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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 23010

FusionGeneSummary for MYH9_HSP90AA1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYH9_HSP90AA1
Fusion gene ID: 23010
HgeneTgene
Gene symbol

MYH9

HSP90AA1

Gene ID

4627

3320

Gene namemyosin heavy chain 9heat shock protein 90 alpha family class A member 1
SynonymsBDPLT6|DFNA17|EPSTS|FTNS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCAEL52|HEL-S-65p|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp103|Hsp89|Hsp90|LAP-2|LAP2
Cytomap

22q12.3

14q32.31

Type of geneprotein-codingprotein-coding
Descriptionmyosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-Aheat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shock
Modification date2018052220180527
UniProtAcc

P35579

P07900

Ensembl transtripts involved in fusion geneENST00000216181, ENST00000475726, 
ENST00000401701, 
ENST00000216281, 
ENST00000334701, ENST00000441629, 
ENST00000558600, 
Fusion gene scores* DoF score36 X 33 X 15=1782018 X 19 X 6=2052
# samples 5023
** MAII scorelog2(50/17820*10)=-5.1554254317472
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(23/2052*10)=-3.15732496466268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYH9 [Title/Abstract] AND HSP90AA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYH9

GO:0001525

angiogenesis

16403913

HgeneMYH9

GO:0006509

membrane protein ectodomain proteolysis

16186248

HgeneMYH9

GO:0030048

actin filament-based movement

12237319|15845534

HgeneMYH9

GO:0031032

actomyosin structure organization

24072716

TgeneHSP90AA1

GO:0001934

positive regulation of protein phosphorylation

19363271

TgeneHSP90AA1

GO:0007004

telomere maintenance via telomerase

10197982

TgeneHSP90AA1

GO:0031396

regulation of protein ubiquitination

16809764

TgeneHSP90AA1

GO:0032273

positive regulation of protein polymerization

19363271

TgeneHSP90AA1

GO:0045040

protein import into mitochondrial outer membrane

15644312

TgeneHSP90AA1

GO:0051131

chaperone-mediated protein complex assembly

15644312

TgeneHSP90AA1

GO:0051973

positive regulation of telomerase activity

10197982

TgeneHSP90AA1

GO:1902949

positive regulation of tau-protein kinase activity

19363271

TgeneHSP90AA1

GO:1905323

telomerase holoenzyme complex assembly

10197982


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-D1-A3DG-01AMYH9chr22

36783852

-HSP90AA1chr14

102550901

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000216181ENST00000216281MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
5UTR-3CDSENST00000216181ENST00000334701MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
5UTR-3CDSENST00000216181ENST00000441629MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
5UTR-intronENST00000216181ENST00000558600MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
intron-3CDSENST00000475726ENST00000216281MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
intron-3CDSENST00000475726ENST00000334701MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
intron-3CDSENST00000475726ENST00000441629MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
intron-intronENST00000475726ENST00000558600MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
intron-3CDSENST00000401701ENST00000216281MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
intron-3CDSENST00000401701ENST00000334701MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
intron-3CDSENST00000401701ENST00000441629MYH9chr22

36783852

-HSP90AA1chr14

102550901

-
intron-intronENST00000401701ENST00000558600MYH9chr22

36783852

-HSP90AA1chr14

102550901

-

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FusionProtFeatures for MYH9_HSP90AA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYH9

P35579

HSP90AA1

P07900

Cellular myosin that appears to play a role incytokinesis, cell shape, and specialized functions such assecretion and capping. During cell spreading, plays an importantrole in cytoskeleton reorganization, focal contacts formation (inthe margins but not the central part of spreading cells), andlamellipodial retraction; this function is mechanicallyantagonized by MYH10. {ECO:0000269|PubMed:20052411}. Molecular chaperone that promotes the maturation,structural maintenance and proper regulation of specific targetproteins involved for instance in cell cycle control and signaltransduction. Undergoes a functional cycle that is linked to itsATPase activity which is essential for its chaperone activity.This cycle probably induces conformational changes in the clientproteins, thereby causing their activation. Interacts dynamicallywith various co-chaperones that modulate its substraterecognition, ATPase cycle and chaperone function (PubMed:11274138,PubMed:15577939, PubMed:15937123, PubMed:27353360,PubMed:29127155). Engages with a range of client protein classesvia its interaction with various co-chaperone proteins orcomplexes, that act as adapters, simultaneously able to interactwith the specific client and the central chaperone itself(PubMed:29127155). Recruitment of ATP and co-chaperone followed byclient protein forms a functional chaperone. After the completionof the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformationand finally, ADP is released from HSP90 which acquires an openconformation for the next cycle (PubMed:27295069,PubMed:26991466). Apart from its chaperone activity, it also playsa role in the regulation of the transcription machinery. HSP90 andits co-chaperones modulate transcription at least at threedifferent levels (PubMed:25973397). In the first place, they alterthe steady-state levels of certain transcription factors inresponse to various physiological cues(PubMed:25973397). Second,they modulate the activity of certain epigenetic modifiers, suchas histone deacetylases or DNA methyl transferases, and therebyrespond to the change in the environment (PubMed:25973397). Third,they participate in the eviction of histones from the promoterregion of certain genes and thereby turn on gene expression(PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) andmediates LPS-induced inflammatory response, including TNFsecretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).{ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205,ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123,ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27353360,ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397,ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYH9_HSP90AA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYH9_HSP90AA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYH9EPB41, MARK4, ASCC2, MYL9, PRKCE, USP1, USP45, GRB2, RAC1, YWHAZ, EMD, TERF1, TERF2, CBL, PPP2R4, AGO3, YWHAQ, MME, HDAC5, NCOA3, CREBBP, UBE3A, ARRB1, ARRB2, SIRT7, TRAF4, SP1, ISG15, FBXO25, CDK2, CUL1, TRIM72, GRK5, UBASH3B, PIK3R2, SHC1, MYL6, SPTAN1, HSP90AB1, ACTA2, MYH10, HNRNPU, FLNA, ACTR1A, RAB11A, EIF4B, SEL1L, ATP5A1, SEPT7, RALA, HSPA5, TUBA4A, EIF3A, EIF3C, TPM4, MRPS18B, PSME3, HSPA1A, ESR1, TSGA10, EIF4A3, MAGOH, TRAF3IP1, MEN1, HSP90AA1, VCAM1, FN1, IQCB1, ITGA4, PAN2, ACE, ACTB, CSNK2A1, PIK3C3, PPP2CA, CASP4, TARDBP, AKAP10, CDC73, MYH14, OTUD6B, MYL12A, RPA1, RPA2, RPA3, LGR4, IVNS1ABP, TP53, HUWE1, ALK, UBE2I, EED, AMFR, OS9, SYVN1, ATG9A, USP7, HNRNPA1, ATP5L, MYO1E, SRSF5, SSB, NTRK1, ACTA1, ACTG1, ACTN4, ACTN1, AP2A1, AP2B1, ANXA2, APOB, DST, CALD1, CALM1, CALML3, CAPZA1, CAPZA2, CAPZB, CD44, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CPM, DAB2, DAPK3, DBN1, DSG2, CTTN, STOM, EPS15, FLII, FLNB, FYN, GNAI1, GNAI2, GNAS, GNB2, GSN, HIP1, ITPR2, ITPR3, JUP, LGALS1, ABLIM1, LMO7, LSS, LYN, MYO1B, MSN, PDLIM7, ANLN, MYO19, MYO18A, MYLK, MYO1C, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, NAP1L1, PAWR, PIK3C2A, PLEC, PLS1, PPIA, PPP1CA, PPP1CB, PPP1CC, PSMB10, TWF1, PEX5, RPL22, SIPA1, SORD, SPTBN1, SPTBN2, SSFA2, ST5, SVIL, TCEA2, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, CORO2A, YES1, LUZP1, PICALM, PIP5K1A, SORBS2, IQGAP1, HIP1R, GPRC5A, LRRFIP2, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, ARPC2, BCAP31, FLOT1, BASP1, IMMT, RBPMS, DSTN, TRIOBP, CEP250, AKAP2, TWF2, SYNPO, CEP162, LIMCH1, PALLD, SIPA1L3, MPRIP, COBL, KIF13B, SPECC1L, ATP13A2, MACF1, CORO1C, STX12, GCA, PLEKHG3, RAI14, ZBTB20, AHDC1, PACSIN3, TMOD3, PNMA3, FCF1, CEP83, LIMA1, GTSE1, KDM3B, UACA, CDCA8, BMP2K, UNC45A, MYO5C, GNG12, MUC13, CORO1B, MICAL3, ARHGAP21, SHROOM3, AFAP1, INF2, NARFL, METTL17, AHNAK, EFHD2, CYBRD1, WDR76, DSN1, RNF170, TRIM56, ARPC5L, ANTXR1, LZTS2, PPP1R9B, CEP89, STON2, DOCK7, DIXDC1, SSH2, NEXN, ELMSAN1, SPECC1, CCDC102A, FCHO2, MISP, JMY, CD109, ACTRT1, MYL6B, CCDC50, OARD1, GAS2L3, TTLL6, TPRN, ACTBL2, MCM2, MCM5, SNW1, CDC5L, BOP1, PES1, EGFR, CDH1, C9orf156, MYL3, H2AFY, CYLD, TRIM25, BRCA1, HDAC6HSP90AA1AR, FANCA, FANCC, SMYD3, CDC37, STARD13, BAG4, CHTF18, NOS3, GUCY1B3, HCFC1, MYC, RALBP1, HSF1, TUBA1A, ESR1, FES, CSNK2A1, CSNK2A2, TERT, AKT1, HSP90AA1, RPS3A, NR3C1, TP53, DAP3, SIM1, MYOD1, STIP1, PIM1, HSPA8, EPRS, HSPA1A, SGTA, RAF1, APAF1, CUL4A, STAT3, FNIP1, ERN1, EIF2AK3, IRS4, ARNTL, HIF1A, NPAS2, SRC, AHR, PPARA, FKBP5, GNA12, AHSA1, AHSA2, PTGES3, ERBB2, TGFBR1, TGFBR2, TJP1, FLT3, GUCY1A2, DAPK1, STUB1, RIPK1, MST1R, VCP, HDAC6, RPS3, HSPA4, RPS6, UBE2N, SIN3A, PAK1, JUN, PRKCZ, COPS3, PPP5C, CDK11B, TTI2, MGMT, SP1, STK11, FKBP4, AIP, ABL1, TSSK6, HIST3H3, VEGFA, SMYD2, EGFR, PRMT5, CFTR, ESR2, JAK2, HSP90AB1, HES1, CUL5, PI4K2B, PI4K2A, H2AFX, APP, FGFR3, USP50, RARRES3, CDK5R1, SENP3, PRKAA1, AGO4, CD4, BCR, MAP3K3, HDAC5, MYOCD, MDM2, DYRK2, PRKCI, LRRK2, FBXW8, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, MAP3K7, PSMA3, GBA, EIF2AK1, SVIL, CALM1, NTRK1, FKBPL, CDKN1A, BECN1, BCL2, CHEK1, ATR, REV1, SUGT1, SKP1, PPIL2, LCK, FYN, FKBP8, NDRG1, RAD21, CDC73, CDK9, CDK4, SIRT1, ARRB1, SLC2A4, CHUK, ALG2, MKKS, RCAN1, ISG15, MAP3K14, RNF114, PINK1, POLH, TNK2, NLRP3, NLRP2, NOD1, NLRP4, MIF, UCHL1, STRADA, KCNH2, EPAS1, HIF3A, PIWIL2, PPARD, STK36, GSK3B, CSNK1A1, HOPX, CUL3, CUL4B, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, GRK6, PPP2R1A, MID1, EEF1A1, MET, HDAC8, BRMS1, IKBKB, DSN1, NSL1, PMF1, MIS12, BCL6, IRAK1, BLM, TERF2, NUDC, PAFAH1B1, NUDCD2, DNAJC7, PPID, TARDBP, SNRPE, TUBG1, ACVRL1, STK33, GRK5, TYMP, NOX5, UBASH3B, GRB2, SHC1, IP6K2, MTRNR2L1, FBXO6, SNCA, IRF3, TBK1, PACRG, PARK2, HNRNPA1, RPS15A, NCL, SLC25A5, RPL7, RPL17, HSP90AB3P, TUFM, SSR3, RPL32, RPL5, RPS16, TXNDC5, RPS20, MARCKS, HSP90AA5P, RPL3, HSP90AB2P, LMAN1, SUPT5H, RPL23A, RPL29, WASL, NLRP12, CFLAR, CCT2, TRAF3IP1, MYLK2, CCDC117, TTC9C, TTC4, PLCE1, CDK11A, EFTUD2, CNOT6, PRPF8, FLII, CALD1, USP19, NUDCD3, UNC45A, FAM83H, CACYBP, TAB1, TAB2, CEP97, IKBKG, DYNC1H1, SCRIB, PRR14L, CHORDC1, EDRF1, TOMM34, BAG2, ST13, POLR2E, RPAP3, SNRNP200, PIH1D1, URI1, MLF2, CDC37L1, YTHDC2, HSPA7, HSPA6, HSPA5, HSPA2, HSPA1L, HSPA9, KCNQ4, TCP1, HSPH1, PRKDC, GNAI2, XPO1, PKM, GAPDH, PGK1, LDHA, ALDOA, MDH1, MTHFD1, PSAT1, FASN, NANS, ACTG1, TPM3, FLNA, MYH9, SPTAN1, NUMA1, ACTN1, UBA1, PSMD1, PSMB5, AARS, EEF2, EIF3H, RPLP0, RPS4X, C12orf10, IARS2, RPSA, FN1, VCAM1, AMHR2, ICK, PSKH1, EIF2AK2, ARAF, FER, PSKH2, PKN2, MAST2, PRKACB, CDK15, LIMK2, MAP3K8, MERTK, DYRK4, TIE1, NPRL2, MAPK7, TESK2, MAP3K6, TNK1, EPHB6, CDK7, CSF1R, MAP3K12, EPHB1, ACVR1C, DDR2, FASTK, MYLK4, KSR2, BMPR1A, FRK, PRKY, MOS, MAP3K15, MYO3B, MAP2K5, SGK2, GSK3A, INSRR, ALPK1, GRK4, SGK1, TNNI3K, TSSK2, AXL, ERBB3, FGFR1, MATK, ITK, CLK3, NTRK3, FLT4, ACVR1B, DCLK2, NTRK2, MAP4K4, ACVR2B, SGK3, MAP3K2, TYK2, CAMKK1, NEK11, KSR1, PRKCB, WNK4, SRPK1, STYK1, HCK, AURKC, BTK, PRKG2, MAP2K7, MAPK15, LYN, PRKX, JAK1, TP53RK, FBXW2, FBXO38, FBXO25, SKP2, TRIM56, KLHL38, FBXO24, FBXL3, FBXW11, WSB2, KBTBD4, FBXL2, FBXL12, KLHL6, ENC1, KCTD8, GAN, KLHL25, FBXL14, FBXW7, FBXO9, KLHL22, PRPF19, KLHL26, RAPSN, FBXO18, FBXL15, KLHL10, FBXL8, TRIM17, FBXL18, KLHL36, LNX1, RNF19B, ASB4, RNF10, BTRC, KLHL34, ARMC5, DET1, KLHL14, VPS18, FBXO28, FBXO17, RFWD3, FBXO27, FBXL13, ASB2, NHLRC1, SF3B3, KBTBD7, FBXO3, RAB40A, ANAPC2, AREL1, KLHL15, WWP1, PCGF1, HECTD3, TRIM49, KLHL1, TRIM10, KLHL23, TRIM2, ZBTB20, KLHL29, KLHL32, SH3RF2, LGALS3BP, ASB3, KLHL13, PCGF3, HERC6, RHOBTB1, FBXO40, FBXW5, KCNG1, SPSB3, TRIM36, ZBTB17, DTX4, ASB6, ZBTB49, MARCH9, LRSAM1, FBXO4, TRIM32, TNFAIP3, TRIM74, RCBTB2, RCBTB1, VPS41, ASB17, KCNA5, PCGF6, KCNS3, TRIM73, SPSB1, KCNA6, SOCS6, HERC4, TRIM41, TRIM7, G2E3, RNF111, RNF40, MDM4, FBXO34, FBXO10, TRIM37, RGS11, RGS6, PREB, ZBED4, RAG1, ZC3H7B, FOXD4L6, NR3C2, POGK, NR1H3, RGS7, PRDM1, STAT2, NR2C2, GTF2IRD2, DLX6, NR1I3, HP1BP3, SREBF1, NFRKB, KAT5, IRF2, TFDP3, TEAD2, C20orf194, LARP4B, ZNF74, SIM2, NR1I2, HMGA1, TBX22, BBX, CXXC1, DMRTA1, SETDB1, NFIC, SLFN11, ZNF215, TCF25, ISX, TADA2A, ATF3, THAP4, CEBPE, FOXP2, MKX, MAX, FOXM1, MAFG, TSSK3, RPS6KA5, HIPK4, MAPK4, YES1, BLK, SGK223, IRAK2, STK38, TSSK1B, PRKCE, NEK8, CAMK2G, DYRK1B, PDGFRB, PDIK1L, PRKCQ, TYRO3, RPS6KL1, PKN1, CDK3, DDR1, PRKCA, CDK18, GRK7, EPHA1, ILK, PRKCG, EPHA2, SRPK3, PIM3, TESK1, LIMK1, NUAK2, FGR, PRKCH, MAP4K1, MYLK3, RET, MAP3K9, CDK6, ALK, RPS6KB1, RPS6KC1, PRKAA2, BRAF, MAP3K5, RPS6KA2, STK38L, RPS6KA6, RPS6KA3, EPHA4, IRAK3, DMPK, CAMKV, CAMK1G, PIM2, BMX, STK32B, IGF1R, TAOK3, ROR2, PTK6, ERBB4, PASK, CDK14, MUSK, PTK2, PRKD1, STK32C, MAP4K2, IKBKE, AURKB, PTK2B, MINK1, NEK9, DAPK3, CAMKK2, AKT2, PAK6, CAMK4, PRKD2, RPS6KA1, CAMK2A, CAMK2B, CAMK2D, CLK2, CDH1, TOMM70A, IFIT1, ATF2, IQCB1, HSPA1B, GIGYF2, TUBB2B, SSBP1, TUBB, TUBB4B, DNAJA1, PDRG1, DNAJA2, TUBAL3, NOS2, AGO1, AGO2, METTL18, CAMKMT, METTL21B, METTL22, UBL4A, ILF3, FAM162A, MAP3K11, SLC12A3, PAN2, BIRC5, NPM1, SMG1, RAD52, IRF1, MMP2, DNAJA3, BAG3, PIK3C3, CAV1, RBCK1, TOMM40, LSM1, CERS2, KATNA1, KEAP1, CDKN2A, CKS2, CKS1B, AIPL1, GZMA, CAP1, MCM3, MCM5, MGEA5, PPP6R3, MAGED2, RHOBTB2, PRKACA, ADRBK1, CDK5, PRKCD, FKBP6, UNC45B, BRCA1, AURKA, CEP250, CEP57, CEP76, VHL, PSMD10, CDK1, CDC25C, PTGDS, PTGDR, HUWE1, FUS, NXF1, TRAF3IP2, MCF2, WDR76, AGO3, PCBP1, CDKL2, CDKL4, CDK13, RPS6KB2, HSPB1, AMBRA1, UNK, ATP5A1, CANX, DDOST, ATP5B, HSPE1, P4HB, SSR4, UQCRC2, PTEN, RAD51, NPHP4, HK2, NES, TERF1, TTC1, VARS, PRPF4B, U2AF2, COBLL1, SKIV2L2, ZMYM1, FAM103A1, WDR20, CRY2, ESRRB, MCM2, SNW1, CDC5L, RHOBTB3, XRCC1, EGLN1, TTK, EIF2S1, ATXN3, CRBN, UHRF1, WEE1, FLCN, FNIP2, AKT3, STK35, GBP2, ANKMY2, SLC9A1, LLGL1, RB1, FZR1, MCL1, CDKN1B, CYLD, DDX59, TRIM25, G3BP1, PRNP, SERPINB5, RRM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYH9_HSP90AA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMYH9P35579DB11638ArtenimolMyosin-9small moleculeapproved|investigational
TgeneHSP90AA1P07900DB00615RifabutinHeat shock protein HSP 90-alphasmall moleculeapproved|investigational
TgeneHSP90AA1P07900DB00716NedocromilHeat shock protein HSP 90-alphasmall moleculeapproved|investigational

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RelatedDiseases for MYH9_HSP90AA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYH9C0403445Fechtner syndrome (disorder)9UNIPROT
HgeneMYH9C0398641Epstein syndrome (disorder)7UNIPROT
HgeneMYH9C0340978May-Hegglin anomaly6UNIPROT
HgeneMYH9C0022661Kidney Failure, Chronic2CTD_human
HgeneMYH9C1854520SEBASTIAN SYNDROME2CTD_human;ORPHANET;UNIPROT
HgeneMYH9C0017668Focal glomerulosclerosis1CTD_human
HgeneMYH9C0020544Renal hypertension1CTD_human
HgeneMYH9C0027706Hereditary nephritis1CTD_human
HgeneMYH9C0036341Schizophrenia1PSYGENET
HgeneMYH9C1863659DEAFNESS, AUTOSOMAL DOMINANT 171UNIPROT
HgeneMYH9C2673482Increased susceptibility to schizophrenia1PSYGENET
TgeneHSP90AA1C0009178Cocaine withdrawal1PSYGENET
TgeneHSP90AA1C0011616Contact Dermatitis1CTD_human
TgeneHSP90AA1C0019693HIV Infections1CTD_human
TgeneHSP90AA1C0027627Neoplasm Metastasis1CTD_human
TgeneHSP90AA1C0041696Unipolar Depression1PSYGENET
TgeneHSP90AA1C0206180Ki-1+ Anaplastic Large Cell Lymphoma1CTD_human
TgeneHSP90AA1C0525045Mood Disorders1PSYGENET
TgeneHSP90AA1C1269683Major Depressive Disorder1PSYGENET
TgeneHSP90AA1C1458155Mammary Neoplasms1CTD_human