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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22940

FusionGeneSummary for MYBL2_IFT52

check button Fusion gene summary
Fusion gene informationFusion gene name: MYBL2_IFT52
Fusion gene ID: 22940
HgeneTgene
Gene symbol

MYBL2

IFT52

Gene ID

4605

51098

Gene nameMYB proto-oncogene like 2intraflagellar transport 52
SynonymsB-MYB|BMYBC20orf9|CGI-53|NGD2|NGD5
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionmyb-related protein Bmyb-like protein 2v-myb avian myeloblastosis viral oncogene homolog-like 2v-myb myeloblastosis viral oncogene homolog-like 2intraflagellar transport protein 52 homologprotein NGD5 homolog
Modification date2018052320180523
UniProtAcc

P10244

Q9Y366

Ensembl transtripts involved in fusion geneENST00000396863, ENST00000217026, 
ENST00000373030, ENST00000373039, 
ENST00000471199, 
Fusion gene scores* DoF score3 X 4 X 3=367 X 7 X 6=294
# samples 67
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYBL2 [Title/Abstract] AND IFT52 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYBL2

GO:0045944

positive regulation of transcription by RNA polymerase II

10770937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-CC-A3MC-01AMYBL2chr20

42320959

+IFT52chr20

42249497

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000396863ENST00000373030MYBL2chr20

42320959

+IFT52chr20

42249497

+
In-frameENST00000396863ENST00000373039MYBL2chr20

42320959

+IFT52chr20

42249497

+
5CDS-intronENST00000396863ENST00000471199MYBL2chr20

42320959

+IFT52chr20

42249497

+
In-frameENST00000217026ENST00000373030MYBL2chr20

42320959

+IFT52chr20

42249497

+
In-frameENST00000217026ENST00000373039MYBL2chr20

42320959

+IFT52chr20

42249497

+
5CDS-intronENST00000217026ENST00000471199MYBL2chr20

42320959

+IFT52chr20

42249497

+

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FusionProtFeatures for MYBL2_IFT52


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYBL2

P10244

IFT52

Q9Y366

Transcription factor involved in the regulation of cellsurvival, proliferation, and differentiation. Transactivates theexpression of the CLU gene. {ECO:0000269|PubMed:10770937}. Involved in ciliogenesis as part of a complex involvedin intraflagellar transport (IFT), the bi-directional movement ofparticles required for the assembly, maintenance and functioningof primary cilia (PubMed:27466190). Required for the anterogradetransport of IFT88 (PubMed:27466190).{ECO:0000269|PubMed:27466190}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYBL2chr20:42320959chr20:42249497ENST00000217026+614106_129221701DNA bindingH-T-H motif
HgeneMYBL2chr20:42320959chr20:42249497ENST00000217026+614157_180221701DNA bindingH-T-H motif
HgeneMYBL2chr20:42320959chr20:42249497ENST00000217026+61454_77221701DNA bindingH-T-H motif
HgeneMYBL2chr20:42320959chr20:42249497ENST00000217026+614134_184221701DomainHTH myb-type 3
HgeneMYBL2chr20:42320959chr20:42249497ENST00000217026+61426_77221701DomainHTH myb-type 1
HgeneMYBL2chr20:42320959chr20:42249497ENST00000217026+61478_133221701DomainHTH myb-type 2
TgeneIFT52chr20:42320959chr20:42249497ENST00000373030+714348_351233438Compositional biasNote=Poly-Pro
TgeneIFT52chr20:42320959chr20:42249497ENST00000373039+714348_351233438Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYBL2chr20:42320959chr20:42249497ENST00000217026+614411_417221701MotifNuclear localization signal
HgeneMYBL2chr20:42320959chr20:42249497ENST00000217026+614564_584221701MotifNote=Bipartite nuclear localization signal


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FusionGeneSequence for MYBL2_IFT52


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYBL2_IFT52


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MYBL2ZNF622, CDKN1C, RBL1, E2F1, E2F3, EP300, CREBBP, PARP1, CDK2, CCNA1, MYBL2, CDK9, CCNT1, SKP2, LZTR1, TRIM15, ZBTB9, NLK, HIPK2, LIN54, LIN9, LIN37, LIN52, MAPK6, MAP1LC3B, RBBP4, FLNA, SPTA1, CLTC, SPTBN1, CLTA, CCNE1, CXCR4, UBE2D4, TTF2, EWSR1, CTDSPL2, NUF2, PPP2R3C, ZSCAN26, TEAD2, CCNF, FOXM1, PLA2G4A, EPAS1IFT52ANKRD55, IFT57, ARL13B, IFT80, UBXN10, SBF1, TTC30A, TTC30B, FGF8, IFT74, LRRC27, PTPN21, IFT46, HSPB11, TTC26, IFT22, IFT88, IFT81, SLC35E1, FAM210A, IFT172, IFT27, IFT20, MAPRE1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYBL2_IFT52


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYBL2_IFT52


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource