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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22941

FusionGeneSummary for MYBL2_MYBL2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYBL2_MYBL2
Fusion gene ID: 22941
HgeneTgene
Gene symbol

MYBL2

MYBL2

Gene ID

4605

4605

Gene nameMYB proto-oncogene like 2MYB proto-oncogene like 2
SynonymsB-MYB|BMYBB-MYB|BMYB
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionmyb-related protein Bmyb-like protein 2v-myb avian myeloblastosis viral oncogene homolog-like 2v-myb myeloblastosis viral oncogene homolog-like 2myb-related protein Bmyb-like protein 2v-myb avian myeloblastosis viral oncogene homolog-like 2v-myb myeloblastosis viral oncogene homolog-like 2
Modification date2018052320180523
UniProtAcc

P10244

P10244

Ensembl transtripts involved in fusion geneENST00000396863, ENST00000217026, 
ENST00000396863, ENST00000217026, 
Fusion gene scores* DoF score3 X 4 X 3=364 X 5 X 3=60
# samples 68
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYBL2 [Title/Abstract] AND MYBL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYBL2

GO:0045944

positive regulation of transcription by RNA polymerase II

10770937

TgeneMYBL2

GO:0045944

positive regulation of transcription by RNA polymerase II

10770937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE264691MYBL2chr20

42331135

-MYBL2chr20

42331220

+
ChiTaRS3.1BE252428MYBL2chr20

42341680

-MYBL2chr20

42343783

+
ChiTaRS3.1AW246196MYBL2chr20

42331135

-MYBL2chr20

42331220

+
ChiTaRS3.1BE264624MYBL2chr20

42331135

-MYBL2chr20

42331220

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000396863ENST00000396863MYBL2chr20

42331135

-MYBL2chr20

42331220

+
intron-3CDSENST00000396863ENST00000217026MYBL2chr20

42331135

-MYBL2chr20

42331220

+
intron-3CDSENST00000217026ENST00000396863MYBL2chr20

42331135

-MYBL2chr20

42331220

+
intron-3CDSENST00000217026ENST00000217026MYBL2chr20

42331135

-MYBL2chr20

42331220

+
In-frameENST00000396863ENST00000396863MYBL2chr20

42341680

-MYBL2chr20

42343783

+
In-frameENST00000396863ENST00000217026MYBL2chr20

42341680

-MYBL2chr20

42343783

+
In-frameENST00000217026ENST00000396863MYBL2chr20

42341680

-MYBL2chr20

42343783

+
In-frameENST00000217026ENST00000217026MYBL2chr20

42341680

-MYBL2chr20

42343783

+

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FusionProtFeatures for MYBL2_MYBL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYBL2

P10244

MYBL2

P10244

Transcription factor involved in the regulation of cellsurvival, proliferation, and differentiation. Transactivates theexpression of the CLU gene. {ECO:0000269|PubMed:10770937}. Transcription factor involved in the regulation of cellsurvival, proliferation, and differentiation. Transactivates theexpression of the CLU gene. {ECO:0000269|PubMed:10770937}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYBL2_MYBL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYBL2_MYBL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYBL2_MYBL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYBL2_MYBL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource