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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23077

FusionGeneSummary for MYNN_SMAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYNN_SMAP1
Fusion gene ID: 23077
HgeneTgene
Gene symbol

MYNN

SMAP1

Gene ID

55892

60682

Gene namemyoneurinsmall ArfGAP 1
SynonymsOSZF|SBBIZ1|ZBTB31|ZNF902SMAP-1
Cytomap

3q26.2

6q13

Type of geneprotein-codingprotein-coding
Descriptionmyoneurinzinc finger and BTB domain-containing protein 31zinc finger protein with BTB/POZ domainstromal membrane-associated protein 1stromal membrane-associated GTPase-activating protein 1
Modification date2018052320180523
UniProtAcc

Q9NPC7

Q8IYB5

Ensembl transtripts involved in fusion geneENST00000349841, ENST00000392733, 
ENST00000356716, ENST00000544106, 
ENST00000316999, ENST00000370452, 
ENST00000370455, ENST00000422334, 
Fusion gene scores* DoF score2 X 3 X 2=125 X 4 X 4=80
# samples 25
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYNN [Title/Abstract] AND SMAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CK431053MYNNchr3

169495312

+SMAP1chr6

71445757

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000349841ENST00000316999MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000349841ENST00000370452MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000349841ENST00000370455MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000349841ENST00000422334MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000392733ENST00000316999MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000392733ENST00000370452MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000392733ENST00000370455MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000392733ENST00000422334MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000356716ENST00000316999MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000356716ENST00000370452MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000356716ENST00000370455MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000356716ENST00000422334MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000544106ENST00000316999MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000544106ENST00000370452MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000544106ENST00000370455MYNNchr3

169495312

+SMAP1chr6

71445757

+
intron-intronENST00000544106ENST00000422334MYNNchr3

169495312

+SMAP1chr6

71445757

+

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FusionProtFeatures for MYNN_SMAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYNN

Q9NPC7

SMAP1

Q8IYB5

GTPase activating protein that acts on ARF6. Plays arole in clathrin-dependent endocytosis. May play a role inerythropoiesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYNN_SMAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYNN_SMAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYNN_SMAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYNN_SMAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource