknown, due to the absence of a functional motordomain. Provides, together with MAGI1, an adhesion machinery attight junctions, which may regulate the permeability of kidneyglomerulus and small intestinal epithelial cells. Mediatescalcium-independent homophilic cell adhesion. In testis, it mayfunction as a cell adhesion molecule rather than a tight-junctionprotein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYO15B_IGSF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYO15B_IGSF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYO15BSSSCA1, RAD54B, NADSYN1, GFAP, TRIM29, ZBTB8A, NEDD1, AES, DNAJA3, RUNDC3A, NUP62, PNMA5, FAM9B, CEP57L1, CCDC36, BEND7, SNW1, CDC5LIGSF5MAGI1, LNX1, LNX2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYO15B_IGSF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYO15B_IGSF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIGSF5C0033578Prostatic Neoplasms1CTD_human