|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23086 |
FusionGeneSummary for MYO10_RB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYO10_RB1 | Fusion gene ID: 23086 | Hgene | Tgene | Gene symbol | MYO10 | RB1 | Gene ID | 4651 | 5925 |
| Gene name | myosin X | RB transcriptional corepressor 1 | |
| Synonyms | - | OSRC|PPP1R130|RB|p105-Rb|pRb|pp110 | |
| Cytomap | 5p15.1 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | unconventional myosin-Xunconventional myosin-10unconventionnal myosin-X | retinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9HD67 | P06400 | |
| Ensembl transtripts involved in fusion gene | ENST00000513610, ENST00000507288, ENST00000274203, ENST00000515803, ENST00000427430, ENST00000505695, ENST00000512061, | ENST00000267163, ENST00000484879, | |
| Fusion gene scores | * DoF score | 13 X 10 X 6=780 | 7 X 5 X 5=175 |
| # samples | 15 | 8 | |
| ** MAII score | log2(15/780*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYO10 [Title/Abstract] AND RB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RB1 | GO:0043550 | regulation of lipid kinase activity | 16286473 |
| Tgene | RB1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10783144|12065415|19223331 |
| Tgene | RB1 | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 25100735 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-JV-A5VF-01A | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000513610 | ENST00000267163 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| 5CDS-intron | ENST00000513610 | ENST00000484879 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| intron-3CDS | ENST00000507288 | ENST00000267163 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| intron-intron | ENST00000507288 | ENST00000484879 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| In-frame | ENST00000274203 | ENST00000267163 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| 5CDS-intron | ENST00000274203 | ENST00000484879 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| In-frame | ENST00000515803 | ENST00000267163 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| 5CDS-intron | ENST00000515803 | ENST00000484879 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| Frame-shift | ENST00000427430 | ENST00000267163 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| 5CDS-intron | ENST00000427430 | ENST00000484879 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| Frame-shift | ENST00000505695 | ENST00000267163 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| 5CDS-intron | ENST00000505695 | ENST00000484879 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| intron-3CDS | ENST00000512061 | ENST00000267163 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
| intron-intron | ENST00000512061 | ENST00000484879 | MYO10 | chr5 | 16689933 | - | RB1 | chr13 | 48934153 | + |
Top |
FusionProtFeatures for MYO10_RB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYO10 | RB1 |
| Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.MYO10 binds to actin filaments and actin bundles and functions asplus end-directed motor. The tail domain binds to membranouscompartments containing phosphatidylinositol 3,4,5-trisphosphateor integrins, and mediates cargo transport along actin filaments.Regulates cell shape, cell spreading and cell adhesion. Stimulatesthe formation and elongation of filopodia. May play a role inneurite outgrowth and axon guidance. In hippocampal neurons itinduces the formation of dendritic filopodia by trafficking theactin-remodeling protein VASP to the tips of filopodia, where itpromotes actin elongation. Plays a role in formation of thepodosome belt in osteoclasts. {ECO:0000269|PubMed:16894163,ECO:0000269|PubMed:18570893}. Isoform Headless: Functions as a dominant-negativeregulator of isoform 1, suppressing its filopodia-inducing andaxon outgrowth-promoting activities. In hippocampal neurons, itincreases VASP retention in spine heads to induce spine formationand spine head expansion (By similarity). {ECO:0000250}. | Key regulator of entry into cell division that acts as atumor suppressor. Promotes G0-G1 transition when phosphorylated byCDK3/cyclin-C. Acts as a transcription repressor of E2F1 targetgenes. The underphosphorylated, active form of RB1 interacts withE2F1 and represses its transcription activity, leading to cellcycle arrest. Directly involved in heterochromatin formation bymaintaining overall chromatin structure and, in particular, thatof constitutive heterochromatin by stabilizing histonemethylation. Recruits and targets histone methyltransferasesSUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptionalrepression. Controls histone H4 'Lys-20' trimethylation. Inhibitsthe intrinsic kinase activity of TAF1. Mediates transcriptionalrepression by SMARCA4/BRG1 by recruiting a histone deacetylase(HDAC) complex to the c-FOS promoter. In resting neurons,transcription of the c-FOS promoter is inhibited by BRG1-dependentrecruitment of a phospho-RB1-HDAC1 repressor complex. Upon calciuminflux, RB1 is dephosphorylated by calcineurin, which leads torelease of the repressor complex (By similarity). In case of viralinfections, interactions with SV40 large T antigen, HPV E7 proteinor adenovirus E1A protein induce the disassembly of RB1-E2F1complex thereby disrupting RB1's activity. {ECO:0000250,ECO:0000269|PubMed:15084261}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MYO10_RB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MYO10_ENST00000274203_chr5_16689933_-_RB1_ENST00000267163_chr13_48934153_+_1382aa MPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQK LEKRREEEVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEEKKK QEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTE ASLQKLQERRDQELRRLEEEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDEGFEADDDA FKDSPNPSEHGHSDQRTSGIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHNSSSGESTYCMPQNAGDLPSPDGDYDYDQ DDYEDGAITSGSSVTFSNSYGSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFEDSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLY MKGGLMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNT TKENGIDIIMADRTFHLIAESPEDARGSITNGRXSGDFISVNAMCPXLFYXTLTSHVAQRTIXNSCYTHXWFTSNTQARSEQECTDSKTT RKXYKNYXSSLXRTXMXYRXGEKCLFQKFYTFYEFSWTCNIXWTSRGXKSFXTIRRNLSXKXRSRCKIIFGSXXNSSDXFYRQFXNTENT TKKXPXXRGECNSSTHSSXDCYEHYPTINDDFKFSKXSTFRKSDFLFXQLHSESKRKYTEKSEGYRIHLXREICXSCGTGLCRNWITAIQ TWSSLVLPSNGIHAXIRRRTIIHSKFXQTSEXQHFSYVFIGVRSXGCNGHIXQKYISESXFWNRFVFPMDSECAXFKSLXFLQSDRKFYQ SRRQLDKRNDKTFRTMXTSNHGIPCMALRFTFIXSYXTIKGPRRTNXSPXICLSSXSSSPEXSHCSRYVSFSCKISKEKRFNYACKFYCK CRDTSNLSLPDPEAIEIYLSFTVLXKSVSASLSPAKYTLXTPSVXAPRIRTYHLDPFPAHPAEXVXTHERQAFGPNYDVFHVWHMQSEEY RPXIQNHCNSIQGSSSCCSGDIQTCFDQRRGVXFYYSILXLGLHAETENKYFAVCFHQAPYLVTNTSHSSKPLQVSXFTLTDSWREHLYF TPEESIXNFRRSANTNKNDSKIKNLSINWXIIRDFXEVPENKSDGMXQRPCAQKKCXRKQPSXTTEKTTLXYXRIRXSRWKXTSPRRVQI >In-frame_MYO10_ENST00000515803_chr5_16689933_-_RB1_ENST00000267163_chr13_48934153_+_1364aa MLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKRREEEVSHAAMVIRA HVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERER ERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQELRRLE EEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDEGFEADDDAFKDSPNPSEHGHSDQRTS GIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHNSSSGESTYCMPQNAGDLPSPDGDYDYDQDDYEDGAITSGSSVTFSN SYGSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFEDSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLYMKGGLMNSWKRRWCVLKD ETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNTTKENGIDIIMADRTFHLI AESPEDARGSITNGRXSGDFISVNAMCPXLFYXTLTSHVAQRTIXNSCYTHXWFTSNTQARSEQECTDSKTTRKXYKNYXSSLXRTXMXY RXGEKCLFQKFYTFYEFSWTCNIXWTSRGXKSFXTIRRNLSXKXRSRCKIIFGSXXNSSDXFYRQFXNTENTTKKXPXXRGECNSSTHSS XDCYEHYPTINDDFKFSKXSTFRKSDFLFXQLHSESKRKYTEKSEGYRIHLXREICXSCGTGLCRNWITAIQTWSSLVLPSNGIHAXIRR RTIIHSKFXQTSEXQHFSYVFIGVRSXGCNGHIXQKYISESXFWNRFVFPMDSECAXFKSLXFLQSDRKFYQSRRQLDKRNDKTFRTMXT SNHGIPCMALRFTFIXSYXTIKGPRRTNXSPXICLSSXSSSPEXSHCSRYVSFSCKISKEKRFNYACKFYCKCRDTSNLSLPDPEAIEIY LSFTVLXKSVSASLSPAKYTLXTPSVXAPRIRTYHLDPFPAHPAEXVXTHERQAFGPNYDVFHVWHMQSEEYRPXIQNHCNSIQGSSSCC SGDIQTCFDQRRGVXFYYSILXLGLHAETENKYFAVCFHQAPYLVTNTSHSSKPLQVSXFTLTDSWREHLYFTPEESIXNFRRSANTNKN DSKIKNLSINWXIIRDFXEVPENKSDGMXQRPCAQKKCXRKQPSXTTEKTTLXYXRIRXSRWKXTSPRRVQISAETGRNDFYSNTNAKAE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MYO10_ENST00000274203_chr5_16689933_-_RB1_ENST00000267163_chr13_48934153_+_4147nt ATGCCAGACCAGTTTGACCAGGCGGTTGTGCTGAACCAGCTGCGGTACTCAGGGATGCTGGAGACTGTGAGAATCCGCAAAGCTGGGTAT GCGGTCCGAAGACCCTTTCAGGACTTTTACAAAAGGTATAAAGTGCTGATGAGGAATCTGGCTCTGCCTGAGGACGTCCGAGGGAAGTGC ACGAGCCTGCTGCAGCTCTATGATGCCTCCAACAGCGAGTGGCAGCTGGGGAAGACCAAGGTCTTTCTTCGAGAATCCTTGGAACAGAAA CTGGAGAAGCGGAGGGAAGAGGAAGTGAGCCACGCGGCCATGGTGATTCGGGCCCATGTCTTGGGCTTCTTAGCACGAAAACAATACAGA AAGGTCCTTTATTGTGTGGTGATAATACAGAAGAATTACAGAGCATTCCTTCTGAGGAGGAGATTTTTGCACCTGAAAAAGGCAGCCATA GTTTTCCAGAAGCAACTCAGAGGTCAGATTGCTCGGAGAGTTTACAGACAATTGCTGGCAGAGAAAAGGGAGCAAGAAGAAAAGAAGAAA CAGGAAGAGGAAGAAAAGAAGAAACGGGAGGAAGAAGAAAGAGAAAGAGAGAGAGAGCGAAGAGAAGCCGAGCTCCGCGCCCAGCAGGAA GAAGAAACGAGGAAGCAGCAAGAACTCGAAGCCTTGCAGAAGAGCCAGAAGGAAGCTGAACTGACCCGTGAACTGGAGAAACAGAAGGAA AATAAGCAGGTGGAAGAGATCCTCCGTCTGGAGAAAGAAATCGAGGACCTGCAGCGCATGAAGGAGCAGCAGGAGCTGTCGCTGACCGAG GCTTCCCTGCAGAAGCTGCAGGAGCGGCGGGACCAGGAGCTCCGCAGGCTGGAGGAGGAAGCGTGCAGGGCGGCCCAGGAGTTCCTCGAG TCCCTCAATTTCGACGAGATCGACGAGTGTGTCCGGAATATCGAGCGGTCCCTGTCGGTGGGAAGCGAATTTTCCAGCGAGCTGGCTGAG AGCGCATGCGAGGAGAAGCCCAACTTCAACTTCAGCCAGCCCTACCCAGAGGAGGAGGTCGATGAGGGCTTCGAAGCCGACGACGACGCC TTCAAGGACTCCCCCAACCCCAGCGAGCACGGCCACTCAGACCAGCGAACAAGTGGCATCCGGACCAGCGATGACTCTTCAGAGGAGGAC CCATACATGAACGACACGGTGGTGCCCACCAGCCCCAGTGCGGACAGCACGGTGCTGCTCGCCCCATCAGTGCAGGACTCCGGGAGCCTA CACAACTCCTCCAGCGGCGAGTCCACCTACTGCATGCCCCAGAACGCTGGGGACTTGCCCTCCCCAGACGGCGACTACGACTACGACCAG GATGACTATGAGGACGGTGCCATCACTTCCGGCAGCAGCGTGACCTTCTCCAACTCCTACGGCAGCCAGTGGTCCCCCGACTACCGCTGC TCTGTGGGGACCTACAACAGCTCGGGTGCCTACCGGTTCAGCTCTGAGGGGGCGCAGTCCTCGTTTGAAGATAGTGAAGAGGACTTTGAT TCCAGGTTTGATACAGATGATGAGCTTTCATACCGGCGTGACTCTGTGTACAGCTGTGTCACTCTGCCGTATTTCCACAGCTTTCTGTAC ATGAAAGGTGGCCTGATGAACTCTTGGAAACGCCGCTGGTGCGTCCTCAAGGATGAAACCTTCTTGTGGTTCCGCTCCAAGCAGGAGGCC CTCAAGCAAGGCTGGCTCCACAAAAAAGGGGGGGGCTCCTCCACGCTGTCCAGGAGAAATTGGAAGAAGCGCTGGTTTGTCCTCCGCCAG TCCAAGCTGATGTACTTTGAAAACGACAGCGAGGAGAAGCTCAAGGGCACCGTAGAAGTGCGAACGGCAAAAGAGATCATAGATAACACC ACCAAGGAGAATGGGATCGACATCATTATGGCCGATAGGACTTTCCACCTGATTGCAGAGTCCCCAGAAGATGCCAGGGGAAGTATTACA AATGGAAGATGATCTGGTGATTTCATTTCAGTTAATGCTATGTGTCCTTGACTATTTTATTAAACTCTCACCTCCCATGTTGCTCAAAGA ACCATATAAAACAGCTGTTATACCCATTAATGGTTCACCTCGAACACCCAGGCGAGGTCAGAACAGGAGTGCACGGATAGCAAAACAACT AGAAAATGATACAAGAATTATTGAAGTTCTCTGTAAAGAACATGAATGTAATATAGATGAGGTGAAAAATGTTTATTTCAAAAATTTTAT ACCTTTTATGAATTCTCTTGGACTTGTAACATCTAATGGACTTCCAGAGGTTGAAAATCTTTCTAAACGATACGAAGAAATTTATCTTAA AAATAAAGATCTAGATGCAAGATTATTTTTGGATCATGATAAAACTCTTCAGACTGATTCTATAGACAGTTTTGAAACACAGAGAACACC ACGAAAAAGTAACCTTGATGAAGAGGTGAATGTAATTCCTCCACACACTCCAGTTAGGACTGTTATGAACACTATCCAACAATTAATGAT GATTTTAAATTCAGCAAGTGATCAACCTTCAGAAAATCTGATTTCCTATTTTAACAACTGCACAGTGAATCCAAAAGAAAGTATACTGAA AAGAGTGAAGGATATAGGATACATCTTTAAAGAGAAATTTGCTAAAGCTGTGGGACAGGGTTGTGTCGAAATTGGATCACAGCGATACAA ACTTGGAGTTCGCTTGTATTACCGAGTAATGGAATCCATGCTTAAATCAGAAGAAGAACGATTATCCATTCAAAATTTTAGCAAACTTCT GAATGACAACATTTTTCATATGTCTTTATTGGCGTGCGCTCTTGAGGTTGTAATGGCCACATATAGCAGAAGTACATCTCAGAATCTTGA TTCTGGAACAGATTTGTCTTTCCCATGGATTCTGAATGTGCTTAATTTAAAAGCCTTTGATTTTTACAAAGTGATCGAAAGTTTTATCAA AGCAGAAGGCAACTTGACAAGAGAAATGATAAAACATTTAGAACGATGTGAACATCGAATCATGGAATCCCTTGCATGGCTCTCAGATTC ACCTTTATTTGATCTTATTAAACAATCAAAGGACCGAGAAGGACCAACTGATCACCTTGAATCTGCTTGTCCTCTTAATCTTCCTCTCCA GAATAATCACACTGCAGCAGATATGTATCTTTCTCCTGTAAGATCTCCAAAGAAAAAAGGTTCAACTACGCGTGTAAATTCTACTGCAAA TGCAGAGACACAAGCAACCTCAGCCTTCCAGACCCAGAAGCCATTGAAATCTACCTCTCTTTCACTGTTTTATAAAAAAGTGTATCGGCT AGCCTATCTCCGGCTAAATACACTTTGTGAACGCCTTCTGTCTGAGCACCCAGAATTAGAACATATCATCTGGACCCTTTTCCAGCACAC CCTGCAGAATGAGTATGAACTCATGAGAGACAGGCATTTGGACCAAATTATGATGTGTTCCATGTATGGCATATGCAAAGTGAAGAATAT AGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGA GGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCC TACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTC ACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGA ATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAA CCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATT TCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGA >In-frame_MYO10_ENST00000515803_chr5_16689933_-_RB1_ENST00000267163_chr13_48934153_+_4093nt ATGCTGGAGACTGTGAGAATCCGCAAAGCTGGGTATGCGGTCCGAAGACCCTTTCAGGACTTTTACAAAAGGTATAAAGTGCTGATGAGG AATCTGGCTCTGCCTGAGGACGTCCGAGGGAAGTGCACGAGCCTGCTGCAGCTCTATGATGCCTCCAACAGCGAGTGGCAGCTGGGGAAG ACCAAGGTCTTTCTTCGAGAATCCTTGGAACAGAAACTGGAGAAGCGGAGGGAAGAGGAAGTGAGCCACGCGGCCATGGTGATTCGGGCC CATGTCTTGGGCTTCTTAGCACGAAAACAATACAGAAAGGTCCTTTATTGTGTGGTGATAATACAGAAGAATTACAGAGCATTCCTTCTG AGGAGGAGATTTTTGCACCTGAAAAAGGCAGCCATAGTTTTCCAGAAGCAACTCAGAGGTCAGATTGCTCGGAGAGTTTACAGACAATTG CTGGCAGAGAAAAGGGAGCAAGAAGAAAAGAAGAAACAGGAAGAGGAAGAAAAGAAGAAACGGGAGGAAGAAGAAAGAGAAAGAGAGAGA GAGCGAAGAGAAGCCGAGCTCCGCGCCCAGCAGGAAGAAGAAACGAGGAAGCAGCAAGAACTCGAAGCCTTGCAGAAGAGCCAGAAGGAA GCTGAACTGACCCGTGAACTGGAGAAACAGAAGGAAAATAAGCAGGTGGAAGAGATCCTCCGTCTGGAGAAAGAAATCGAGGACCTGCAG CGCATGAAGGAGCAGCAGGAGCTGTCGCTGACCGAGGCTTCCCTGCAGAAGCTGCAGGAGCGGCGGGACCAGGAGCTCCGCAGGCTGGAG GAGGAAGCGTGCAGGGCGGCCCAGGAGTTCCTCGAGTCCCTCAATTTCGACGAGATCGACGAGTGTGTCCGGAATATCGAGCGGTCCCTG TCGGTGGGAAGCGAATTTTCCAGCGAGCTGGCTGAGAGCGCATGCGAGGAGAAGCCCAACTTCAACTTCAGCCAGCCCTACCCAGAGGAG GAGGTCGATGAGGGCTTCGAAGCCGACGACGACGCCTTCAAGGACTCCCCCAACCCCAGCGAGCACGGCCACTCAGACCAGCGAACAAGT GGCATCCGGACCAGCGATGACTCTTCAGAGGAGGACCCATACATGAACGACACGGTGGTGCCCACCAGCCCCAGTGCGGACAGCACGGTG CTGCTCGCCCCATCAGTGCAGGACTCCGGGAGCCTACACAACTCCTCCAGCGGCGAGTCCACCTACTGCATGCCCCAGAACGCTGGGGAC TTGCCCTCCCCAGACGGCGACTACGACTACGACCAGGATGACTATGAGGACGGTGCCATCACTTCCGGCAGCAGCGTGACCTTCTCCAAC TCCTACGGCAGCCAGTGGTCCCCCGACTACCGCTGCTCTGTGGGGACCTACAACAGCTCGGGTGCCTACCGGTTCAGCTCTGAGGGGGCG CAGTCCTCGTTTGAAGATAGTGAAGAGGACTTTGATTCCAGGTTTGATACAGATGATGAGCTTTCATACCGGCGTGACTCTGTGTACAGC TGTGTCACTCTGCCGTATTTCCACAGCTTTCTGTACATGAAAGGTGGCCTGATGAACTCTTGGAAACGCCGCTGGTGCGTCCTCAAGGAT GAAACCTTCTTGTGGTTCCGCTCCAAGCAGGAGGCCCTCAAGCAAGGCTGGCTCCACAAAAAAGGGGGGGGCTCCTCCACGCTGTCCAGG AGAAATTGGAAGAAGCGCTGGTTTGTCCTCCGCCAGTCCAAGCTGATGTACTTTGAAAACGACAGCGAGGAGAAGCTCAAGGGCACCGTA GAAGTGCGAACGGCAAAAGAGATCATAGATAACACCACCAAGGAGAATGGGATCGACATCATTATGGCCGATAGGACTTTCCACCTGATT GCAGAGTCCCCAGAAGATGCCAGGGGAAGTATTACAAATGGAAGATGATCTGGTGATTTCATTTCAGTTAATGCTATGTGTCCTTGACTA TTTTATTAAACTCTCACCTCCCATGTTGCTCAAAGAACCATATAAAACAGCTGTTATACCCATTAATGGTTCACCTCGAACACCCAGGCG AGGTCAGAACAGGAGTGCACGGATAGCAAAACAACTAGAAAATGATACAAGAATTATTGAAGTTCTCTGTAAAGAACATGAATGTAATAT AGATGAGGTGAAAAATGTTTATTTCAAAAATTTTATACCTTTTATGAATTCTCTTGGACTTGTAACATCTAATGGACTTCCAGAGGTTGA AAATCTTTCTAAACGATACGAAGAAATTTATCTTAAAAATAAAGATCTAGATGCAAGATTATTTTTGGATCATGATAAAACTCTTCAGAC TGATTCTATAGACAGTTTTGAAACACAGAGAACACCACGAAAAAGTAACCTTGATGAAGAGGTGAATGTAATTCCTCCACACACTCCAGT TAGGACTGTTATGAACACTATCCAACAATTAATGATGATTTTAAATTCAGCAAGTGATCAACCTTCAGAAAATCTGATTTCCTATTTTAA CAACTGCACAGTGAATCCAAAAGAAAGTATACTGAAAAGAGTGAAGGATATAGGATACATCTTTAAAGAGAAATTTGCTAAAGCTGTGGG ACAGGGTTGTGTCGAAATTGGATCACAGCGATACAAACTTGGAGTTCGCTTGTATTACCGAGTAATGGAATCCATGCTTAAATCAGAAGA AGAACGATTATCCATTCAAAATTTTAGCAAACTTCTGAATGACAACATTTTTCATATGTCTTTATTGGCGTGCGCTCTTGAGGTTGTAAT GGCCACATATAGCAGAAGTACATCTCAGAATCTTGATTCTGGAACAGATTTGTCTTTCCCATGGATTCTGAATGTGCTTAATTTAAAAGC CTTTGATTTTTACAAAGTGATCGAAAGTTTTATCAAAGCAGAAGGCAACTTGACAAGAGAAATGATAAAACATTTAGAACGATGTGAACA TCGAATCATGGAATCCCTTGCATGGCTCTCAGATTCACCTTTATTTGATCTTATTAAACAATCAAAGGACCGAGAAGGACCAACTGATCA CCTTGAATCTGCTTGTCCTCTTAATCTTCCTCTCCAGAATAATCACACTGCAGCAGATATGTATCTTTCTCCTGTAAGATCTCCAAAGAA AAAAGGTTCAACTACGCGTGTAAATTCTACTGCAAATGCAGAGACACAAGCAACCTCAGCCTTCCAGACCCAGAAGCCATTGAAATCTAC CTCTCTTTCACTGTTTTATAAAAAAGTGTATCGGCTAGCCTATCTCCGGCTAAATACACTTTGTGAACGCCTTCTGTCTGAGCACCCAGA ATTAGAACATATCATCTGGACCCTTTTCCAGCACACCCTGCAGAATGAGTATGAACTCATGAGAGACAGGCATTTGGACCAAATTATGAT GTGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGT TCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAA AACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTC ACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAAT GACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAG CGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGC AGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MYO10_ENST00000274203_chr5_16689933_-_RB1_ENST00000267163_chr13_48934153_+_6314nt TGCACTTGCTACCCTTCTGCAGGAAGCTTCCCAGCCAGCACAGTTTCTCTCTGCCCTGCCTCTTAATCCCCACCCCTGCTCCCAGGCCTG GGACACTGCTAACCACCCCTCCTTCCTGACACCTCTCTGACCACCCCTCCTCCTCTTGACTGGTTCCTCTGGAGGTAGGCATGGCCTCGG GTTCTGCCCCCAGTTTCTCACTCGCTGGGCTCCAAAAGAAACACTGGCTTCTCTCCTTCAGCTCCAGGCTAGATGCCAGACCAGTTTGAC CAGGCGGTTGTGCTGAACCAGCTGCGGTACTCAGGGATGCTGGAGACTGTGAGAATCCGCAAAGCTGGGTATGCGGTCCGAAGACCCTTT CAGGACTTTTACAAAAGGTATAAAGTGCTGATGAGGAATCTGGCTCTGCCTGAGGACGTCCGAGGGAAGTGCACGAGCCTGCTGCAGCTC TATGATGCCTCCAACAGCGAGTGGCAGCTGGGGAAGACCAAGGTCTTTCTTCGAGAATCCTTGGAACAGAAACTGGAGAAGCGGAGGGAA GAGGAAGTGAGCCACGCGGCCATGGTGATTCGGGCCCATGTCTTGGGCTTCTTAGCACGAAAACAATACAGAAAGGTCCTTTATTGTGTG GTGATAATACAGAAGAATTACAGAGCATTCCTTCTGAGGAGGAGATTTTTGCACCTGAAAAAGGCAGCCATAGTTTTCCAGAAGCAACTC AGAGGTCAGATTGCTCGGAGAGTTTACAGACAATTGCTGGCAGAGAAAAGGGAGCAAGAAGAAAAGAAGAAACAGGAAGAGGAAGAAAAG AAGAAACGGGAGGAAGAAGAAAGAGAAAGAGAGAGAGAGCGAAGAGAAGCCGAGCTCCGCGCCCAGCAGGAAGAAGAAACGAGGAAGCAG CAAGAACTCGAAGCCTTGCAGAAGAGCCAGAAGGAAGCTGAACTGACCCGTGAACTGGAGAAACAGAAGGAAAATAAGCAGGTGGAAGAG ATCCTCCGTCTGGAGAAAGAAATCGAGGACCTGCAGCGCATGAAGGAGCAGCAGGAGCTGTCGCTGACCGAGGCTTCCCTGCAGAAGCTG CAGGAGCGGCGGGACCAGGAGCTCCGCAGGCTGGAGGAGGAAGCGTGCAGGGCGGCCCAGGAGTTCCTCGAGTCCCTCAATTTCGACGAG ATCGACGAGTGTGTCCGGAATATCGAGCGGTCCCTGTCGGTGGGAAGCGAATTTTCCAGCGAGCTGGCTGAGAGCGCATGCGAGGAGAAG CCCAACTTCAACTTCAGCCAGCCCTACCCAGAGGAGGAGGTCGATGAGGGCTTCGAAGCCGACGACGACGCCTTCAAGGACTCCCCCAAC CCCAGCGAGCACGGCCACTCAGACCAGCGAACAAGTGGCATCCGGACCAGCGATGACTCTTCAGAGGAGGACCCATACATGAACGACACG GTGGTGCCCACCAGCCCCAGTGCGGACAGCACGGTGCTGCTCGCCCCATCAGTGCAGGACTCCGGGAGCCTACACAACTCCTCCAGCGGC GAGTCCACCTACTGCATGCCCCAGAACGCTGGGGACTTGCCCTCCCCAGACGGCGACTACGACTACGACCAGGATGACTATGAGGACGGT GCCATCACTTCCGGCAGCAGCGTGACCTTCTCCAACTCCTACGGCAGCCAGTGGTCCCCCGACTACCGCTGCTCTGTGGGGACCTACAAC AGCTCGGGTGCCTACCGGTTCAGCTCTGAGGGGGCGCAGTCCTCGTTTGAAGATAGTGAAGAGGACTTTGATTCCAGGTTTGATACAGAT GATGAGCTTTCATACCGGCGTGACTCTGTGTACAGCTGTGTCACTCTGCCGTATTTCCACAGCTTTCTGTACATGAAAGGTGGCCTGATG AACTCTTGGAAACGCCGCTGGTGCGTCCTCAAGGATGAAACCTTCTTGTGGTTCCGCTCCAAGCAGGAGGCCCTCAAGCAAGGCTGGCTC CACAAAAAAGGGGGGGGCTCCTCCACGCTGTCCAGGAGAAATTGGAAGAAGCGCTGGTTTGTCCTCCGCCAGTCCAAGCTGATGTACTTT GAAAACGACAGCGAGGAGAAGCTCAAGGGCACCGTAGAAGTGCGAACGGCAAAAGAGATCATAGATAACACCACCAAGGAGAATGGGATC GACATCATTATGGCCGATAGGACTTTCCACCTGATTGCAGAGTCCCCAGAAGATGCCAGGGGAAGTATTACAAATGGAAGATGATCTGGT GATTTCATTTCAGTTAATGCTATGTGTCCTTGACTATTTTATTAAACTCTCACCTCCCATGTTGCTCAAAGAACCATATAAAACAGCTGT TATACCCATTAATGGTTCACCTCGAACACCCAGGCGAGGTCAGAACAGGAGTGCACGGATAGCAAAACAACTAGAAAATGATACAAGAAT TATTGAAGTTCTCTGTAAAGAACATGAATGTAATATAGATGAGGTGAAAAATGTTTATTTCAAAAATTTTATACCTTTTATGAATTCTCT TGGACTTGTAACATCTAATGGACTTCCAGAGGTTGAAAATCTTTCTAAACGATACGAAGAAATTTATCTTAAAAATAAAGATCTAGATGC AAGATTATTTTTGGATCATGATAAAACTCTTCAGACTGATTCTATAGACAGTTTTGAAACACAGAGAACACCACGAAAAAGTAACCTTGA TGAAGAGGTGAATGTAATTCCTCCACACACTCCAGTTAGGACTGTTATGAACACTATCCAACAATTAATGATGATTTTAAATTCAGCAAG TGATCAACCTTCAGAAAATCTGATTTCCTATTTTAACAACTGCACAGTGAATCCAAAAGAAAGTATACTGAAAAGAGTGAAGGATATAGG ATACATCTTTAAAGAGAAATTTGCTAAAGCTGTGGGACAGGGTTGTGTCGAAATTGGATCACAGCGATACAAACTTGGAGTTCGCTTGTA TTACCGAGTAATGGAATCCATGCTTAAATCAGAAGAAGAACGATTATCCATTCAAAATTTTAGCAAACTTCTGAATGACAACATTTTTCA TATGTCTTTATTGGCGTGCGCTCTTGAGGTTGTAATGGCCACATATAGCAGAAGTACATCTCAGAATCTTGATTCTGGAACAGATTTGTC TTTCCCATGGATTCTGAATGTGCTTAATTTAAAAGCCTTTGATTTTTACAAAGTGATCGAAAGTTTTATCAAAGCAGAAGGCAACTTGAC AAGAGAAATGATAAAACATTTAGAACGATGTGAACATCGAATCATGGAATCCCTTGCATGGCTCTCAGATTCACCTTTATTTGATCTTAT TAAACAATCAAAGGACCGAGAAGGACCAACTGATCACCTTGAATCTGCTTGTCCTCTTAATCTTCCTCTCCAGAATAATCACACTGCAGC AGATATGTATCTTTCTCCTGTAAGATCTCCAAAGAAAAAAGGTTCAACTACGCGTGTAAATTCTACTGCAAATGCAGAGACACAAGCAAC CTCAGCCTTCCAGACCCAGAAGCCATTGAAATCTACCTCTCTTTCACTGTTTTATAAAAAAGTGTATCGGCTAGCCTATCTCCGGCTAAA TACACTTTGTGAACGCCTTCTGTCTGAGCACCCAGAATTAGAACATATCATCTGGACCCTTTTCCAGCACACCCTGCAGAATGAGTATGA ACTCATGAGAGACAGGCATTTGGACCAAATTATGATGTGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAAT CATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTAT AGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACC TCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATA TAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGA GAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAA AAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGA AATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGA CCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTT AATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTAT TTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTT ATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGT TTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCA ATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTA CACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCA AAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAAC TTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGA AAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAG AATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCAT CTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAAT TGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAA TCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCG CTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATAT TTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAA ATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCAT CATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTA GAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTT GTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAG AGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTAGGAGAAGATAGATAGAAGATAACTCTC >In-frame_MYO10_ENST00000515803_chr5_16689933_-_RB1_ENST00000267163_chr13_48934153_+_6341nt TTCTTTCTAATGCCAGGCAATCAAGGCTGCACTTGCTACCCTTCTGCAGGAAGCTTCCCAGCCAGCACAGTTTCTCTCTGCCCTGCCTCT TAATCCCCACCCCTGCTCCCAGGCCTGGGACACTGCTAACCACCCCTCCTTCCTGACACCTCTCTGACCACCCCTCCTCCTCTTGACTGG TTCCTCTGGAGGTAGGCATGGCCTCGGGTTCTGCCCCCAGTTTCTCACTCGCTGGGCTCCAAAAGAAACACTGGCTTCTCTCCTTCAGCT CCAGGCTAGATGCCAGACCAGTTTGACCAGGCGGTTGTGCTGAACCAGCTGCGGTACTCAGGGATGCTGGAGACTGTGAGAATCCGCAAA GCTGGGTATGCGGTCCGAAGACCCTTTCAGGACTTTTACAAAAGGTATAAAGTGCTGATGAGGAATCTGGCTCTGCCTGAGGACGTCCGA GGGAAGTGCACGAGCCTGCTGCAGCTCTATGATGCCTCCAACAGCGAGTGGCAGCTGGGGAAGACCAAGGTCTTTCTTCGAGAATCCTTG GAACAGAAACTGGAGAAGCGGAGGGAAGAGGAAGTGAGCCACGCGGCCATGGTGATTCGGGCCCATGTCTTGGGCTTCTTAGCACGAAAA CAATACAGAAAGGTCCTTTATTGTGTGGTGATAATACAGAAGAATTACAGAGCATTCCTTCTGAGGAGGAGATTTTTGCACCTGAAAAAG GCAGCCATAGTTTTCCAGAAGCAACTCAGAGGTCAGATTGCTCGGAGAGTTTACAGACAATTGCTGGCAGAGAAAAGGGAGCAAGAAGAA AAGAAGAAACAGGAAGAGGAAGAAAAGAAGAAACGGGAGGAAGAAGAAAGAGAAAGAGAGAGAGAGCGAAGAGAAGCCGAGCTCCGCGCC CAGCAGGAAGAAGAAACGAGGAAGCAGCAAGAACTCGAAGCCTTGCAGAAGAGCCAGAAGGAAGCTGAACTGACCCGTGAACTGGAGAAA CAGAAGGAAAATAAGCAGGTGGAAGAGATCCTCCGTCTGGAGAAAGAAATCGAGGACCTGCAGCGCATGAAGGAGCAGCAGGAGCTGTCG CTGACCGAGGCTTCCCTGCAGAAGCTGCAGGAGCGGCGGGACCAGGAGCTCCGCAGGCTGGAGGAGGAAGCGTGCAGGGCGGCCCAGGAG TTCCTCGAGTCCCTCAATTTCGACGAGATCGACGAGTGTGTCCGGAATATCGAGCGGTCCCTGTCGGTGGGAAGCGAATTTTCCAGCGAG CTGGCTGAGAGCGCATGCGAGGAGAAGCCCAACTTCAACTTCAGCCAGCCCTACCCAGAGGAGGAGGTCGATGAGGGCTTCGAAGCCGAC GACGACGCCTTCAAGGACTCCCCCAACCCCAGCGAGCACGGCCACTCAGACCAGCGAACAAGTGGCATCCGGACCAGCGATGACTCTTCA GAGGAGGACCCATACATGAACGACACGGTGGTGCCCACCAGCCCCAGTGCGGACAGCACGGTGCTGCTCGCCCCATCAGTGCAGGACTCC GGGAGCCTACACAACTCCTCCAGCGGCGAGTCCACCTACTGCATGCCCCAGAACGCTGGGGACTTGCCCTCCCCAGACGGCGACTACGAC TACGACCAGGATGACTATGAGGACGGTGCCATCACTTCCGGCAGCAGCGTGACCTTCTCCAACTCCTACGGCAGCCAGTGGTCCCCCGAC TACCGCTGCTCTGTGGGGACCTACAACAGCTCGGGTGCCTACCGGTTCAGCTCTGAGGGGGCGCAGTCCTCGTTTGAAGATAGTGAAGAG GACTTTGATTCCAGGTTTGATACAGATGATGAGCTTTCATACCGGCGTGACTCTGTGTACAGCTGTGTCACTCTGCCGTATTTCCACAGC TTTCTGTACATGAAAGGTGGCCTGATGAACTCTTGGAAACGCCGCTGGTGCGTCCTCAAGGATGAAACCTTCTTGTGGTTCCGCTCCAAG CAGGAGGCCCTCAAGCAAGGCTGGCTCCACAAAAAAGGGGGGGGCTCCTCCACGCTGTCCAGGAGAAATTGGAAGAAGCGCTGGTTTGTC CTCCGCCAGTCCAAGCTGATGTACTTTGAAAACGACAGCGAGGAGAAGCTCAAGGGCACCGTAGAAGTGCGAACGGCAAAAGAGATCATA GATAACACCACCAAGGAGAATGGGATCGACATCATTATGGCCGATAGGACTTTCCACCTGATTGCAGAGTCCCCAGAAGATGCCAGGGGA AGTATTACAAATGGAAGATGATCTGGTGATTTCATTTCAGTTAATGCTATGTGTCCTTGACTATTTTATTAAACTCTCACCTCCCATGTT GCTCAAAGAACCATATAAAACAGCTGTTATACCCATTAATGGTTCACCTCGAACACCCAGGCGAGGTCAGAACAGGAGTGCACGGATAGC AAAACAACTAGAAAATGATACAAGAATTATTGAAGTTCTCTGTAAAGAACATGAATGTAATATAGATGAGGTGAAAAATGTTTATTTCAA AAATTTTATACCTTTTATGAATTCTCTTGGACTTGTAACATCTAATGGACTTCCAGAGGTTGAAAATCTTTCTAAACGATACGAAGAAAT TTATCTTAAAAATAAAGATCTAGATGCAAGATTATTTTTGGATCATGATAAAACTCTTCAGACTGATTCTATAGACAGTTTTGAAACACA GAGAACACCACGAAAAAGTAACCTTGATGAAGAGGTGAATGTAATTCCTCCACACACTCCAGTTAGGACTGTTATGAACACTATCCAACA ATTAATGATGATTTTAAATTCAGCAAGTGATCAACCTTCAGAAAATCTGATTTCCTATTTTAACAACTGCACAGTGAATCCAAAAGAAAG TATACTGAAAAGAGTGAAGGATATAGGATACATCTTTAAAGAGAAATTTGCTAAAGCTGTGGGACAGGGTTGTGTCGAAATTGGATCACA GCGATACAAACTTGGAGTTCGCTTGTATTACCGAGTAATGGAATCCATGCTTAAATCAGAAGAAGAACGATTATCCATTCAAAATTTTAG CAAACTTCTGAATGACAACATTTTTCATATGTCTTTATTGGCGTGCGCTCTTGAGGTTGTAATGGCCACATATAGCAGAAGTACATCTCA GAATCTTGATTCTGGAACAGATTTGTCTTTCCCATGGATTCTGAATGTGCTTAATTTAAAAGCCTTTGATTTTTACAAAGTGATCGAAAG TTTTATCAAAGCAGAAGGCAACTTGACAAGAGAAATGATAAAACATTTAGAACGATGTGAACATCGAATCATGGAATCCCTTGCATGGCT CTCAGATTCACCTTTATTTGATCTTATTAAACAATCAAAGGACCGAGAAGGACCAACTGATCACCTTGAATCTGCTTGTCCTCTTAATCT TCCTCTCCAGAATAATCACACTGCAGCAGATATGTATCTTTCTCCTGTAAGATCTCCAAAGAAAAAAGGTTCAACTACGCGTGTAAATTC TACTGCAAATGCAGAGACACAAGCAACCTCAGCCTTCCAGACCCAGAAGCCATTGAAATCTACCTCTCTTTCACTGTTTTATAAAAAAGT GTATCGGCTAGCCTATCTCCGGCTAAATACACTTTGTGAACGCCTTCTGTCTGAGCACCCAGAATTAGAACATATCATCTGGACCCTTTT CCAGCACACCCTGCAGAATGAGTATGAACTCATGAGAGACAGGCATTTGGACCAAATTATGATGTGTTCCATGTATGGCATATGCAAAGT GAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGAT CAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCAC CAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACAT CTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATC AATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGA AGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGA GTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAA CAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTT TCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAA GCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCC TCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTG CCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAA ATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTA GAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTG CTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGA ACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAA TTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGC ACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTT TTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGT CTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACA TTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATT AAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGA GATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAA AGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATG ACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCT GGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTT CAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGT CTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTA |
Top |
FusionGenePPI for MYO10_RB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MYO10 | CALM3, FBXW11, TERF2, PRKCI, KIAA0368, CAND1, PAN2, XPO1, MYO19, PARD6B, JPH4, BTRC, TRIM25, TES | RB1 | CUX1, MCM7, HBP1, TRAP1, AATF, THOC1, LIN9, BRCA1, ABL1, BCR, NCOA6, BAG1, RBBP8, HDAC1, AR, MORF4L2, SERPINB2, TP73, GNB2L1, CBX1, PELP1, PIK3R3, PPARG, HDAC3, RBBP4, E2F1, MORF4L1, MRFAP1, RBBP7, CDK2, DNMT1, HDAC2, ARID4A, NFIX, SP1, SMARCA4, MYOD1, DNMT3A, EID1, BRF1, PRDM2, SUV39H1, CBX5, CBX4, RING1, VDR, KDM5A, CCND3, PML, CCND1, TAF1, PA2G4, TMPO, MYC, TGM2, POLA1, FRK, ATF2, SNW1, ARID3B, SNAPC1, SNAPC3, CCNT2, CDK9, RAF1, E2F4, E4F1, ENC1, RFC1, LMNA, CREG1, CEBPB, HMGB1, PHB, MDM2, JUN, PAX6, MNAT1, RBBP5, E2F2, TRIP11, UBTF, AHR, ARNT, CCNA1, TFDP1, TFDP2, RBBP9, TBP, USP4, L3MBTL1, L3MBTL2, AURKB, CDK4, ZBTB7A, SKP2, HMGA2, KDM5B, KDM4A, STAT3, KDM1A, LIN54, SKI, SKIL, KAT2B, FOXM1, YY1, DNAJA2, SMYD2, UHRF2, TAL1, TCF3, LMO2, LDB1, IRF3, NPM1, CEBPA, KAT5, TRIM27, CCNE1, CDK5, CCND2, PSMA7, CCNA2, CDK1, PSMD10, CDC27, ANAPC2, CDC16, FZR1, MAPK14, TP53, PPP1CA, CDK6, RNF40, UHRF1, UBR4, RBAK, SPI1, E2F3, CHEK2, CHEK1, CEBPD, MDM4, PAX2, PNO1, GTF2H1, PURA, CCNB1, RINT1, FOS, CDK14, PPIA, TOP2A, NOTCH1, RUNX2, ID2, CDK3, DGKZ, INS, HIST4H4, PRMT2, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, MAPK8, UBE2I, CEBPE, MRPS18B, CCNC, PRKCB, TFAP2A, PAX5, HIF1A, CDKN1A, CDKN1C, HDAC11, PLA2G12A, MAGEA11, NEFM, DYRK1A, DYRK1B, USP7, KDM2A, EP300, SIRT1, PAX8, KLK11, RFPL2, FAS, TFDP3, CTBP1, C3orf62, CDK13, NTRK1, RBBP6, GTF3C2, GRB2, RABGAP1L, CHN2, ANKS1A, CLNK, MED23, BAG6, UBL4A, HERC4, RPRD1B, RBM26, FOXA3, FOXK1, FOXK2, FOXO1, FOXO3, PPP1R26, NFATC2, BRD4, FAM208A, RFC5, PPAN, KIAA0430, HELZ, PCGF3, HSP90AA1, WEE1, TUBA1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MYO10_RB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | RB1 | P06400 | DB00071 | Insulin Pork | Retinoblastoma-associated protein | biotech | approved |
| Tgene | RB1 | P06400 | DB00030 | Insulin Human | Retinoblastoma-associated protein | biotech | approved|investigational |
Top |
RelatedDiseases for MYO10_RB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MYO10 | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | RB1 | C0035335 | Retinoblastoma | 9 | CTD_human;HPO;UNIPROT |
| Tgene | RB1 | C1458155 | Mammary Neoplasms | 3 | CTD_human |
| Tgene | RB1 | C0149925 | Small cell carcinoma of lung | 2 | CTD_human;ORPHANET |
| Tgene | RB1 | C2239176 | Liver carcinoma | 2 | CTD_human |
| Tgene | RB1 | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human |
| Tgene | RB1 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
| Tgene | RB1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | RB1 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Tgene | RB1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| Tgene | RB1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | RB1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | RB1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | RB1 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| Tgene | RB1 | C0029463 | Osteosarcoma | 1 | CTD_human;HPO |
| Tgene | RB1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | RB1 | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | RB1 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
| Tgene | RB1 | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Tgene | RB1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | RB1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|