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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22979

FusionGeneSummary for MYH11_TYK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYH11_TYK2
Fusion gene ID: 22979
HgeneTgene
Gene symbol

MYH11

TYK2

Gene ID

4629

7297

Gene namemyosin heavy chain 11tyrosine kinase 2
SynonymsAAT4|FAA4|SMHC|SMMHCIMD35|JTK1
Cytomap

16p13.11

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionmyosin-11myosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth musclenon-receptor tyrosine-protein kinase TYK2
Modification date2018051920180522
UniProtAcc

P35749

P29597

Ensembl transtripts involved in fusion geneENST00000396324, ENST00000452625, 
ENST00000576790, ENST00000300036, 
ENST00000573908, 
ENST00000264818, 
ENST00000524462, ENST00000525621, 
ENST00000529370, ENST00000529422, 
Fusion gene scores* DoF score7 X 6 X 4=16842 X 7 X 17=4998
# samples 743
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(43/4998*10)=-3.53894233649724
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYH11 [Title/Abstract] AND TYK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-VP-A879-01AMYH11chr16

15796992

-TYK2chr19

10491352

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000396324ENST00000264818MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000396324ENST00000524462MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000396324ENST00000525621MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000396324ENST00000529370MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000396324ENST00000529422MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000452625ENST00000264818MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000452625ENST00000524462MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000452625ENST00000525621MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000452625ENST00000529370MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000452625ENST00000529422MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000576790ENST00000264818MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000576790ENST00000524462MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000576790ENST00000525621MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000576790ENST00000529370MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000576790ENST00000529422MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000300036ENST00000264818MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000300036ENST00000524462MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000300036ENST00000525621MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000300036ENST00000529370MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000300036ENST00000529422MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000573908ENST00000264818MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000573908ENST00000524462MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000573908ENST00000525621MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000573908ENST00000529370MYH11chr16

15796992

-TYK2chr19

10491352

-
intron-intronENST00000573908ENST00000529422MYH11chr16

15796992

-TYK2chr19

10491352

-

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FusionProtFeatures for MYH11_TYK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYH11

P35749

TYK2

P29597

Muscle contraction. Probably involved in intracellular signal transductionby being involved in the initiation of type I IFN signaling.Phosphorylates the interferon-alpha/beta receptor alpha chain.{ECO:0000269|PubMed:7526154}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYH11_TYK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYH11_TYK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYH11SLX1B, GRB2, DAXX, APC, YWHAQ, SP1, FBXO25, MYOC, SHC1, ACTA2, ACTB, DSTN, MYO1E, EIF3A, RPA1, RPA2, RPA3, LGR4, FAM96A, OVCA2, RWDD2B, MYO5A, SFN, C4BPA, CAPZB, FLNA, MYL6, RAD51, SVIL, YWHAE, ARPC5, ACTR3, RALBP1, POC1A, ASTE1, MED4, LRRC59, CGN, INF2, ARPC5L, TBC1D31, UBXN2A, PLBD2, TMEM189, ZNF746, MPP1, GDF9, COQ2, COX15, DLST, DNM1L, PARK7, PDHA1, SOAT1, SOD1, VDAC1TYK2GNB2L1, STAT1, PRMT5, XRCC5, VAV1, IFNAR1, CRKL, JAK1, TYK2, ELP2, IL13RA1, LYN, CBL, PTPN6, PLAUR, IL6ST, FYN, PTPN1, STAM2, GHR, IRS2, DNM2, TK1, SOCS1, KLF10, LNX1, PTAFR, EIF2AK2, HSP90AA1, JAK3, COPS5, FHL3, HNRNPK, TRAF4, KRT40, KHDRBS2, SIVA1, SHMT2, MOV10, NXF1, BAG2, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, DDX5, HNRNPH1, HSPB1, CEP170B, RAN, RUVBL1, RUVBL2, SLC2A1, TCP1, ALYREF, TRIM28, TUBA4A, WDR20, EFNB2, PIH1D1, TGFBR2, LRRC46, LPAR6, RNF13, ZNF333, MIER2, SIAH2, UBE2L6, LRP8, IFT43, PMEL, TNFRSF19, GMNN, IL4R, TMCO3, GPR156, CDH8, CD79A, TNFRSF13B, HAVCR2, PROSER2, LGALS3BP, C16orf71, MAS1, NLGN3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYH11_TYK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTYK2P29597DB08895TofacitinibNon-receptor tyrosine-protein kinase TYK2small moleculeapproved|investigational

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RelatedDiseases for MYH11_TYK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYH11C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneMYH11C0023479Acute myelomonocytic leukemia1CTD_human;ORPHANET
HgeneMYH11C1851504Aortic aneurysm, familial thoracic 41CTD_human;UNIPROT
TgeneTYK2C0003873Rheumatoid Arthritis1CTD_human
TgeneTYK2C0010346Crohn Disease1CTD_human
TgeneTYK2C0023892Biliary cirrhosis1CTD_human
TgeneTYK2C0026769Multiple Sclerosis1CTD_human
TgeneTYK2C0033860Psoriasis1CTD_human
TgeneTYK2C0041696Unipolar Depression1PSYGENET
TgeneTYK2C0236736Cocaine-Related Disorders1CTD_human
TgeneTYK2C0344315Depressed mood1PSYGENET
TgeneTYK2C1269683Major Depressive Disorder1PSYGENET
TgeneTYK2C1456784Paranoia1CTD_human