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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23055

FusionGeneSummary for MYL6_ZNFX1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYL6_ZNFX1
Fusion gene ID: 23055
HgeneTgene
Gene symbol

MYL6

ZNFX1

Gene ID

4637

57169

Gene namemyosin light chain 6zinc finger NFX1-type containing 1
SynonymsESMLC|LC17|LC17-GI|LC17-NM|LC17A|LC17B|MLC-3|MLC1SM|MLC3NM|MLC3SM-
Cytomap

12q13.2

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionmyosin light polypeptide 617 kDa myosin light chainmyosin light chain A3myosin light chain alkali 3myosin, light chain 6, alkali, smooth muscle and non-musclemyosin, light polypeptide 6, alkali, smooth muscle and non-muscleNFX1-type zinc finger-containing protein 1
Modification date2018052220180523
UniProtAcc

P60660

Q9P2E3

Ensembl transtripts involved in fusion geneENST00000550697, ENST00000548580, 
ENST00000293422, ENST00000348108, 
ENST00000549017, ENST00000549566, 
ENST00000536128, ENST00000547649, 
ENST00000547408, ENST00000551589, 
ENST00000548400, ENST00000548293, 
ENST00000551954, 		ENST00000371754, 
ENST00000469991, ENST00000371752, 
ENST00000396105, 
Fusion gene scores* DoF score11 X 6 X 8=52827 X 5 X 14=1890
# samples 1131
** MAII scorelog2(11/528*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/1890*10)=-2.6080461138342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYL6 [Title/Abstract] AND ZNFX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A3SM-01AMYL6chr12

56555359

+ZNFX1chr20

47863418

-
TCGARVHNSCTCGA-BA-5559-01AMYL6chr12

56555358

+ZNFX1chr20

47863418

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000550697ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000550697ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000550697ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000550697ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000548580ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000548580ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000548580ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000548580ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000293422ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000293422ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000293422ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000293422ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
3UTR-intronENST00000348108ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
3UTR-intronENST00000348108ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
3UTR-3UTRENST00000348108ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
3UTR-3UTRENST00000348108ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000549017ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000549017ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000549017ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000549017ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000549566ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000549566ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000549566ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000549566ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000536128ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000536128ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000536128ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000536128ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000547649ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000547649ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000547649ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000547649ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000547408ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000547408ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000547408ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000547408ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000551589ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000551589ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000551589ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000551589ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000548400ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000548400ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000548400ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000548400ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000548293ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000548293ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000548293ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000548293ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000551954ENST00000371754MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-intronENST00000551954ENST00000469991MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000551954ENST00000371752MYL6chr12

56555359

+ZNFX1chr20

47863418

-
intron-3UTRENST00000551954ENST00000396105MYL6chr12

56555359

+ZNFX1chr20

47863418

-
5CDS-intronENST00000550697ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000550697ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000550697ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000550697ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000548580ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000548580ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000548580ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000548580ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000293422ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000293422ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000293422ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000293422ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
3UTR-intronENST00000348108ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
3UTR-intronENST00000348108ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
3UTR-3UTRENST00000348108ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
3UTR-3UTRENST00000348108ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000549017ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000549017ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000549017ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000549017ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000549566ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000549566ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000549566ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000549566ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000536128ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000536128ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000536128ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000536128ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000547649ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000547649ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000547649ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000547649ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000547408ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000547408ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000547408ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000547408ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000551589ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000551589ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000551589ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000551589ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000548400ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-intronENST00000548400ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000548400ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000548400ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000548293ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000548293ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000548293ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000548293ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000551954ENST00000371754MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-intronENST00000551954ENST00000469991MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000551954ENST00000371752MYL6chr12

56555358

+ZNFX1chr20

47863418

-
intron-3UTRENST00000551954ENST00000396105MYL6chr12

56555358

+ZNFX1chr20

47863418

-

Top

FusionProtFeatures for MYL6_ZNFX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYL6

P60660

ZNFX1

Q9P2E3

Regulatory light chain of myosin. Does not bind calcium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYL6_ZNFX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYL6_ZNFX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYL6NUDT21, EWSR1, DNAJB9, MOB4, USP18, USP46, USP45, SRRM2, ESR1, ARRB1, ARRB2, CDK2, CUL1, LRRK2, MYH9, HSP90AB1, MYL6B, DES, ATP5B, TSGA10, FN1, VCAM1, MLH1, ITGA4, PAN2, GLP1R, MYH14, GRIPAP1, MYL12A, ADAMTS12, SUZ12, LGALS3, AHCYL1, AHNAK, CYC1, HSD17B10, PHGDH, RCN1, REXO2, RAB2A, STMN1, TPM2, MYH11, CBX4, IQGAP1, PDLIM7, ANLN, MYO19, BOD1L1, MYO18A, MCM2, FAM210A, PPP1R9A, LIMA1, IQGAP3, RANBP1, MYH10, RAC1, CALM1, TRIM25, TES, DCAF4L2, HDAC6ZNFX1ENO1, SHMT2, MOV10, NXF1, XPO1, FYN, CSDE1, DROSHA, SS18L2, AMZ2, MIEF1, IMP3, DDX27, CDK4, HSF2, PCDH1, PDK1, SCAF11, UGGT1, CXXC4, TUBA1C, DRC1, LACTB, STRAP, OS9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYL6_ZNFX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYL6_ZNFX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource