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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22933

FusionGeneSummary for MYADM_SPIDR

check button Fusion gene summary
Fusion gene informationFusion gene name: MYADM_SPIDR
Fusion gene ID: 22933
HgeneTgene
Gene symbol

MYADM

SPIDR

Gene ID

91663

23514

Gene namemyeloid associated differentiation markerscaffold protein involved in DNA repair
SynonymsSB135KIAA0146
Cytomap

19q13.42

8q11.21

Type of geneprotein-codingprotein-coding
Descriptionmyeloid-associated differentiation markermyeloid upregulated proteinDNA repair-scaffolding proteinscaffolding protein involved in DNA repair
Modification date2018051920180523
UniProtAcc

Q96S97

Q14159

Ensembl transtripts involved in fusion geneENST00000336967, ENST00000391771, 
ENST00000391770, ENST00000391769, 
ENST00000391768, 		ENST00000297423, 
ENST00000518074, ENST00000541342, 
ENST00000521214, ENST00000517693, 
ENST00000518060, 
Fusion gene scores* DoF score1 X 2 X 1=212 X 13 X 8=1248
# samples 218
** MAII scorelog2(2/2*10)=3.32192809488736log2(18/1248*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYADM [Title/Abstract] AND SPIDR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYADM

GO:0034115

negative regulation of heterotypic cell-cell adhesion

23264465

TgeneSPIDR

GO:0006974

cellular response to DNA damage stimulus

23509288

TgeneSPIDR

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

TgeneSPIDR

GO:0031334

positive regulation of protein complex assembly

23509288

TgeneSPIDR

GO:0070202

regulation of establishment of protein localization to chromosome

23509288

TgeneSPIDR

GO:0071479

cellular response to ionizing radiation

23509288|23754376

TgeneSPIDR

GO:0072711

cellular response to hydroxyurea

23509288

TgeneSPIDR

GO:0072757

cellular response to camptothecin

23509288


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI021868MYADMchr19

54377456

+SPIDRchr8

48511721

-
ChiTaRS3.1BI024730MYADMchr19

54377459

+SPIDRchr8

48511721

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000336967ENST00000297423MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000336967ENST00000518074MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000336967ENST00000541342MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000336967ENST00000521214MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000336967ENST00000517693MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000336967ENST00000518060MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391771ENST00000297423MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391771ENST00000518074MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391771ENST00000541342MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000391771ENST00000521214MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000391771ENST00000517693MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000391771ENST00000518060MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391770ENST00000297423MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391770ENST00000518074MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391770ENST00000541342MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000391770ENST00000521214MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000391770ENST00000517693MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000391770ENST00000518060MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391769ENST00000297423MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391769ENST00000518074MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391769ENST00000541342MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000391769ENST00000521214MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000391769ENST00000517693MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000391769ENST00000518060MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391768ENST00000297423MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391768ENST00000518074MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000391768ENST00000541342MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000391768ENST00000521214MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000391768ENST00000517693MYADMchr19

54377456

+SPIDRchr8

48511721

-
5CDS-intronENST00000391768ENST00000518060MYADMchr19

54377456

+SPIDRchr8

48511721

-
Frame-shiftENST00000336967ENST00000297423MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000336967ENST00000518074MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000336967ENST00000541342MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000336967ENST00000521214MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000336967ENST00000517693MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000336967ENST00000518060MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391771ENST00000297423MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391771ENST00000518074MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391771ENST00000541342MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000391771ENST00000521214MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000391771ENST00000517693MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000391771ENST00000518060MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391770ENST00000297423MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391770ENST00000518074MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391770ENST00000541342MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000391770ENST00000521214MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000391770ENST00000517693MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000391770ENST00000518060MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391769ENST00000297423MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391769ENST00000518074MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391769ENST00000541342MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000391769ENST00000521214MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000391769ENST00000517693MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000391769ENST00000518060MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391768ENST00000297423MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391768ENST00000518074MYADMchr19

54377459

+SPIDRchr8

48511721

-
Frame-shiftENST00000391768ENST00000541342MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-3UTRENST00000391768ENST00000521214MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000391768ENST00000517693MYADMchr19

54377459

+SPIDRchr8

48511721

-
5CDS-intronENST00000391768ENST00000518060MYADMchr19

54377459

+SPIDRchr8

48511721

-

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FusionProtFeatures for MYADM_SPIDR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYADM

Q96S97

SPIDR

Q14159

Plays a role in DNA double-strand break (DBS) repair viahomologous recombination (HR). Serves as a scaffolding proteinthat helps to promote the recruitment of DNA-processing enzymeslike the helicase BLM and recombinase RAD51 to site of DNA damage,and hence contributes to maintain genomic integrity.{ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MYADM_SPIDR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MYADM_SPIDR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MYADM_SPIDR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYADM_SPIDR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYADMC0023893Liver Cirrhosis, Experimental1CTD_human