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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 22960

FusionGeneSummary for MYCBP2_SPPL2A

check button Fusion gene summary
Fusion gene informationFusion gene name: MYCBP2_SPPL2A
Fusion gene ID: 22960
HgeneTgene
Gene symbol

MYCBP2

SPPL2A

Gene ID

23077

84888

Gene nameMYC binding protein 2, E3 ubiquitin protein ligasesignal peptide peptidase like 2A
SynonymsMyc-bp2|PAM|PhrIMP3|PSL2
Cytomap

13q22.3

15q21.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Mycsignal peptide peptidase-like 2AIMP-3SPP-like 2Aintramembrane cleaving proteaseintramembrane protease 3presenilin-like protein 2
Modification date2018052320180523
UniProtAcc

O75592

Q8TCT8

Ensembl transtripts involved in fusion geneENST00000544440, ENST00000407578, 
ENST00000357337, ENST00000360084, 
ENST00000482517, 
ENST00000261854, 
ENST00000559293, 
Fusion gene scores* DoF score9 X 9 X 7=5672 X 2 X 2=8
# samples 92
** MAII scorelog2(9/567*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MYCBP2 [Title/Abstract] AND SPPL2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPPL2A

GO:0006509

membrane protein ectodomain proteolysis

16829951|17965014

TgeneSPPL2A

GO:0031293

membrane protein intracellular domain proteolysis

16829951|17557115

TgeneSPPL2A

GO:0033619

membrane protein proteolysis

2313285


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTHCATCGA-EM-A3O3-01AMYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000544440ENST00000261854MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
5CDS-intronENST00000544440ENST00000559293MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
Frame-shiftENST00000407578ENST00000261854MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
5CDS-intronENST00000407578ENST00000559293MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
In-frameENST00000357337ENST00000261854MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
5CDS-intronENST00000357337ENST00000559293MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
intron-3CDSENST00000360084ENST00000261854MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
intron-intronENST00000360084ENST00000559293MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
intron-3CDSENST00000482517ENST00000261854MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-
intron-intronENST00000482517ENST00000559293MYCBP2chr13

77661619

-SPPL2Achr15

51028937

-

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FusionProtFeatures for MYCBP2_SPPL2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYCBP2

O75592

SPPL2A

Q8TCT8

Atypical E3 ubiquitin-protein ligase which specificallymediates ubiquitination of threonine and serine residues on targetproteins, instead of ubiquitinating lysine residues(PubMed:29643511). Shows esterification activity towards boththreonine and serine, with a preference for threonine, and actsvia two essential catalytic cysteine residues that relay ubiquitinto its substrate via thioester intermediates (PubMed:29643511).Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3(PubMed:18308511, PubMed:29643511). Plays a key role in neuraldevelopment, probably by mediating ubiquitination of threonineresidues on target proteins (Probable). Involved in differentprocesses such as regulation of neurite outgrowth, synapticgrowth, synaptogenesis and axon degeneration (By similarity).Required for the formation of major central nervous system axontracts (By similarity). Required for proper axon growth byregulating axon navigation and axon branching: acts by regulatingthe subcellular location and stability of MAP3K12/DLK (Bysimilarity). Required for proper localization of retinogeniculateprojections but not for eye-specific segregation (By similarity).Regulates axon guidance in the olfactory system (By similarity).Involved in Wallerian axon degeneration, an evolutionarilyconserved process that drives the loss of damaged axons: acts bypromoting destabilization of NMNAT2, probably via ubiquitinationof NMNAT2 (By similarity). Catalyzes ubiquitination of threonineand/or serine residues on NMNAT2, consequences of threonine and/orserine ubiquitination are however unknown (PubMed:29643511).Regulates the internalization of TRPV1 in peripheral sensoryneurons (By similarity). May mediate ubiquitination and subsequentproteasomal degradation of TSC2/tuberin (PubMed:18308511).Independently of the E3 ubiquitin-protein ligase activity, alsoacts as a guanosine exchange factor (GEF) for RAN in neurons ofdorsal root ganglia (PubMed:26304119). May function as afacilitator or regulator of transcriptional activation by MYC(PubMed:9689053). {ECO:0000250|UniProtKB:Q7TPH6,ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:26304119,ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}. Intramembrane-cleaving aspartic protease (I-CLiP) thatcleaves type II membrane signal peptides in the hydrophobic planeof the membrane. Functions in FASLG, ITM2B and TNF processing(PubMed:16829952, PubMed:16829951, PubMed:17557115,PubMed:17965014). Catalyzes the intramembrane cleavage of theanchored fragment of shed TNF-alpha (TNF), which promotes therelease of the intracellular domain (ICD) for signaling to thenucleus (PubMed:16829952). Also responsible for the intramembranecleavage of Fas antigen ligand FASLG, which promotes the releaseof the intracellular FasL domain (FasL ICD) (PubMed:17557115). Mayplay a role in the regulation of innate and adaptive immunity(PubMed:16829952). Catalyzes the intramembrane cleavage of thesimian foamy virus envelope glycoprotein gp130 independently ofprior ectodomain shedding by furin or furin-like proproteinconvertase (PC)-mediated cleavage proteolysis (PubMed:23132852).{ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952,ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:17965014,ECO:0000269|PubMed:23132852}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYCBP2_SPPL2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MYCBP2_ENST00000357337_chr13_77661619_-_SPPL2A_ENST00000261854_chr15_51028937_-_3863aa
MPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSE
NLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSH
PSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAISAILTNNGS
HACQTIQVPTILNSLQRSVQAVLVGKIQIQDWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGH
IYNSTSRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEGQNILFTDGEYINQIAASRDDGFVVRIFATS
TEPVLQQELQLKLARKCLHACGISLFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITK
SPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAIY
SDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGM
HKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPG
VNIEEHLQLRQEEKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDC
ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPIL
DVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDS
EQEDLQGFGVCLDPVYDVIWRFRPNTRELWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQDL
KMGVASTEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDL
LAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRLPT
SDGSASKGKQQTSEPVHILKRSFARTVSVECFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIY
PVSATGKAVVEETSKLAECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQWACLCDLL
NCLDQDIQEANFKTSSSRLLAAVMSALCHTSVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSF
REVLEKMLVIVVLPVRNSLRRENELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTGNGSPDAIC
FSVDKPGIVVVGFSVYGGGGIHEYELEVLVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGS
RTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRASKDLLHRAL
AVDADDIPELLSSSSLFSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSS
HYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSGYGPKLTSVHENLNSWIELKKFSGSSGWPTM
VLVLPGNEALFSLETASDYVKDDKASFYGFKCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAAL
QVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTTIT
VQTKDQYGDVVHVPNMKVEVKAVPVSQKKMSLQQDQAKKPQRIPGSPAVTAASSNTDMTYGGLASPKLDVSYEPMIVKEARYIAITMMKV
YENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGLYTLHVTIDGIEIDAGLEVKVKDPPKGMIPPGTQLVKPKSEPQPNKV
RKFVAKDSAGLRIRSHPSLQSEQIGIVKVNGTITFIDEIHNDDGVWLRLNDETIKKYVPNMNGYTEAWCLSFNQHLGKSLLVPVDESKTN
TDDFFKDINSCCPQEATMQEQDMPFLRGGPGMYKVVKTGPSGHNIRSCPNLRGIPIGMLVLGNKVKAVGEVTNSEGTWVQLDQNSMVEFC
ESDEGEAWSLARDRGGNQYLRHEDEQALLDQNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKH
SRSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTLP
ANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRA
PSPHVVQENLHSEVVEVCTSSTLKTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANRHTRPKKEKSSFLF
KGDGSKPLEPAKQAMSPSVAECARAVFASFLWHEGIVHDAMACSSFLKFHPELSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALN
MFNIAPHGPDISKMGSINKNKVLSMLKEPPLHEKCEDGKTETTFEMSMHNTMKSKSPLPLTLQHLVAFWEDISLATIKAASQNMIFPSPG
SCAVLKKKECEKENKKSKKEKKKKEKAEVRPRGNLFGEMAQLAVGGPEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHF
CGGWAGNCGDGGIGGSTWYLVCDRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTMEAHQVIKANALFLLSLSSAAEPSILCYHPA
KPFQSQLPSVKEGISEDLPVKMPCLYLQTLARHHHENFVGYQDDNLFQDEMRYLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLE
TSPITDTDLAKRTVFQRSYSVVASEYDKQHSILPARVKAIPRRRVNSGDTEVGSSLLRHPSPELSRLISAHSSLSKGERNFQWPVLAFVI
QHHDLEGLEIAMKQALRKSACRVFAMEAFNWLLCNVIQTTSLHDILWHFVASLTPAPVEPEEEEDEENKTSKENSEQFMLXXQFSAXHQQ
XVCTTVLLHXFIRYHMDNARLHVVAKTWKXDLFFSLDCAXQXLLFGLCFEMKTGGLGFYRISWGLLSVXIXLKHXSCPTSSHVXYFXAFS
SSMMYFLFSXHHSSQRMVRVSWLNSQLDLLEIMKSCQXSSEYQNXSISQXXVCASCLFQYWVLETLLYQACXLHTVEDLMFRLVLLTYTM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MYCBP2_ENST00000357337_chr13_77661619_-_SPPL2A_ENST00000261854_chr15_51028937_-_11591nt
ATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTGCTG
TCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACACCCA
GCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTGAAGACAAGAAGCAAGTCTGAA
AACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTACTGTAATGTACGCCATTGCGTT
CTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCAGATAGTGATGAAGAAGAGGAA
TCCAAAGAGCCCCCTATCAAGCTTCCAAAGATTATTGAGGTTGGCCTTTGTGAAGTTTTTGAATTGATCAAAGAGACACGATTTTCTCAT
CCATCCCTGTGTCTCAGGAGTCTCCAAGCCCTGCTCAACGTGCTGCAGGGCCAGCAGCCAGAAGGCCTCCAGTCTGAGCCACCTGAGGTC
CTAGAGTCTCTCTTCCAGCTTCTTTTGGAAATCACCGTTCGAAGTACTGGGATGAATGACAGCACAGGACAGTCCTTAACAGCACTTTCC
TGTGCTTGCCTCTTTAGTCTGGTGGCTTCTTGGGGAGAAACAGGAAGGACACTTCAGGCCATCTCTGCTATCCTCACCAACAATGGAAGC
CATGCTTGCCAAACTATTCAGGTGCCAACAATTCTAAATTCGCTACAGAGAAGTGTACAAGCAGTTTTGGTGGGAAAAATTCAAATTCAG
GACTGGTTTAGTAATGGCATTAAGAAAGCAGCTTTAATGCACAAGTGGCCATTAAAAGAAATATCTGTTGATGAAGATGACCAATGTCTA
CTTCAGAATGATGGATTTTTTCTTTATCTATTATGCAAGGATGGATTATATAAAATAGGCTCTGGATACAGTGGAACAGTTAGGGGCCAT
ATATACAATTCTACATCCCGTATTAGAAACAGAAAAGAAAAAAAGTCTTGGTTAGGGTATGCTCAGGGTTATTTATTATATAGAGATGTG
AATAACCACAGCATGACAGCCATAAGGATAAGCCCTGAAACACTGGAGCAAGATGGTACTGTGATGTTACCAGATTGCCACACTGAAGGT
CAAAATATTTTATTCACTGATGGAGAATATATTAATCAGATAGCTGCTTCAAGAGATGATGGCTTTGTTGTCAGAATATTTGCCACAAGC
ACTGAACCTGTTCTACAGCAAGAATTGCAACTTAAACTGGCTAGAAAATGCTTACATGCCTGTGGTATCTCACTATTCGATCTGGAAAAG
GACTTGCATATTATAAGTACAGGATTTGATGAGGAGTCAGCAATTCTTGGTGCAGGACGAGAGTTTGCGCTAATGAAAACAGCAAATGGA
AAGATATATTACACTGGCAAATACCAGAGTCTTGGAATCAAACAAGGTGGTCCTTCAGCAGGAAAATGGGTTGAGCTACCAATTACAAAA
TCTCCAAAGATAGTACACTTCTCAGTTGGACACGATGGCTCTCACGCCCTTTTAGTTGCAGAAGATGGGAGCATATTCTTTACAGGATCT
GCTAGTAAAGGAGAAGATGGAGAATCAACTAAGAGCAGACGGCAATCCAAACCTTATAAACCTAAAAAGATAATTAAGATGGAAGGAAAG
ATTGTGGTATATACAGCCTGCAATAATGGAAGTAGTTCTGTTATTTCTAAAGATGGAGAACTCTACATGTTTGGAAAAGATGCCATTTAC
TCTGATAGTTCAAGTTTGGTAACTGATTTGAAGGGCCATTTTGTAACTCAGGTAGCTATGGGCAAAGCTCACACTTGTGTTTTAATGAAG
AATGGAGAGGTGTGGACATTTGGTGTAAATAATAAAGGACAGTGTGGACGAGATACTGGTGCCATGAACCAAGGTGGGAAAGGGTTTGGA
GTTGAAAATATGGCAACAGCAATGGATGAAGACCTGGAAGAAGAACTAGATGAAAAAGATGAGAAGTCTATGATGTGCCCTCCAGGCATG
CACAAATGGAAGCTGGAGCAGTGCATGGTTTGCACTGTCTGTGGAGACTGTACAGGTTATGGAGCCAGCTGTGTCAGTAGTGGACGGCCA
GACAGAGTCCCCGGAGGGATCTGTGGTTGTGGTTCCGGAGAATCTGGTTGTGCTGTGTGTGGATGTTGCAAGGCCTGTGCAAGAGAGTTA
GATGGTCAAGAGGCAAGACAAAGAGGAATTCTTGATGCAGTGAAAGAAATGATACCTTTAGATCTTCTTTTAGCTGTCCCAGTGCCCGGG
GTTAACATTGAAGAACACCTTCAGTTACGACAAGAAGAAAAACGGCAACGTGTAATCAGAAGGCACAGATTAGAGGAAGGAAGAGGCCCC
CTTGTATTTGCTGGTCCTATTTTTATGAACCATCGAGAACAGGCTCTAGCCAGACTCAGATCCCATCCAGCACAGCTAAAGCATAAACGG
GACAAGCACAAAGATGGAAGTGGAGAAAGAGGCGAAAAGGATGCAAGCAAAATCACAACATACCCTCCAGGCTCTGTGCGATTTGACTGT
GAGCTCCGGGCAGTCCAAGTCAGCTGTGGATTTCACCATTCAGTGGTTTTAATGGAAAATGGAGATGTCTATACATTTGGTTATGGGCAG
CATGGGCAGCTAGGACATGGAGATGTCAACTCCAGGGGATGTCCCACTCTTGTTCAAGCATTGCCAGGCCCTAGCACACAAGTCACTGCA
GGCAGCAACCATACGGCAGTACTTTTAATGGATGGACAGGTCTTCACATTTGGAAGTTTTTCTAAAGGACAACTGGGCAGACCAATTTTG
GATGTGCCATATTGGAATGCAAAGCCAGCTCCCATGCCTAACATTGGATCAAAATATGGAAGAAAAGCTACTTGGATAGGTGCAAGTGGG
GACCAAACTTTTTTACGAATTGATGAAGCACTTATTAATTCTCATGTACTTGCTACATCAGAAATTTTTGCCAGTAAACACATAATAGGC
TTGGTACCTGCTTCTATATCAGAACCTCCTCCATTTAAATGCCTTCTGATAAATAAAGTGGATGGGAGTTGTAAAACTTTTAATGACTCA
GAACAAGAGGATCTGCAAGGATTTGGTGTGTGTCTTGATCCTGTATATGATGTAATTTGGAGGTTTCGACCAAATACTAGAGAGCTGTGG
TGTTACAATGCGGTGGTTGCTGATGCCAGGCTTCCCTCTGCAGCAGACATGCAGTCCAGATGTAGTATCCTAAGTCCTGAACTTGCCTTA
CCAACAGGATCAAGGGCCCTCACTACCCGATCTCATGCAGCTTTGCACATTTTAGGTTGTCTTGATACCTTGGCAGCTATGCAGGACTTA
AAAATGGGTGTTGCAAGTACAGAGGAAGAGACTCAAGCAGTAATGAAGGTTTATTCTAAAGAAGATTATAGTGTGGTAAACAGGTTTGAA
AGTCATGGAGGAGGCTGGGGTTATTCTGCCCATTCAGTAGAAGCTATACGTTTCAGTGCCGACACTGATATTTTACTTGGTGGTCTTGGT
CTGTTTGGAGGTAGAGGAGAATATACTGCTAAAATTAAGCTGTTTGAATTGGGTCCTGATGGAGGAGATCATGAAACTGATGGTGACCTT
CTTGCAGAGACTGATGTATTGGCTTATGACTGTGCTGCTAGAGAAAAATATGCAATGATGTTTGATGAGCCTGTTCTCCTGCAAGCTGGG
TGGTGGTATGTGGCATGGGCCCGAGTGTCAGGACCCAGCAGTGACTGTGGATCTCATGGACAGGCATCTATTACCACAGATGATGGGGTT
GTTTTCCAGTTCAAGAGTTCAAAGAAATCAAATAATGGTACAGATGTTAATGCGGGTCAGATACCTCAGTTATTATACAGACTTCCAACC
AGTGATGGCAGTGCTTCAAAAGGCAAACAGCAAACCAGTGAACCTGTACACATTTTAAAGAGGTCTTTTGCAAGAACTGTCTCAGTGGAA
TGTTTTGAGTCATTGTTGAGTATTCTTCACTGGAGCTGGACCACCTTAGTCTTAGGAGTTGAAGAACTTAGAGGATTAAAAGGATTCCAG
TTCACAGCTACACTCCTAGATTTAGAGAGACTGCGCTTTGTGGGTACCTGTTGTCTGAGGTTATTGCGTGTCTATACCTGTGAAATTTAC
CCAGTGTCAGCTACAGGAAAAGCAGTTGTAGAAGAAACTAGCAAATTAGCAGAGTGTATTGGAAAAACCAGAACTTTGTTAAGAAAAATT
TTATCAGAAGGAGTTGATCACTGCATGGTGAAATTGGATAATGATCCTCAAGGATATCTCAGTCAACCCTTGAGTCTTCTAGAAGCTGTC
CTTCAGGAATGTCATAATACTTTCACTGCCTGCTTTCATTCTTTCTACCCAACTCCTGCCTTACAGTGGGCTTGCCTTTGTGATCTGCTG
AATTGTTTGGATCAGGATATCCAAGAAGCAAACTTCAAGACATCAAGTAGCCGACTCCTTGCAGCTGTTATGTCAGCTCTGTGTCACACG
TCTGTTAAGCTGACTTCCATCTTCCCGATTGCGTATGATGGAGAAGTATTACTACGATCAATTGTTAAACAAGTTAGTACAGAGAACGAC
TCAACACTAGTTCATCGTTTTCCCCTTTTGGTGGCACATATGGAAAAACTCAGCCAGAGTGAAGAGAATATCTCAGGGATGACAAGCTTC
CGTGAAGTTCTGGAGAAAATGCTGGTCATTGTTGTGCTACCAGTCAGGAACAGCCTGAGGAGAGAAAATGAACTCTTCTCCTCCCACCTC
GTCTCTAACACCTGTGGATTACTGGCCAGCATTGTCAGTGAACTGACAGCGTCAGCCCTGGGATCTGAGGTTGATGGACTTAATTCTCTT
CACTCTGTAAAAGCTAGTGCTAACCGATTTACAAAAACAAGTCAGGGCAGAAGTTGGAACACTGGGAACGGGTCCCCTGATGCAATCTGT
TTTTCAGTAGACAAACCTGGAATAGTTGTGGTTGGTTTCTCTGTCTATGGAGGAGGTGGAATTCATGAATATGAATTAGAGGTGTTGGTT
GATGATAGTGAACATGCAGGAGATTCAACTCATTCCCACAGATGGACATCTCTGGAATTAGTGAAAGGAACGTACACAACGGATGACTCA
CCCAGTGATATAGCTGAGATCAGACTTGACAAAGTGGTTCCTTTAAAGGAAAATGTTAAATATGCTGTGCGCTTGAGGAACTATGGAAGC
CGTACAGCCAATGGAGATGGAGGAATGACCACAGTTCAGTGCCCTGATGGTGTGACATTCACATTCAGCACGTGCAGCTTGAGCAGTAAC
GGCACAAACCAAACCAGAGGACAGATCCCACAGATACTCTACTATAGGAGTGAATTTGATGGAGATTTACAATCCCAACTTCTGAGTAAA
GCCAATGAAGAAGATAAAAACTGTAGCAGAGCATTGTCTGTTGTAAGCACTGTCGTTCGAGCCTCTAAGGACCTCCTGCACAGAGCTCTT
GCTGTGGATGCTGATGACATTCCAGAACTGCTGAGTTCTTCCAGTCTGTTTTCCATGCTGCTCCCCCTTATTATAGCCTACATAGGACCA
GTAGCTGCTGCTATTCCCAAGGTGGCTGTAGAAGTCTTTGGCCTTGTCCAACAATTGCTTCCGTCAGTTGCCATTTTGAATCAGAAGTAT
GCACCGCCTGCCTTCAACCCTAATCAGTCGACAGATAGCACCACAGGAAACCAGCCTGAACAGGGCCTCTCTGCTTGTACAACCTCCAGT
CACTATGCTGTCATAGAGAGTGAGCACCCGTATAAACCTGCCTGTGTGATGCATTACAAGGTGACATTCCCAGAATGTGTGAGGTGGATG
ACAATCGAATTTGACCCTCAGTGTGGTACTGCACAGTCAGAAGATGTCCTTCGTTTGTTGATTCCTGTCAGAACTGTTCAGAATTCAGGA
TATGGACCAAAATTGACATCTGTTCATGAAAATCTTAATTCATGGATAGAATTAAAGAAATTTTCAGGATCCTCTGGGTGGCCTACTATG
GTTTTGGTGTTGCCAGGAAATGAGGCCCTTTTTTCATTGGAGACTGCATCAGATTATGTGAAAGATGACAAAGCTTCTTTCTATGGTTTT
AAGTGTTTTGCAATTGGATATGAATTTAGCCCTGGACCTGATGAGGGAGTCATCCAATTGGAAAAAGAATTAGCCAATCTTGGTGGGGTT
TGTGCAGCAGCTCTGATGAAGAAGGACCTAGCACTTCCTATTGGTAATGAATTAGAAGAAGACCTTGAAATTCTTGAGGAGGCTGCATTG
CAGGTGTGCAAAACCCATTCTGGAATTCTTGGAAAGGGTCTAGCTCTTTCTCATTCACCAACTATATTAGAAGCACTTGAGGGAAATTTA
CCACTCCAAATCCAAAGCAATGAACAGTCTTTTCTGGATGATTTTATTGCCTGTGTCCCAGGATCAAGTGGTGGAAGGCTTGCAAGGTGG
CTTCAGCCAGATTCATATGCGGATCCTCAGAAAACATCTTTGATCCTGAATAAGGATGATATTCGTTGTGGTTGGCCTACCACCATAACT
GTTCAAACAAAAGACCAGTATGGGGATGTGGTACATGTTCCCAATATGAAGGTGGAAGTGAAAGCTGTCCCTGTTTCTCAGAAAAAAATG
TCTTTACAACAAGATCAAGCAAAGAAACCTCAAAGGATTCCTGGCAGTCCTGCAGTAACAGCTGCATCTTCTAATACTGACATGACTTAT
GGAGGGCTGGCATCACCAAAGCTAGATGTTTCATATGAACCAATGATAGTGAAGGAAGCTCGATATATTGCCATAACAATGATGAAGGTT
TATGAAAATTATTCATTTGAAGAACTACGTTTTGCATCACCAACTCCTAAGAGACCCAGTGAGAATATGCTGATCCGTGTCAATAATGAT
GGGACTTATTGTGCAAATTGGACTCCAGGGGCTATTGGACTCTACACTCTTCATGTTACCATTGATGGCATTGAAATCGATGCTGGTCTG
GAAGTAAAAGTAAAAGACCCACCAAAAGGGATGATACCACCAGGAACTCAGTTGGTCAAACCAAAGTCTGAACCTCAGCCTAATAAGGTT
CGAAAATTTGTGGCCAAGGACAGTGCGGGGCTTCGCATCCGTAGCCACCCTTCCCTTCAGAGTGAGCAGATAGGCATAGTGAAAGTCAAT
GGAACTATCACTTTTATTGATGAGATCCATAATGATGATGGTGTGTGGCTGAGGCTGAATGATGAGACAATAAAGAAGTATGTCCCTAAC
ATGAATGGTTACACTGAAGCCTGGTGCCTCTCTTTTAATCAACATCTTGGCAAGAGTCTTCTGGTCCCTGTTGACGAATCTAAAACTAAT
ACTGATGACTTTTTCAAAGACATAAACTCCTGCTGCCCACAGGAAGCAACAATGCAAGAACAAGATATGCCATTCTTGCGAGGAGGGCCA
GGCATGTACAAGGTAGTGAAGACGGGACCTTCAGGTCACAACATCAGAAGCTGCCCTAACCTTAGAGGTATCCCAATTGGAATGTTAGTT
CTGGGAAACAAAGTCAAAGCAGTGGGAGAGGTAACCAATTCTGAAGGGACATGGGTGCAACTGGATCAGAACAGCATGGTAGAGTTCTGT
GAGAGTGATGAAGGAGAGGCATGGTCCTTAGCTAGAGACAGAGGCGGAAACCAGTACCTCCGACATGAAGATGAACAAGCTCTTCTGGAT
CAGAATTCTCAAACTCCTCCTCCAAGCCCTTTCTCAGTGCAAGCTTTTAATAAAGGGGCAAGTTGCAGTGCCCAAGGATTTGATTATGGA
CTCGGAAATAGCAAAGGTGATCGAGGAAACATCTCAACATCTTCTAAACCAGCCTCTACATCAGGAAAATCAGAGCTGTCCTCTAAACAC
AGCAGATCGCTTAAACCTGATGGACGTATGAGCCGGACTACTGCTGATCAGAAGAAGCCAAGGGGCACAGAAAGTTTATCTGCTAGTGAA
TCCCTCATCTTAAAATCTGATGCTGCAAAGTTGAGGTCAGATTCCCACAGTAGGTCATTATCCCCCAACCATAACACCTTGCAGACATTG
AAATCTGATGGGAGGATGCCTTCTAGCTCCAGAGCTGAATCCCCAGGACCAGGTTCTCGGTTGTCATCTCCTAAGCCAAAGACTCTCCCA
GCCAATAGGTCTAGCCCATCGGGTGCTAGTTCTCCACGCTCCTCCTCACCACATGATAAAAATCTACCTCAAAAAAGTACTGCTCCTGTT
AAGACAAAGCTTGATCCTCCTCGGGAACGTTCTAAATCAGACTCTTACACACTTGATCCAGATACCCTCCGCAAGAAGAAAATGCCCCTC
ACAGAACCTTTGAGAGGACGGTCAACGTCACCAAAACCAAAATCAGTACCAAAGGATTCTACAGATTCCCCTGGATCTGAAAATAGAGCT
CCCTCTCCCCATGTGGTACAGGAAAACCTCCACAGTGAGGTGGTCGAAGTCTGCACCTCAAGTACTTTAAAAACAAATAGTCTAACAGAC
AGCACCTGCGATGACAGCAGTGAATTTAAGAGTGTGGATGAAGGTTCAAATAAAGTTCATTTTAGCATTGGAAAAGCACCACTGAAAGAT
GAACAGGAAATGAGAGCATCTCCCAAAATAAGTCGAAAATGTGCTAATAGACACACCAGGCCCAAAAAAGAAAAATCGAGTTTTCTTTTC
AAAGGAGATGGATCCAAGCCTTTAGAGCCAGCCAAGCAAGCCATGTCTCCTTCTGTGGCCGAATGTGCCAGAGCTGTGTTTGCTTCCTTC
CTCTGGCATGAAGGCATAGTACATGATGCAATGGCTTGTTCTTCTTTCCTAAAGTTTCATCCTGAACTTTCCAAAGAACATGCTCCTATA
AGGAGTAGTTTAAATAGCCAACAACCTACAGAGGAAAAAGAAACCAAGTTAAAAAATAGACATTCATTAGAAATATCATCTGCACTGAAT
ATGTTTAATATTGCACCCCATGGACCAGATATATCTAAGATGGGTAGCATCAACAAAAACAAGGTATTGTCTATGCTTAAGGAACCACCT
CTGCATGAAAAATGTGAGGATGGGAAAACCGAGACCACTTTTGAAATGTCCATGCATAACACAATGAAGTCTAAGTCTCCTCTTCCCTTA
ACTTTACAACATTTAGTGGCTTTTTGGGAAGACATCTCTTTGGCTACTATCAAAGCTGCTTCCCAGAATATGATTTTTCCAAGTCCTGGT
TCCTGTGCAGTTCTTAAAAAGAAAGAGTGTGAGAAAGAGAATAAGAAGTCCAAAAAGGAAAAAAAGAAAAAAGAAAAGGCAGAAGTTAGG
CCCAGGGGTAATTTGTTTGGAGAGATGGCCCAGCTGGCAGTAGGAGGACCAGAGAAAGATACCATCTGTGAACTGTGTGGGGAGTCACAT
CCATACCCGGTGACCTATCACATGAGACAAGCTCACCCAGGTTGTGGCCGATATGCTGGTGGACAAGGTTACAATAGCATTGGGCATTTT
TGTGGAGGATGGGCTGGTAACTGTGGTGATGGTGGCATAGGAGGAAGCACTTGGTATCTGGTATGTGATCGCTGTAGAGAAAAATACCTC
CGCGAAAAACAGGCTGCTGCAAGGGAGAAGGTCAAACAATCTAGGAGAAAACCAATGCAAGTCAAGACCCCTCGTGCCTTGCCCACCATG
GAAGCTCACCAGGTGATTAAAGCCAATGCACTCTTCCTGCTGTCCCTGAGCAGTGCAGCAGAACCGAGCATTCTGTGTTACCATCCTGCA
AAGCCATTCCAATCTCAGTTGCCCAGTGTAAAAGAAGGCATTTCTGAGGATCTTCCTGTGAAAATGCCTTGTCTCTACCTGCAGACATTA
GCTAGGCATCATCATGAAAATTTTGTGGGCTATCAAGATGACAATCTATTCCAGGATGAAATGAGATATCTACGTTCAACATCTGTACCT
GCCCCGTATATATCAGTAACTCCTGATGCAAGTCCTAATGTATTTGAAGAGCCAGAGAGCAATATGAAGTCTATGCCACCAAGTTTAGAA
ACCAGTCCCATAACTGATACTGATCTTGCAAAGAGAACTGTCTTCCAAAGATCATACTCAGTTGTTGCTTCCGAATATGATAAACAACAC
TCCATTTTACCTGCACGAGTTAAAGCTATTCCTAGAAGAAGAGTTAACAGTGGAGACACTGAAGTTGGTTCTTCCCTTTTGAGACATCCG
TCTCCTGAGCTTTCTCGGCTAATCTCAGCCCACAGCTCTCTTTCTAAAGGAGAACGAAATTTCCAGTGGCCAGTTTTAGCTTTTGTTATA
CAACATCATGATCTAGAAGGTCTTGAAATAGCAATGAAACAGGCCCTAAGGAAATCTGCTTGTCGAGTTTTTGCTATGGAGGCTTTCAAC
TGGCTTCTGTGTAATGTCATCCAAACCACTTCTCTCCATGATATTCTGTGGCATTTTGTGGCATCACTGACTCCTGCACCAGTGGAACCA
GAGGAAGAAGAGGATGAAGAAAATAAAACAAGCAAAGAAAATTCAGAACAATTTATGTTATGATAGCAATTTTCTGCATAGCATCAGCAA
TGAGTCTGTACAACTGTCTTGCTGCACTAATTCATAAGATACCATATGGACAATGCACGATTGCATGTCGTGGCAAAAACATGGAAGTGA
GACTTATTTTTCTCTCTGGACTGTGCATAGCAGTAGCTGTTGTTTGGGCTGTGTTTCGAAATGAAGACAGGTGGGCTTGGATTTTACAGG
ATATCTTGGGGATTGCTTTCTGTCTGAATTTAATTAAAACACTGAAGTTGCCCAACTTCAAGTCATGTGTGATACTTCTAGGCCTTCTCC
TCCTCTATGATGTATTTTTTGTTTTCATAACACCATTCATCACAAAGAATGGTGAGAGTATCATGGTTGAACTCGCAGCTGGACCTTTTG
GAAATAATGAAAAGTTGCCAGTAGTCATCAGAGTACCAAAACTGATCTATTTCTCAGTAATGAGTGTGTGCCTCATGCCTGTTTCAATAT
TGGGTTTTGGAGACATTATTGTACCAGGCCTGTTGATTGCATACTGTAGAAGATTTGATGTTCAGACTGGTTCTTCTTACATATACTATG
TTTCGTCTACAGTTGCCTATGCTATTGGCATGATACTTACATTTGTTGTTCTGGTGCTGATGAAAAAGGGGCAACCTGCTCTCCTCTATT
TAGTACCTTGCACACTTATTACTGCCTCAGTTGTTGCCTGGAGACGTAAGGAAATGAAAAAGTTCTGGAAAGGTAACAGCTATCAGATGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MYCBP2_ENST00000357337_chr13_77661619_-_SPPL2A_ENST00000261854_chr15_51028937_-_12175nt
GGCGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGCCGGGGGCGCTG
TTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTG
CTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACAC
CCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTGAAGACAAGAAGCAAGTCT
GAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTACTGTAATGTACGCCATTGC
GTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCAGATAGTGATGAAGAAGAG
GAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGATTATTGAGGTTGGCCTTTGTGAAGTTTTTGAATTGATCAAAGAGACACGATTTTCT
CATCCATCCCTGTGTCTCAGGAGTCTCCAAGCCCTGCTCAACGTGCTGCAGGGCCAGCAGCCAGAAGGCCTCCAGTCTGAGCCACCTGAG
GTCCTAGAGTCTCTCTTCCAGCTTCTTTTGGAAATCACCGTTCGAAGTACTGGGATGAATGACAGCACAGGACAGTCCTTAACAGCACTT
TCCTGTGCTTGCCTCTTTAGTCTGGTGGCTTCTTGGGGAGAAACAGGAAGGACACTTCAGGCCATCTCTGCTATCCTCACCAACAATGGA
AGCCATGCTTGCCAAACTATTCAGGTGCCAACAATTCTAAATTCGCTACAGAGAAGTGTACAAGCAGTTTTGGTGGGAAAAATTCAAATT
CAGGACTGGTTTAGTAATGGCATTAAGAAAGCAGCTTTAATGCACAAGTGGCCATTAAAAGAAATATCTGTTGATGAAGATGACCAATGT
CTACTTCAGAATGATGGATTTTTTCTTTATCTATTATGCAAGGATGGATTATATAAAATAGGCTCTGGATACAGTGGAACAGTTAGGGGC
CATATATACAATTCTACATCCCGTATTAGAAACAGAAAAGAAAAAAAGTCTTGGTTAGGGTATGCTCAGGGTTATTTATTATATAGAGAT
GTGAATAACCACAGCATGACAGCCATAAGGATAAGCCCTGAAACACTGGAGCAAGATGGTACTGTGATGTTACCAGATTGCCACACTGAA
GGTCAAAATATTTTATTCACTGATGGAGAATATATTAATCAGATAGCTGCTTCAAGAGATGATGGCTTTGTTGTCAGAATATTTGCCACA
AGCACTGAACCTGTTCTACAGCAAGAATTGCAACTTAAACTGGCTAGAAAATGCTTACATGCCTGTGGTATCTCACTATTCGATCTGGAA
AAGGACTTGCATATTATAAGTACAGGATTTGATGAGGAGTCAGCAATTCTTGGTGCAGGACGAGAGTTTGCGCTAATGAAAACAGCAAAT
GGAAAGATATATTACACTGGCAAATACCAGAGTCTTGGAATCAAACAAGGTGGTCCTTCAGCAGGAAAATGGGTTGAGCTACCAATTACA
AAATCTCCAAAGATAGTACACTTCTCAGTTGGACACGATGGCTCTCACGCCCTTTTAGTTGCAGAAGATGGGAGCATATTCTTTACAGGA
TCTGCTAGTAAAGGAGAAGATGGAGAATCAACTAAGAGCAGACGGCAATCCAAACCTTATAAACCTAAAAAGATAATTAAGATGGAAGGA
AAGATTGTGGTATATACAGCCTGCAATAATGGAAGTAGTTCTGTTATTTCTAAAGATGGAGAACTCTACATGTTTGGAAAAGATGCCATT
TACTCTGATAGTTCAAGTTTGGTAACTGATTTGAAGGGCCATTTTGTAACTCAGGTAGCTATGGGCAAAGCTCACACTTGTGTTTTAATG
AAGAATGGAGAGGTGTGGACATTTGGTGTAAATAATAAAGGACAGTGTGGACGAGATACTGGTGCCATGAACCAAGGTGGGAAAGGGTTT
GGAGTTGAAAATATGGCAACAGCAATGGATGAAGACCTGGAAGAAGAACTAGATGAAAAAGATGAGAAGTCTATGATGTGCCCTCCAGGC
ATGCACAAATGGAAGCTGGAGCAGTGCATGGTTTGCACTGTCTGTGGAGACTGTACAGGTTATGGAGCCAGCTGTGTCAGTAGTGGACGG
CCAGACAGAGTCCCCGGAGGGATCTGTGGTTGTGGTTCCGGAGAATCTGGTTGTGCTGTGTGTGGATGTTGCAAGGCCTGTGCAAGAGAG
TTAGATGGTCAAGAGGCAAGACAAAGAGGAATTCTTGATGCAGTGAAAGAAATGATACCTTTAGATCTTCTTTTAGCTGTCCCAGTGCCC
GGGGTTAACATTGAAGAACACCTTCAGTTACGACAAGAAGAAAAACGGCAACGTGTAATCAGAAGGCACAGATTAGAGGAAGGAAGAGGC
CCCCTTGTATTTGCTGGTCCTATTTTTATGAACCATCGAGAACAGGCTCTAGCCAGACTCAGATCCCATCCAGCACAGCTAAAGCATAAA
CGGGACAAGCACAAAGATGGAAGTGGAGAAAGAGGCGAAAAGGATGCAAGCAAAATCACAACATACCCTCCAGGCTCTGTGCGATTTGAC
TGTGAGCTCCGGGCAGTCCAAGTCAGCTGTGGATTTCACCATTCAGTGGTTTTAATGGAAAATGGAGATGTCTATACATTTGGTTATGGG
CAGCATGGGCAGCTAGGACATGGAGATGTCAACTCCAGGGGATGTCCCACTCTTGTTCAAGCATTGCCAGGCCCTAGCACACAAGTCACT
GCAGGCAGCAACCATACGGCAGTACTTTTAATGGATGGACAGGTCTTCACATTTGGAAGTTTTTCTAAAGGACAACTGGGCAGACCAATT
TTGGATGTGCCATATTGGAATGCAAAGCCAGCTCCCATGCCTAACATTGGATCAAAATATGGAAGAAAAGCTACTTGGATAGGTGCAAGT
GGGGACCAAACTTTTTTACGAATTGATGAAGCACTTATTAATTCTCATGTACTTGCTACATCAGAAATTTTTGCCAGTAAACACATAATA
GGCTTGGTACCTGCTTCTATATCAGAACCTCCTCCATTTAAATGCCTTCTGATAAATAAAGTGGATGGGAGTTGTAAAACTTTTAATGAC
TCAGAACAAGAGGATCTGCAAGGATTTGGTGTGTGTCTTGATCCTGTATATGATGTAATTTGGAGGTTTCGACCAAATACTAGAGAGCTG
TGGTGTTACAATGCGGTGGTTGCTGATGCCAGGCTTCCCTCTGCAGCAGACATGCAGTCCAGATGTAGTATCCTAAGTCCTGAACTTGCC
TTACCAACAGGATCAAGGGCCCTCACTACCCGATCTCATGCAGCTTTGCACATTTTAGGTTGTCTTGATACCTTGGCAGCTATGCAGGAC
TTAAAAATGGGTGTTGCAAGTACAGAGGAAGAGACTCAAGCAGTAATGAAGGTTTATTCTAAAGAAGATTATAGTGTGGTAAACAGGTTT
GAAAGTCATGGAGGAGGCTGGGGTTATTCTGCCCATTCAGTAGAAGCTATACGTTTCAGTGCCGACACTGATATTTTACTTGGTGGTCTT
GGTCTGTTTGGAGGTAGAGGAGAATATACTGCTAAAATTAAGCTGTTTGAATTGGGTCCTGATGGAGGAGATCATGAAACTGATGGTGAC
CTTCTTGCAGAGACTGATGTATTGGCTTATGACTGTGCTGCTAGAGAAAAATATGCAATGATGTTTGATGAGCCTGTTCTCCTGCAAGCT
GGGTGGTGGTATGTGGCATGGGCCCGAGTGTCAGGACCCAGCAGTGACTGTGGATCTCATGGACAGGCATCTATTACCACAGATGATGGG
GTTGTTTTCCAGTTCAAGAGTTCAAAGAAATCAAATAATGGTACAGATGTTAATGCGGGTCAGATACCTCAGTTATTATACAGACTTCCA
ACCAGTGATGGCAGTGCTTCAAAAGGCAAACAGCAAACCAGTGAACCTGTACACATTTTAAAGAGGTCTTTTGCAAGAACTGTCTCAGTG
GAATGTTTTGAGTCATTGTTGAGTATTCTTCACTGGAGCTGGACCACCTTAGTCTTAGGAGTTGAAGAACTTAGAGGATTAAAAGGATTC
CAGTTCACAGCTACACTCCTAGATTTAGAGAGACTGCGCTTTGTGGGTACCTGTTGTCTGAGGTTATTGCGTGTCTATACCTGTGAAATT
TACCCAGTGTCAGCTACAGGAAAAGCAGTTGTAGAAGAAACTAGCAAATTAGCAGAGTGTATTGGAAAAACCAGAACTTTGTTAAGAAAA
ATTTTATCAGAAGGAGTTGATCACTGCATGGTGAAATTGGATAATGATCCTCAAGGATATCTCAGTCAACCCTTGAGTCTTCTAGAAGCT
GTCCTTCAGGAATGTCATAATACTTTCACTGCCTGCTTTCATTCTTTCTACCCAACTCCTGCCTTACAGTGGGCTTGCCTTTGTGATCTG
CTGAATTGTTTGGATCAGGATATCCAAGAAGCAAACTTCAAGACATCAAGTAGCCGACTCCTTGCAGCTGTTATGTCAGCTCTGTGTCAC
ACGTCTGTTAAGCTGACTTCCATCTTCCCGATTGCGTATGATGGAGAAGTATTACTACGATCAATTGTTAAACAAGTTAGTACAGAGAAC
GACTCAACACTAGTTCATCGTTTTCCCCTTTTGGTGGCACATATGGAAAAACTCAGCCAGAGTGAAGAGAATATCTCAGGGATGACAAGC
TTCCGTGAAGTTCTGGAGAAAATGCTGGTCATTGTTGTGCTACCAGTCAGGAACAGCCTGAGGAGAGAAAATGAACTCTTCTCCTCCCAC
CTCGTCTCTAACACCTGTGGATTACTGGCCAGCATTGTCAGTGAACTGACAGCGTCAGCCCTGGGATCTGAGGTTGATGGACTTAATTCT
CTTCACTCTGTAAAAGCTAGTGCTAACCGATTTACAAAAACAAGTCAGGGCAGAAGTTGGAACACTGGGAACGGGTCCCCTGATGCAATC
TGTTTTTCAGTAGACAAACCTGGAATAGTTGTGGTTGGTTTCTCTGTCTATGGAGGAGGTGGAATTCATGAATATGAATTAGAGGTGTTG
GTTGATGATAGTGAACATGCAGGAGATTCAACTCATTCCCACAGATGGACATCTCTGGAATTAGTGAAAGGAACGTACACAACGGATGAC
TCACCCAGTGATATAGCTGAGATCAGACTTGACAAAGTGGTTCCTTTAAAGGAAAATGTTAAATATGCTGTGCGCTTGAGGAACTATGGA
AGCCGTACAGCCAATGGAGATGGAGGAATGACCACAGTTCAGTGCCCTGATGGTGTGACATTCACATTCAGCACGTGCAGCTTGAGCAGT
AACGGCACAAACCAAACCAGAGGACAGATCCCACAGATACTCTACTATAGGAGTGAATTTGATGGAGATTTACAATCCCAACTTCTGAGT
AAAGCCAATGAAGAAGATAAAAACTGTAGCAGAGCATTGTCTGTTGTAAGCACTGTCGTTCGAGCCTCTAAGGACCTCCTGCACAGAGCT
CTTGCTGTGGATGCTGATGACATTCCAGAACTGCTGAGTTCTTCCAGTCTGTTTTCCATGCTGCTCCCCCTTATTATAGCCTACATAGGA
CCAGTAGCTGCTGCTATTCCCAAGGTGGCTGTAGAAGTCTTTGGCCTTGTCCAACAATTGCTTCCGTCAGTTGCCATTTTGAATCAGAAG
TATGCACCGCCTGCCTTCAACCCTAATCAGTCGACAGATAGCACCACAGGAAACCAGCCTGAACAGGGCCTCTCTGCTTGTACAACCTCC
AGTCACTATGCTGTCATAGAGAGTGAGCACCCGTATAAACCTGCCTGTGTGATGCATTACAAGGTGACATTCCCAGAATGTGTGAGGTGG
ATGACAATCGAATTTGACCCTCAGTGTGGTACTGCACAGTCAGAAGATGTCCTTCGTTTGTTGATTCCTGTCAGAACTGTTCAGAATTCA
GGATATGGACCAAAATTGACATCTGTTCATGAAAATCTTAATTCATGGATAGAATTAAAGAAATTTTCAGGATCCTCTGGGTGGCCTACT
ATGGTTTTGGTGTTGCCAGGAAATGAGGCCCTTTTTTCATTGGAGACTGCATCAGATTATGTGAAAGATGACAAAGCTTCTTTCTATGGT
TTTAAGTGTTTTGCAATTGGATATGAATTTAGCCCTGGACCTGATGAGGGAGTCATCCAATTGGAAAAAGAATTAGCCAATCTTGGTGGG
GTTTGTGCAGCAGCTCTGATGAAGAAGGACCTAGCACTTCCTATTGGTAATGAATTAGAAGAAGACCTTGAAATTCTTGAGGAGGCTGCA
TTGCAGGTGTGCAAAACCCATTCTGGAATTCTTGGAAAGGGTCTAGCTCTTTCTCATTCACCAACTATATTAGAAGCACTTGAGGGAAAT
TTACCACTCCAAATCCAAAGCAATGAACAGTCTTTTCTGGATGATTTTATTGCCTGTGTCCCAGGATCAAGTGGTGGAAGGCTTGCAAGG
TGGCTTCAGCCAGATTCATATGCGGATCCTCAGAAAACATCTTTGATCCTGAATAAGGATGATATTCGTTGTGGTTGGCCTACCACCATA
ACTGTTCAAACAAAAGACCAGTATGGGGATGTGGTACATGTTCCCAATATGAAGGTGGAAGTGAAAGCTGTCCCTGTTTCTCAGAAAAAA
ATGTCTTTACAACAAGATCAAGCAAAGAAACCTCAAAGGATTCCTGGCAGTCCTGCAGTAACAGCTGCATCTTCTAATACTGACATGACT
TATGGAGGGCTGGCATCACCAAAGCTAGATGTTTCATATGAACCAATGATAGTGAAGGAAGCTCGATATATTGCCATAACAATGATGAAG
GTTTATGAAAATTATTCATTTGAAGAACTACGTTTTGCATCACCAACTCCTAAGAGACCCAGTGAGAATATGCTGATCCGTGTCAATAAT
GATGGGACTTATTGTGCAAATTGGACTCCAGGGGCTATTGGACTCTACACTCTTCATGTTACCATTGATGGCATTGAAATCGATGCTGGT
CTGGAAGTAAAAGTAAAAGACCCACCAAAAGGGATGATACCACCAGGAACTCAGTTGGTCAAACCAAAGTCTGAACCTCAGCCTAATAAG
GTTCGAAAATTTGTGGCCAAGGACAGTGCGGGGCTTCGCATCCGTAGCCACCCTTCCCTTCAGAGTGAGCAGATAGGCATAGTGAAAGTC
AATGGAACTATCACTTTTATTGATGAGATCCATAATGATGATGGTGTGTGGCTGAGGCTGAATGATGAGACAATAAAGAAGTATGTCCCT
AACATGAATGGTTACACTGAAGCCTGGTGCCTCTCTTTTAATCAACATCTTGGCAAGAGTCTTCTGGTCCCTGTTGACGAATCTAAAACT
AATACTGATGACTTTTTCAAAGACATAAACTCCTGCTGCCCACAGGAAGCAACAATGCAAGAACAAGATATGCCATTCTTGCGAGGAGGG
CCAGGCATGTACAAGGTAGTGAAGACGGGACCTTCAGGTCACAACATCAGAAGCTGCCCTAACCTTAGAGGTATCCCAATTGGAATGTTA
GTTCTGGGAAACAAAGTCAAAGCAGTGGGAGAGGTAACCAATTCTGAAGGGACATGGGTGCAACTGGATCAGAACAGCATGGTAGAGTTC
TGTGAGAGTGATGAAGGAGAGGCATGGTCCTTAGCTAGAGACAGAGGCGGAAACCAGTACCTCCGACATGAAGATGAACAAGCTCTTCTG
GATCAGAATTCTCAAACTCCTCCTCCAAGCCCTTTCTCAGTGCAAGCTTTTAATAAAGGGGCAAGTTGCAGTGCCCAAGGATTTGATTAT
GGACTCGGAAATAGCAAAGGTGATCGAGGAAACATCTCAACATCTTCTAAACCAGCCTCTACATCAGGAAAATCAGAGCTGTCCTCTAAA
CACAGCAGATCGCTTAAACCTGATGGACGTATGAGCCGGACTACTGCTGATCAGAAGAAGCCAAGGGGCACAGAAAGTTTATCTGCTAGT
GAATCCCTCATCTTAAAATCTGATGCTGCAAAGTTGAGGTCAGATTCCCACAGTAGGTCATTATCCCCCAACCATAACACCTTGCAGACA
TTGAAATCTGATGGGAGGATGCCTTCTAGCTCCAGAGCTGAATCCCCAGGACCAGGTTCTCGGTTGTCATCTCCTAAGCCAAAGACTCTC
CCAGCCAATAGGTCTAGCCCATCGGGTGCTAGTTCTCCACGCTCCTCCTCACCACATGATAAAAATCTACCTCAAAAAAGTACTGCTCCT
GTTAAGACAAAGCTTGATCCTCCTCGGGAACGTTCTAAATCAGACTCTTACACACTTGATCCAGATACCCTCCGCAAGAAGAAAATGCCC
CTCACAGAACCTTTGAGAGGACGGTCAACGTCACCAAAACCAAAATCAGTACCAAAGGATTCTACAGATTCCCCTGGATCTGAAAATAGA
GCTCCCTCTCCCCATGTGGTACAGGAAAACCTCCACAGTGAGGTGGTCGAAGTCTGCACCTCAAGTACTTTAAAAACAAATAGTCTAACA
GACAGCACCTGCGATGACAGCAGTGAATTTAAGAGTGTGGATGAAGGTTCAAATAAAGTTCATTTTAGCATTGGAAAAGCACCACTGAAA
GATGAACAGGAAATGAGAGCATCTCCCAAAATAAGTCGAAAATGTGCTAATAGACACACCAGGCCCAAAAAAGAAAAATCGAGTTTTCTT
TTCAAAGGAGATGGATCCAAGCCTTTAGAGCCAGCCAAGCAAGCCATGTCTCCTTCTGTGGCCGAATGTGCCAGAGCTGTGTTTGCTTCC
TTCCTCTGGCATGAAGGCATAGTACATGATGCAATGGCTTGTTCTTCTTTCCTAAAGTTTCATCCTGAACTTTCCAAAGAACATGCTCCT
ATAAGGAGTAGTTTAAATAGCCAACAACCTACAGAGGAAAAAGAAACCAAGTTAAAAAATAGACATTCATTAGAAATATCATCTGCACTG
AATATGTTTAATATTGCACCCCATGGACCAGATATATCTAAGATGGGTAGCATCAACAAAAACAAGGTATTGTCTATGCTTAAGGAACCA
CCTCTGCATGAAAAATGTGAGGATGGGAAAACCGAGACCACTTTTGAAATGTCCATGCATAACACAATGAAGTCTAAGTCTCCTCTTCCC
TTAACTTTACAACATTTAGTGGCTTTTTGGGAAGACATCTCTTTGGCTACTATCAAAGCTGCTTCCCAGAATATGATTTTTCCAAGTCCT
GGTTCCTGTGCAGTTCTTAAAAAGAAAGAGTGTGAGAAAGAGAATAAGAAGTCCAAAAAGGAAAAAAAGAAAAAAGAAAAGGCAGAAGTT
AGGCCCAGGGGTAATTTGTTTGGAGAGATGGCCCAGCTGGCAGTAGGAGGACCAGAGAAAGATACCATCTGTGAACTGTGTGGGGAGTCA
CATCCATACCCGGTGACCTATCACATGAGACAAGCTCACCCAGGTTGTGGCCGATATGCTGGTGGACAAGGTTACAATAGCATTGGGCAT
TTTTGTGGAGGATGGGCTGGTAACTGTGGTGATGGTGGCATAGGAGGAAGCACTTGGTATCTGGTATGTGATCGCTGTAGAGAAAAATAC
CTCCGCGAAAAACAGGCTGCTGCAAGGGAGAAGGTCAAACAATCTAGGAGAAAACCAATGCAAGTCAAGACCCCTCGTGCCTTGCCCACC
ATGGAAGCTCACCAGGTGATTAAAGCCAATGCACTCTTCCTGCTGTCCCTGAGCAGTGCAGCAGAACCGAGCATTCTGTGTTACCATCCT
GCAAAGCCATTCCAATCTCAGTTGCCCAGTGTAAAAGAAGGCATTTCTGAGGATCTTCCTGTGAAAATGCCTTGTCTCTACCTGCAGACA
TTAGCTAGGCATCATCATGAAAATTTTGTGGGCTATCAAGATGACAATCTATTCCAGGATGAAATGAGATATCTACGTTCAACATCTGTA
CCTGCCCCGTATATATCAGTAACTCCTGATGCAAGTCCTAATGTATTTGAAGAGCCAGAGAGCAATATGAAGTCTATGCCACCAAGTTTA
GAAACCAGTCCCATAACTGATACTGATCTTGCAAAGAGAACTGTCTTCCAAAGATCATACTCAGTTGTTGCTTCCGAATATGATAAACAA
CACTCCATTTTACCTGCACGAGTTAAAGCTATTCCTAGAAGAAGAGTTAACAGTGGAGACACTGAAGTTGGTTCTTCCCTTTTGAGACAT
CCGTCTCCTGAGCTTTCTCGGCTAATCTCAGCCCACAGCTCTCTTTCTAAAGGAGAACGAAATTTCCAGTGGCCAGTTTTAGCTTTTGTT
ATACAACATCATGATCTAGAAGGTCTTGAAATAGCAATGAAACAGGCCCTAAGGAAATCTGCTTGTCGAGTTTTTGCTATGGAGGCTTTC
AACTGGCTTCTGTGTAATGTCATCCAAACCACTTCTCTCCATGATATTCTGTGGCATTTTGTGGCATCACTGACTCCTGCACCAGTGGAA
CCAGAGGAAGAAGAGGATGAAGAAAATAAAACAAGCAAAGAAAATTCAGAACAATTTATGTTATGATAGCAATTTTCTGCATAGCATCAG
CAATGAGTCTGTACAACTGTCTTGCTGCACTAATTCATAAGATACCATATGGACAATGCACGATTGCATGTCGTGGCAAAAACATGGAAG
TGAGACTTATTTTTCTCTCTGGACTGTGCATAGCAGTAGCTGTTGTTTGGGCTGTGTTTCGAAATGAAGACAGGTGGGCTTGGATTTTAC
AGGATATCTTGGGGATTGCTTTCTGTCTGAATTTAATTAAAACACTGAAGTTGCCCAACTTCAAGTCATGTGTGATACTTCTAGGCCTTC
TCCTCCTCTATGATGTATTTTTTGTTTTCATAACACCATTCATCACAAAGAATGGTGAGAGTATCATGGTTGAACTCGCAGCTGGACCTT
TTGGAAATAATGAAAAGTTGCCAGTAGTCATCAGAGTACCAAAACTGATCTATTTCTCAGTAATGAGTGTGTGCCTCATGCCTGTTTCAA
TATTGGGTTTTGGAGACATTATTGTACCAGGCCTGTTGATTGCATACTGTAGAAGATTTGATGTTCAGACTGGTTCTTCTTACATATACT
ATGTTTCGTCTACAGTTGCCTATGCTATTGGCATGATACTTACATTTGTTGTTCTGGTGCTGATGAAAAAGGGGCAACCTGCTCTCCTCT
ATTTAGTACCTTGCACACTTATTACTGCCTCAGTTGTTGCCTGGAGACGTAAGGAAATGAAAAAGTTCTGGAAAGGTAACAGCTATCAGA
TGATGGACCATTTGGATTGTGCAACAAATGAAGAAAACCCTGTGATATCTGGTGAACAGATTGTCCAGCAATAATATTATGTGGAACTGC
TATAATGTGTCATTGATTTTCTACAAATAGACTTCGACTTTTTAAATTGACTTTTGAATTGACAATCTGAAAGAGTCTTCAATGATATGC
TTGCAAAAATATATTTTTATGAGCTGGTACTGACAGTTACATCATAAATAACTAAAACGCTTTGCTTTTAATGTTAAAGTTGTGCCTTCA
CATTAAATAAAACATATGGTCTGTGTAGTTTCCGAGATGTACTATATACAGTATATTTTTCTAAAAAAAAATGCCTTGACCCACCCCTAT
ACTTTTTTTTAACGAAATCTGTTTCTTTCAGCTCTGATGGTAGATACAAGTAGTTACTATTTCTGAATGGGTTTTACTGTAAAGAATTAT
GCAAATTGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCGGGCGGATCACGAGGTCAGGAGATCGAGAC


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FusionGenePPI for MYCBP2_SPPL2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYCBP2BAK1, SFN, MYC, USP11, RAE1, WDR48, NR1D1, UBC, UBE3A, YWHAB, YWHAG, CALM1, SIRT7, FBXO45, CUL4B, ATP13A2, YWHAQ, NOS2, CBX2, CBX4, ROBO2, HDAC11, LGR4, CCDC8, CCDC158, TDGF1, SESN3, DEF6, SKAP1, CLEC11A, CASQ2, LILRA3, ALDH1L2, WHSC1, PLK4, MED4, SRPK2, LGALS3BP, YWHAH, YWHAZ, SLAIN2, VPS26B, SKA1, HEY1, CRY1, CRY2, FBXW7, MEX3C, FAF1, ATOH1, CDC14A, STAT2, DOCK5, CETN1, TXNIP, CDH19, CCDC65, GUCY1B3, GDF10, PAPL, MYLIP, PGBD1, PDGFB, CTNNA3, PCDHA3, NEURL4SPPL2ASGTA, NFKB1, LGALS8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYCBP2_SPPL2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYCBP2_SPPL2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource